FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123811191> ?p ?o ?g. }

• W2123811191 endingPage "1166" @default.
• W2123811191 startingPage "1166" @default.
• W2123811191 abstract "<h3>Context</h3> The benzodiazepine (BZD) receptor system has been implicated in the pathophysiologic mechanism of panic disorder (PD) by indirect evidence from pharmacological challenge studies and by direct evidence from single-photon emission computed tomography and positron emission tomography neuroimaging studies. However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects. <h3>Objective</h3> To compare BZD receptor binding between subjects with PD and healthy control subjects. <h3>Design</h3> Cross-sectional study for association. <h3>Setting</h3> Psychiatric outpatient clinic of the National Institute of Mental Health. <h3>Participants</h3> Fifteen subjects with PD who were naïve to BZD drug exposure and were not receiving other drug treatment, and 18 healthy controls. <h3>Intervention</h3> Images of BZD receptor binding were acquired using positron emission tomography and flumazenil tagged with carbon 11. <h3>Main Outcome Measures</h3> The BZD receptor binding potential was assessed by a simplified reference tissue-tracer kinetic model. <h3>Results</h3> The BZD receptor binding potential was decreased in multiple areas of the frontal, temporal, and parietal cortices and was increased in the hippocampus/parahippocampal region in subjects with PD vs controls. The most significant decrease was located in the dorsal anterolateral prefrontal cortex (DALPFC); the most significant increase, in the hippocampus/parahippocampal gyrus. These abnormalities were not accounted for by comorbid depression. In subjects with PD, the severity of panic and anxiety symptoms correlated positively with BZD receptor binding in the DALPFC but negatively with binding in the hippocampus/parahippocampal gyrus. <h3>Conclusions</h3> These data provide evidence of abnormal BZD–γ-aminobutyric acid type A receptor binding in PD, suggesting that basal and/or compensatory changes in inhibitory neurotransmission play roles in the pathophysiologic mechanism of PD. They also provide evidence of an impairment of frontal-limbic interaction in the modulation of anxiety responses, consistent with previous functional and structural neuroimaging studies in PD." @default.
• W2123811191 created "2016-06-24" @default.
• W2123811191 creator A5012357230 @default.
• W2123811191 creator A5029257842 @default.
• W2123811191 creator A5043955268 @default.
• W2123811191 creator A5045276496 @default.
• W2123811191 creator A5065976774 @default.
• W2123811191 creator A5081182943 @default.
• W2123811191 date "2008-10-06" @default.
• W2123811191 modified "2023-10-16" @default.
• W2123811191 title "Altered Cerebral γ-Aminobutyric Acid Type A–Benzodiazepine Receptor Binding in Panic Disorder Determined by [11C]Flumazenil Positron Emission Tomography" @default.
• W2123811191 cites W1635887916 @default.
• W2123811191 cites W1854222635 @default.
• W2123811191 cites W1966996539 @default.
• W2123811191 cites W1976658908 @default.
• W2123811191 cites W1982152081 @default.
• W2123811191 cites W1984577458 @default.
• W2123811191 cites W1985808875 @default.
• W2123811191 cites W1989045560 @default.
• W2123811191 cites W1989615119 @default.
• W2123811191 cites W1991471889 @default.
• W2123811191 cites W1999680640 @default.
• W2123811191 cites W2003090874 @default.
• W2123811191 cites W2011707267 @default.
• W2123811191 cites W2016063613 @default.
• W2123811191 cites W2016512181 @default.
• W2123811191 cites W2017227716 @default.
• W2123811191 cites W2019683883 @default.
• W2123811191 cites W2023866167 @default.
• W2123811191 cites W2025083501 @default.
• W2123811191 cites W2032368198 @default.
• W2123811191 cites W2036583721 @default.
• W2123811191 cites W2038108778 @default.
• W2123811191 cites W2039300800 @default.
• W2123811191 cites W2042520607 @default.
• W2123811191 cites W2046357922 @default.
• W2123811191 cites W2051340164 @default.
• W2123811191 cites W2054121225 @default.
• W2123811191 cites W2062340864 @default.
• W2123811191 cites W2069416181 @default.
• W2123811191 cites W2087519774 @default.
• W2123811191 cites W2088226858 @default.
• W2123811191 cites W2088304086 @default.
• W2123811191 cites W2088880330 @default.
• W2123811191 cites W2093837465 @default.
• W2123811191 cites W2102290181 @default.
• W2123811191 cites W2102308750 @default.
• W2123811191 cites W2110726956 @default.
• W2123811191 cites W2114634718 @default.
• W2123811191 cites W2123233680 @default.
• W2123811191 cites W2124635004 @default.
• W2123811191 cites W2127387181 @default.
• W2123811191 cites W2129028793 @default.
• W2123811191 cites W2129336638 @default.
• W2123811191 cites W2139596642 @default.
• W2123811191 cites W2144906195 @default.
• W2123811191 cites W2158553737 @default.
• W2123811191 cites W2320439911 @default.
• W2123811191 cites W2405050690 @default.
• W2123811191 cites W3127623214 @default.
• W2123811191 cites W33696865 @default.
• W2123811191 cites W1968784545 @default.
• W2123811191 doi "https://doi.org/10.1001/archpsyc.65.10.1166" @default.
• W2123811191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18838633" @default.
• W2123811191 hasPublicationYear "2008" @default.
• W2123811191 type Work @default.
• W2123811191 sameAs 2123811191 @default.
• W2123811191 citedByCount "92" @default.
• W2123811191 countsByYear W21238111912012 @default.
• W2123811191 countsByYear W21238111912013 @default.
• W2123811191 countsByYear W21238111912014 @default.
• W2123811191 countsByYear W21238111912015 @default.
• W2123811191 countsByYear W21238111912016 @default.
• W2123811191 countsByYear W21238111912017 @default.
• W2123811191 countsByYear W21238111912018 @default.
• W2123811191 countsByYear W21238111912019 @default.
• W2123811191 countsByYear W21238111912020 @default.
• W2123811191 countsByYear W21238111912021 @default.
• W2123811191 countsByYear W21238111912022 @default.
• W2123811191 crossrefType "journal-article" @default.
• W2123811191 hasAuthorship W2123811191A5012357230 @default.
• W2123811191 hasAuthorship W2123811191A5029257842 @default.
• W2123811191 hasAuthorship W2123811191A5043955268 @default.
• W2123811191 hasAuthorship W2123811191A5045276496 @default.
• W2123811191 hasAuthorship W2123811191A5065976774 @default.
• W2123811191 hasAuthorship W2123811191A5081182943 @default.
• W2123811191 hasConcept C118552586 @default.
• W2123811191 hasConcept C126322002 @default.
• W2123811191 hasConcept C134018914 @default.
• W2123811191 hasConcept C151730666 @default.
• W2123811191 hasConcept C15744967 @default.
• W2123811191 hasConcept C169760540 @default.
• W2123811191 hasConcept C170493617 @default.
• W2123811191 hasConcept C2775842073 @default.
• W2123811191 hasConcept C2777529043 @default.
• W2123811191 hasConcept C2778173252 @default.
• W2123811191 hasConcept C2778409475 @default.
• W2123811191 hasConcept C2779343474 @default.

• next