FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123801874> ?p ?o ?g. }

• W2123801874 endingPage "596" @default.
• W2123801874 startingPage "588" @default.
• W2123801874 abstract "BACKGROUND: Matrix metalloproteinase-9 (MMP-9 or gelatinase B) has recently been implicated in the IL-8-induced mobilization of HPCs in rhesus monkeys and mice. It is not known whether administration of G−CSF causes expression of MMP-9 during HPC mobilization. STUDY DESIGN AND METHODS: Blood samples from 15 allogeneic progenitor cell donors were collected before and during G−CSF-induced HPC mobilization. The expression of the gelatinases MMP-2 and MMP-9 in the plasma of the donors was analyzed by ELISA and zymographic analysis. Gelatinolytic activity was measured with a fluorometric assay that was specific for gelatinases. Expression of IL-6, IL-8, and soluble vascular cell adhesion molecule (VCAM) was measured by ELISA. RESULTS: Highly elevated latent gelatinolytic activity was found on Days 4 and 5 of G−CSF treatment in comparison to pretreatment activity. ELISA and zymographic analyses revealed pro-MMP-9 as the major source of the latent gelatinolytic plasma activity during mobilization. Pro-MMP-2 was not elevated compared with pretreatment levels. As IL-8 has been implicated in the expression of MMP-9, IL-8 concentrations were measured in plasma samples from donors and patients immediately before the start of HPC apheresis, but no significantly elevated IL-8 concentrations were noted. In contrast, pro-MMP-9 and latent gelatinolytic activity was highly correlated with IL-6, which was strongly elevated during mobilization therapy. Finally, soluble VCAM was equally significantly elevated on the days of apheresis. CONCLUSIONS: G−CSF mobilization treatment induces MMP-9, IL-6, and soluble VCAM. Expression of MMP-9 might be involved in the mobilization of human HPCs and might be a final common pathway of different mobilization therapies. Our data do not support a role of IL-8 in G−CSF-induced mobilization. In contrast, IL-6 might be involved in the G−CSF-induced expression of MMP-9." @default.
• W2123801874 created "2016-06-24" @default.
• W2123801874 creator A5002022076 @default.
• W2123801874 creator A5021890288 @default.
• W2123801874 creator A5043761531 @default.
• W2123801874 creator A5084042593 @default.
• W2123801874 creator A5090803784 @default.
• W2123801874 date "2002-05-01" @default.
• W2123801874 modified "2023-10-01" @default.
• W2123801874 title "Matrix metalloproteinase-9 (gelatinase B) is elevated during mobilization of peripheral blood progenitor cells by G-CSF" @default.
• W2123801874 cites W120762819 @default.
• W2123801874 cites W1216511763 @default.
• W2123801874 cites W1224806054 @default.
• W2123801874 cites W1490135869 @default.
• W2123801874 cites W1546619202 @default.
• W2123801874 cites W1547715367 @default.
• W2123801874 cites W1562667342 @default.
• W2123801874 cites W1583052663 @default.
• W2123801874 cites W1786249782 @default.
• W2123801874 cites W1972843541 @default.
• W2123801874 cites W1984595136 @default.
• W2123801874 cites W2042813728 @default.
• W2123801874 cites W2061285112 @default.
• W2123801874 cites W2062784484 @default.
• W2123801874 cites W2070816681 @default.
• W2123801874 cites W2071660979 @default.
• W2123801874 cites W2071683870 @default.
• W2123801874 cites W2075262827 @default.
• W2123801874 cites W2084032150 @default.
• W2123801874 cites W2095498651 @default.
• W2123801874 cites W2098076093 @default.
• W2123801874 cites W2101163518 @default.
• W2123801874 cites W2138917119 @default.
• W2123801874 cites W2145906274 @default.
• W2123801874 cites W2148673523 @default.
• W2123801874 cites W2155388864 @default.
• W2123801874 cites W2157145995 @default.
• W2123801874 cites W2158008521 @default.
• W2123801874 cites W2171663131 @default.
• W2123801874 cites W2262250683 @default.
• W2123801874 cites W2275724390 @default.
• W2123801874 cites W2313178299 @default.
• W2123801874 cites W2413041165 @default.
• W2123801874 cites W272884299 @default.
• W2123801874 cites W4243294724 @default.
• W2123801874 cites W77344512 @default.
• W2123801874 doi "https://doi.org/10.1046/j.1537-2995.2002.00088.x" @default.
• W2123801874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12084167" @default.
• W2123801874 hasPublicationYear "2002" @default.
• W2123801874 type Work @default.
• W2123801874 sameAs 2123801874 @default.
• W2123801874 citedByCount "33" @default.
• W2123801874 countsByYear W21238018742012 @default.
• W2123801874 countsByYear W21238018742013 @default.
• W2123801874 countsByYear W21238018742014 @default.
• W2123801874 countsByYear W21238018742016 @default.
• W2123801874 crossrefType "journal-article" @default.
• W2123801874 hasAuthorship W2123801874A5002022076 @default.
• W2123801874 hasAuthorship W2123801874A5021890288 @default.
• W2123801874 hasAuthorship W2123801874A5043761531 @default.
• W2123801874 hasAuthorship W2123801874A5084042593 @default.
• W2123801874 hasAuthorship W2123801874A5090803784 @default.
• W2123801874 hasConcept C109523444 @default.
• W2123801874 hasConcept C126322002 @default.
• W2123801874 hasConcept C134018914 @default.
• W2123801874 hasConcept C156708679 @default.
• W2123801874 hasConcept C166957645 @default.
• W2123801874 hasConcept C185592680 @default.
• W2123801874 hasConcept C201750760 @default.
• W2123801874 hasConcept C203014093 @default.
• W2123801874 hasConcept C2776223131 @default.
• W2123801874 hasConcept C2776232661 @default.
• W2123801874 hasConcept C2776738589 @default.
• W2123801874 hasConcept C28328180 @default.
• W2123801874 hasConcept C2910246616 @default.
• W2123801874 hasConcept C71924100 @default.
• W2123801874 hasConcept C86803240 @default.
• W2123801874 hasConcept C89560881 @default.
• W2123801874 hasConcept C95444343 @default.
• W2123801874 hasConcept C95457728 @default.
• W2123801874 hasConceptScore W2123801874C109523444 @default.
• W2123801874 hasConceptScore W2123801874C126322002 @default.
• W2123801874 hasConceptScore W2123801874C134018914 @default.
• W2123801874 hasConceptScore W2123801874C156708679 @default.
• W2123801874 hasConceptScore W2123801874C166957645 @default.
• W2123801874 hasConceptScore W2123801874C185592680 @default.
• W2123801874 hasConceptScore W2123801874C201750760 @default.
• W2123801874 hasConceptScore W2123801874C203014093 @default.
• W2123801874 hasConceptScore W2123801874C2776223131 @default.
• W2123801874 hasConceptScore W2123801874C2776232661 @default.
• W2123801874 hasConceptScore W2123801874C2776738589 @default.
• W2123801874 hasConceptScore W2123801874C28328180 @default.
• W2123801874 hasConceptScore W2123801874C2910246616 @default.
• W2123801874 hasConceptScore W2123801874C71924100 @default.
• W2123801874 hasConceptScore W2123801874C86803240 @default.
• W2123801874 hasConceptScore W2123801874C89560881 @default.
• W2123801874 hasConceptScore W2123801874C95444343 @default.
• W2123801874 hasConceptScore W2123801874C95457728 @default.

• next