FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123815619> ?p ?o ?g. }

• W2123815619 endingPage "1427" @default.
• W2123815619 startingPage "1421" @default.
• W2123815619 abstract "In the pathogenesis of Parkinson’s disease and Huntington’s disease excitotoxicity may play an important role. The common toxin model for Parkinson’s disease is MPTP, while for Huntington’s disease it is 3-NP. These toxins inhibit the mitochondrial respiratory chain, resulting in an energy deficit. In the central nervous system, the amino acids act as neurotransmitters and neuromodulators. The energy deficit caused by these neurotoxins may alter the concentrations of amino acids. Thus, it can be claimed that the aminoacidergic neurotransmission can be changed by neurotoxins. To test this hypothesis we studied the amino acid concentrations in different brain regions following MPTP or 3-NP administration. The two toxins were found to produce similar changes. We detected marked decreases in most of the amino acid concentrations in the striatum and in the cortex, while the levels in the cerebellum increased significantly. The decreased amino acid levels can be explained by the reduced levels of ATP produced by these neurotoxins. In the cerebellum, where there is no detectable ATP loss, the elevated amino acid levels may reflect a compensation of the altered neurotransmission." @default.
• W2123815619 created "2016-06-24" @default.
• W2123815619 creator A5035093314 @default.
• W2123815619 creator A5057094462 @default.
• W2123815619 creator A5057907020 @default.
• W2123815619 creator A5060217047 @default.
• W2123815619 creator A5077240772 @default.
• W2123815619 date "2005-11-01" @default.
• W2123815619 modified "2023-10-18" @default.
• W2123815619 title "Effects of Mitochondrial Toxins on the Brain Amino Acid Concentrations" @default.
• W2123815619 cites W1492679042 @default.
• W2123815619 cites W1563847798 @default.
• W2123815619 cites W1577751913 @default.
• W2123815619 cites W1972591818 @default.
• W2123815619 cites W1985592048 @default.
• W2123815619 cites W1995168736 @default.
• W2123815619 cites W2011520160 @default.
• W2123815619 cites W2036493334 @default.
• W2123815619 cites W2039422369 @default.
• W2123815619 cites W2050472114 @default.
• W2123815619 cites W2054415450 @default.
• W2123815619 cites W2061868171 @default.
• W2123815619 cites W2062604910 @default.
• W2123815619 cites W2075111265 @default.
• W2123815619 cites W2079779237 @default.
• W2123815619 cites W2086129478 @default.
• W2123815619 cites W2089951943 @default.
• W2123815619 cites W2095290615 @default.
• W2123815619 cites W2130826999 @default.
• W2123815619 doi "https://doi.org/10.1007/s11064-005-8512-x" @default.
• W2123815619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16341939" @default.
• W2123815619 hasPublicationYear "2005" @default.
• W2123815619 type Work @default.
• W2123815619 sameAs 2123815619 @default.
• W2123815619 citedByCount "9" @default.
• W2123815619 countsByYear W21238156192013 @default.
• W2123815619 countsByYear W21238156192015 @default.
• W2123815619 countsByYear W21238156192016 @default.
• W2123815619 crossrefType "journal-article" @default.
• W2123815619 hasAuthorship W2123815619A5035093314 @default.
• W2123815619 hasAuthorship W2123815619A5057094462 @default.
• W2123815619 hasAuthorship W2123815619A5057907020 @default.
• W2123815619 hasAuthorship W2123815619A5060217047 @default.
• W2123815619 hasAuthorship W2123815619A5077240772 @default.
• W2123815619 hasBestOaLocation W21238156192 @default.
• W2123815619 hasConcept C126322002 @default.
• W2123815619 hasConcept C134018914 @default.
• W2123815619 hasConcept C137183658 @default.
• W2123815619 hasConcept C170493617 @default.
• W2123815619 hasConcept C200170125 @default.
• W2123815619 hasConcept C2778674702 @default.
• W2123815619 hasConcept C2779652256 @default.
• W2123815619 hasConcept C2780062018 @default.
• W2123815619 hasConcept C2780358027 @default.
• W2123815619 hasConcept C2781012912 @default.
• W2123815619 hasConcept C28859421 @default.
• W2123815619 hasConcept C513476851 @default.
• W2123815619 hasConcept C515207424 @default.
• W2123815619 hasConcept C55493867 @default.
• W2123815619 hasConcept C61174792 @default.
• W2123815619 hasConcept C71924100 @default.
• W2123815619 hasConcept C86803240 @default.
• W2123815619 hasConceptScore W2123815619C126322002 @default.
• W2123815619 hasConceptScore W2123815619C134018914 @default.
• W2123815619 hasConceptScore W2123815619C137183658 @default.
• W2123815619 hasConceptScore W2123815619C170493617 @default.
• W2123815619 hasConceptScore W2123815619C200170125 @default.
• W2123815619 hasConceptScore W2123815619C2778674702 @default.
• W2123815619 hasConceptScore W2123815619C2779652256 @default.
• W2123815619 hasConceptScore W2123815619C2780062018 @default.
• W2123815619 hasConceptScore W2123815619C2780358027 @default.
• W2123815619 hasConceptScore W2123815619C2781012912 @default.
• W2123815619 hasConceptScore W2123815619C28859421 @default.
• W2123815619 hasConceptScore W2123815619C513476851 @default.
• W2123815619 hasConceptScore W2123815619C515207424 @default.
• W2123815619 hasConceptScore W2123815619C55493867 @default.
• W2123815619 hasConceptScore W2123815619C61174792 @default.
• W2123815619 hasConceptScore W2123815619C71924100 @default.
• W2123815619 hasConceptScore W2123815619C86803240 @default.
• W2123815619 hasIssue "11" @default.
• W2123815619 hasLocation W21238156191 @default.
• W2123815619 hasLocation W21238156192 @default.
• W2123815619 hasLocation W21238156193 @default.
• W2123815619 hasOpenAccess W2123815619 @default.
• W2123815619 hasPrimaryLocation W21238156191 @default.
• W2123815619 hasRelatedWork W2005285478 @default.
• W2123815619 hasRelatedWork W2027288915 @default.
• W2123815619 hasRelatedWork W2027845524 @default.
• W2123815619 hasRelatedWork W2039310755 @default.
• W2123815619 hasRelatedWork W2043669439 @default.
• W2123815619 hasRelatedWork W2067222221 @default.
• W2123815619 hasRelatedWork W2073022545 @default.
• W2123815619 hasRelatedWork W2086129478 @default.
• W2123815619 hasRelatedWork W2123815619 @default.
• W2123815619 hasRelatedWork W2321601164 @default.
• W2123815619 hasVolume "30" @default.
• W2123815619 isParatext "false" @default.
• W2123815619 isRetracted "false" @default.

• next