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• W2123807140 abstract "BackgroundPeripheral T-cell lymphoma unspecified (PTCLU) and mycosis fungoides (MF) often show resistance to conventional chemotherapy. Gemcitabine should be considered a suitable option. We report the long-term update of 39 pretreated T-cell lymphoma patients treated with gemcitabine.Patients and methodsFrom May 1997 to September 2007, 39 pretreated MF and PTCLU patients received gemcitabine. Inclusion criteria were as follows: histologic diagnosis of MF or PTCLU; relapsed/refractory disease; age ≥18 years; and World Health Organization performance status of two or less. Nineteen patients had MF and 20 PTCLU. All patients with MF had a T3–T4, N0, and M0 disease and patients with PTCLU had stage III–IV disease. Gemcitabine was given on days 1, 8, and 15 on a 28-day schedule (1200 mg/m2/day) for a total of three to six cycles.ResultsOverall response rate was 51% (20 of 39 patients); complete response (CR) and partial response (PR) rates were 23% (9 of 39 patients) and 28% (11 of 39 patients), respectively. Patients with MF had a CR rate of 16% and a PR rate of 32% compared with a CR rate of 30% and a PR rate of 25% of PTCLU patients. Among the CR patients, 7 of 9 are in continuous complete response with a variable disease-free interval (15–120 months).ConclusionIn our experience, gemcitabine proved to be effective in pretreated MF and PTCLU patients, even in the long term." @default.
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• W2123807140 date "2010-04-01" @default.
• W2123807140 modified "2023-10-16" @default.
• W2123807140 title "Gemcitabine as single agent in pretreated T-cell lymphoma patients: evaluation of the long-term outcome" @default.
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• W2123807140 doi "https://doi.org/10.1093/annonc/mdp508" @default.
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