FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123804433> ?p ?o ?g. }

• W2123804433 endingPage "4187" @default.
• W2123804433 startingPage "4173" @default.
• W2123804433 abstract "JunB, a member of the AP-1 family of dimeric transcription factors, is best known as a cell proliferation inhibitor, a senescence inducer, and a tumor suppressor, although it also has been attributed a cell division-promoting activity. Its effects on the cell cycle have been studied mostly in G1 and S phases, whereas its role in G2 and M phases still is elusive. Using cell synchronization experiments, we show that JunB levels, which are high in S phase, drop during mid- to late G2 phase due to accelerated phosphorylation-dependent degradation by the proteasome. The forced expression of an ectopic JunB protein in late G2 phase indicates that JunB decay is necessary for the subsequent reduction of cyclin A2 levels in prometaphase, the latter event being essential for proper mitosis. Consistently, abnormal JunB expression in late G2 phase entails a variety of mitotic defects. As these aberrations may cause genetic instability, our findings contrast with the acknowledged tumor suppressor activity of JunB and reveal a mechanism by which the deregulation of JunB might contribute to tumorigenesis." @default.
• W2123804433 created "2016-06-24" @default.
• W2123804433 creator A5005339371 @default.
• W2123804433 creator A5030170326 @default.
• W2123804433 creator A5037383252 @default.
• W2123804433 creator A5044263313 @default.
• W2123804433 creator A5057509693 @default.
• W2123804433 creator A5058363334 @default.
• W2123804433 creator A5086975017 @default.
• W2123804433 date "2008-06-01" @default.
• W2123804433 modified "2023-10-17" @default.
• W2123804433 title "JunB Breakdown in Mid-/Late G₂ Is Required for Down-Regulation of Cyclin A2 Levels and Proper Mitosis" @default.
• W2123804433 cites W1483395792 @default.
• W2123804433 cites W1506555948 @default.
• W2123804433 cites W1865272626 @default.
• W2123804433 cites W1963967499 @default.
• W2123804433 cites W1975826991 @default.
• W2123804433 cites W1977622673 @default.
• W2123804433 cites W1979524759 @default.
• W2123804433 cites W1986148855 @default.
• W2123804433 cites W1991326902 @default.
• W2123804433 cites W1991927407 @default.
• W2123804433 cites W1992772703 @default.
• W2123804433 cites W1992970966 @default.
• W2123804433 cites W1994219871 @default.
• W2123804433 cites W2005635949 @default.
• W2123804433 cites W2009297613 @default.
• W2123804433 cites W2009548698 @default.
• W2123804433 cites W2009781189 @default.
• W2123804433 cites W2009946316 @default.
• W2123804433 cites W2013216643 @default.
• W2123804433 cites W2016182138 @default.
• W2123804433 cites W2018210785 @default.
• W2123804433 cites W2023572101 @default.
• W2123804433 cites W2029875848 @default.
• W2123804433 cites W2029882556 @default.
• W2123804433 cites W2034310924 @default.
• W2123804433 cites W2036826205 @default.
• W2123804433 cites W2039832564 @default.
• W2123804433 cites W2041665428 @default.
• W2123804433 cites W2048109276 @default.
• W2123804433 cites W2061096783 @default.
• W2123804433 cites W2067427748 @default.
• W2123804433 cites W2069691728 @default.
• W2123804433 cites W2072319964 @default.
• W2123804433 cites W2085807801 @default.
• W2123804433 cites W2087592728 @default.
• W2123804433 cites W2089975983 @default.
• W2123804433 cites W2092762008 @default.
• W2123804433 cites W2097281602 @default.
• W2123804433 cites W2104458086 @default.
• W2123804433 cites W2111919654 @default.
• W2123804433 cites W2122742344 @default.
• W2123804433 cites W2134406847 @default.
• W2123804433 cites W2134622777 @default.
• W2123804433 cites W2138779676 @default.
• W2123804433 cites W2139964260 @default.
• W2123804433 cites W2141028968 @default.
• W2123804433 cites W2146234147 @default.
• W2123804433 cites W2150560269 @default.
• W2123804433 cites W2154557203 @default.
• W2123804433 cites W2157528884 @default.
• W2123804433 cites W2158965355 @default.
• W2123804433 cites W2161579926 @default.
• W2123804433 cites W2162167880 @default.
• W2123804433 cites W2322523258 @default.
• W2123804433 cites W2329404090 @default.
• W2123804433 cites W2335761521 @default.
• W2123804433 doi "https://doi.org/10.1128/mcb.01620-07" @default.
• W2123804433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423125" @default.
• W2123804433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18391017" @default.
• W2123804433 hasPublicationYear "2008" @default.
• W2123804433 type Work @default.
• W2123804433 sameAs 2123804433 @default.
• W2123804433 citedByCount "23" @default.
• W2123804433 countsByYear W21238044332012 @default.
• W2123804433 countsByYear W21238044332013 @default.
• W2123804433 countsByYear W21238044332014 @default.
• W2123804433 countsByYear W21238044332015 @default.
• W2123804433 countsByYear W21238044332016 @default.
• W2123804433 countsByYear W21238044332021 @default.
• W2123804433 countsByYear W21238044332022 @default.
• W2123804433 countsByYear W21238044332023 @default.
• W2123804433 crossrefType "journal-article" @default.
• W2123804433 hasAuthorship W2123804433A5005339371 @default.
• W2123804433 hasAuthorship W2123804433A5030170326 @default.
• W2123804433 hasAuthorship W2123804433A5037383252 @default.
• W2123804433 hasAuthorship W2123804433A5044263313 @default.
• W2123804433 hasAuthorship W2123804433A5057509693 @default.
• W2123804433 hasAuthorship W2123804433A5058363334 @default.
• W2123804433 hasAuthorship W2123804433A5086975017 @default.
• W2123804433 hasBestOaLocation W21238044331 @default.
• W2123804433 hasConcept C104317684 @default.
• W2123804433 hasConcept C120089663 @default.
• W2123804433 hasConcept C1491633281 @default.
• W2123804433 hasConcept C153911025 @default.
• W2123804433 hasConcept C154202817 @default.
• W2123804433 hasConcept C2781085546 @default.

• next