Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123841921> ?p ?o ?g. }
- W2123841921 endingPage "571" @default.
- W2123841921 startingPage "561" @default.
- W2123841921 abstract "Epithelial cadherin (E-cadherin) has been involved in several calcium-dependent cell–cell adhesion events; however, its participation in gamete interaction has not been fully investigated. Our results have demonstrated expression of E-cadherin mRNA in the human male reproductive tract showing higher levels in the caput, corpus and cauda epididymis than in the testis. The mature 122 kDa E-cadherin was detected in epididymal protein extracts and was localized in the epithelial cells from the three epididymal regions. Moreover, the 86 kDa E-cadherin ectodomain was found in cauda epididymal and seminal plasma. Western immunoblotting of human sperm protein extracts allowed the identification of four E-cadherin forms (122, 105, 97 and 86 kDa). The protein was localized in the acrosomal region of intact spermatozoa, remained associated with the head of acrosome-reacted cells and was also detected on the oocyte surface. A similar localization was determined for other proteins of the adhesion complex (β-catenin and actin). Spermatozoa incubated with anti-E-cadherin antibodies showed impaired binding to homologous zona pellucida (ZP); in addition, presence of these antibodies inhibited the penetration of human spermatozoa to ZP-free hamster oocytes. The results presented here describe the expression of E-cadherin in the male reproductive tract and gametes and strongly suggest its involvement in adhesion events during human fertilization. The identification of proteins involved in gamete interaction will contribute to the understanding of the molecular basis of fertilization and help in the diagnosis and treatment of infertility." @default.
- W2123841921 created "2016-06-24" @default.
- W2123841921 creator A5028427590 @default.
- W2123841921 creator A5033259163 @default.
- W2123841921 creator A5051271371 @default.
- W2123841921 creator A5064310275 @default.
- W2123841921 creator A5067156203 @default.
- W2123841921 creator A5079010034 @default.
- W2123841921 date "2008-08-20" @default.
- W2123841921 modified "2023-10-14" @default.
- W2123841921 title "Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization" @default.
- W2123841921 cites W1500478148 @default.
- W2123841921 cites W1538532742 @default.
- W2123841921 cites W1856143987 @default.
- W2123841921 cites W1919303367 @default.
- W2123841921 cites W1970253943 @default.
- W2123841921 cites W1971383813 @default.
- W2123841921 cites W1972039621 @default.
- W2123841921 cites W1978609854 @default.
- W2123841921 cites W1979047519 @default.
- W2123841921 cites W1984865400 @default.
- W2123841921 cites W1985115511 @default.
- W2123841921 cites W1985333754 @default.
- W2123841921 cites W1987357218 @default.
- W2123841921 cites W1988714320 @default.
- W2123841921 cites W1990215042 @default.
- W2123841921 cites W1991725063 @default.
- W2123841921 cites W1996750562 @default.
- W2123841921 cites W1998065958 @default.
- W2123841921 cites W2000132958 @default.
- W2123841921 cites W2000209715 @default.
- W2123841921 cites W2010296172 @default.
- W2123841921 cites W2011612201 @default.
- W2123841921 cites W2012750095 @default.
- W2123841921 cites W2020514343 @default.
- W2123841921 cites W2021754267 @default.
- W2123841921 cites W2022837761 @default.
- W2123841921 cites W2039445668 @default.
- W2123841921 cites W2046785328 @default.
- W2123841921 cites W2052483273 @default.
- W2123841921 cites W2053758478 @default.
- W2123841921 cites W2062086261 @default.
- W2123841921 cites W2064161025 @default.
- W2123841921 cites W2071704383 @default.
- W2123841921 cites W2074018262 @default.
- W2123841921 cites W2078862404 @default.
- W2123841921 cites W2082183844 @default.
- W2123841921 cites W2082348097 @default.
- W2123841921 cites W2084457841 @default.
- W2123841921 cites W2085370249 @default.
- W2123841921 cites W2089003364 @default.
- W2123841921 cites W2115362831 @default.
- W2123841921 cites W2119593627 @default.
- W2123841921 cites W2121439103 @default.
- W2123841921 cites W2121870547 @default.
- W2123841921 cites W2122072787 @default.
- W2123841921 cites W2123732614 @default.
- W2123841921 cites W2125285974 @default.
- W2123841921 cites W2129840495 @default.
- W2123841921 cites W2137186282 @default.
- W2123841921 cites W2142576961 @default.
- W2123841921 cites W2153742494 @default.
- W2123841921 cites W2159624278 @default.
- W2123841921 cites W2160240715 @default.
- W2123841921 cites W2162208736 @default.
- W2123841921 cites W2171746866 @default.
- W2123841921 cites W2172047593 @default.
- W2123841921 cites W2172160601 @default.
- W2123841921 cites W2175151170 @default.
- W2123841921 cites W2325999030 @default.
- W2123841921 cites W4236236547 @default.
- W2123841921 cites W4293316382 @default.
- W2123841921 doi "https://doi.org/10.1093/molehr/gan053" @default.
- W2123841921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18829448" @default.
- W2123841921 hasPublicationYear "2008" @default.
- W2123841921 type Work @default.
- W2123841921 sameAs 2123841921 @default.
- W2123841921 citedByCount "30" @default.
- W2123841921 countsByYear W21238419212012 @default.
- W2123841921 countsByYear W21238419212013 @default.
- W2123841921 countsByYear W21238419212014 @default.
- W2123841921 countsByYear W21238419212015 @default.
- W2123841921 countsByYear W21238419212016 @default.
- W2123841921 countsByYear W21238419212017 @default.
- W2123841921 countsByYear W21238419212018 @default.
- W2123841921 countsByYear W21238419212019 @default.
- W2123841921 countsByYear W21238419212020 @default.
- W2123841921 countsByYear W21238419212021 @default.
- W2123841921 countsByYear W21238419212022 @default.
- W2123841921 crossrefType "journal-article" @default.
- W2123841921 hasAuthorship W2123841921A5028427590 @default.
- W2123841921 hasAuthorship W2123841921A5033259163 @default.
- W2123841921 hasAuthorship W2123841921A5051271371 @default.
- W2123841921 hasAuthorship W2123841921A5064310275 @default.
- W2123841921 hasAuthorship W2123841921A5067156203 @default.
- W2123841921 hasAuthorship W2123841921A5079010034 @default.
- W2123841921 hasBestOaLocation W21238419212 @default.
- W2123841921 hasConcept C1491633281 @default.