FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123871864> ?p ?o ?g. }

• W2123871864 endingPage "E341" @default.
• W2123871864 startingPage "E336" @default.
• W2123871864 abstract "Serum- and glucocorticoid-regulated kinase-1 (SGK1) is a glucocorticoid early-response gene; its function, however, has been elucidated mainly in the context of mineralocorticoid signaling. Here, we investigate the expression and function of SGK1 in the pituitary gland, one of the primary glucocorticoid targets. SGK1 is expressed in the human pituitary gland and colocalizes to ACTH. The AtT-20 murine corticotroph cell line was used for functional experiments. Glucocorticoids upregulated SGK1 mRNA and protein levels, parallel to decreasing proopiomelanocortin (POMC) transcription and ACTH release. Dexamethasone-induced changes in SGK1 protein were abolished by the steroid receptor antagonist RU-486 and reduced by the inhibition of PI 3-kinase with LY-294002. SGK1 overexpression increased CREB- and activator protein-1-dependent transcription, POMC transcription, and ACTH secretion but did not influence intracellular cAMP levels. SGK1 overexpression and corticotropin-releasing hormone had additive effects on POMC promoter activity but not on ACTH secretion. SGK1 knockdown by RNA interference decreased POMC promoter activity, demonstrating the importance of SGK1 for basal POMC signaling. In summary, SGK1 is strongly stimulated by glucocorticoids in pituitary corticotrophs; however, its effects on POMC transcription are antagonistic to the classical inhibitory glucocorticoid action, suggesting a cell-regulated counterregulatory mechanism to potentially detrimental glucocorticoid effects." @default.
• W2123871864 created "2016-06-24" @default.
• W2123871864 creator A5007444625 @default.
• W2123871864 creator A5027428061 @default.
• W2123871864 creator A5038210005 @default.
• W2123871864 creator A5046192813 @default.
• W2123871864 creator A5046330265 @default.
• W2123871864 creator A5055608939 @default.
• W2123871864 creator A5084221051 @default.
• W2123871864 date "2011-08-01" @default.
• W2123871864 modified "2023-09-25" @default.
• W2123871864 title "Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release" @default.
• W2123871864 cites W1230182988 @default.
• W2123871864 cites W1965374041 @default.
• W2123871864 cites W1972101843 @default.
• W2123871864 cites W1977510226 @default.
• W2123871864 cites W1977518774 @default.
• W2123871864 cites W1985562808 @default.
• W2123871864 cites W1991940012 @default.
• W2123871864 cites W1997986332 @default.
• W2123871864 cites W2007530728 @default.
• W2123871864 cites W2055335169 @default.
• W2123871864 cites W2060189309 @default.
• W2123871864 cites W2103944866 @default.
• W2123871864 cites W2109735640 @default.
• W2123871864 cites W2111123535 @default.
• W2123871864 cites W2129976875 @default.
• W2123871864 cites W2162193671 @default.
• W2123871864 cites W2169494292 @default.
• W2123871864 cites W4253861185 @default.
• W2123871864 doi "https://doi.org/10.1152/ajpendo.00155.2011" @default.
• W2123871864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21586695" @default.
• W2123871864 hasPublicationYear "2011" @default.
• W2123871864 type Work @default.
• W2123871864 sameAs 2123871864 @default.
• W2123871864 citedByCount "13" @default.
• W2123871864 countsByYear W21238718642012 @default.
• W2123871864 countsByYear W21238718642013 @default.
• W2123871864 countsByYear W21238718642014 @default.
• W2123871864 countsByYear W21238718642015 @default.
• W2123871864 countsByYear W21238718642018 @default.
• W2123871864 countsByYear W21238718642022 @default.
• W2123871864 crossrefType "journal-article" @default.
• W2123871864 hasAuthorship W2123871864A5007444625 @default.
• W2123871864 hasAuthorship W2123871864A5027428061 @default.
• W2123871864 hasAuthorship W2123871864A5038210005 @default.
• W2123871864 hasAuthorship W2123871864A5046192813 @default.
• W2123871864 hasAuthorship W2123871864A5046330265 @default.
• W2123871864 hasAuthorship W2123871864A5055608939 @default.
• W2123871864 hasAuthorship W2123871864A5084221051 @default.
• W2123871864 hasConcept C104317684 @default.
• W2123871864 hasConcept C126322002 @default.
• W2123871864 hasConcept C134018914 @default.
• W2123871864 hasConcept C1629964 @default.
• W2123871864 hasConcept C177865409 @default.
• W2123871864 hasConcept C184150571 @default.
• W2123871864 hasConcept C184235292 @default.
• W2123871864 hasConcept C2779029589 @default.
• W2123871864 hasConcept C2780546910 @default.
• W2123871864 hasConcept C2780841215 @default.
• W2123871864 hasConcept C2781309135 @default.
• W2123871864 hasConcept C55493867 @default.
• W2123871864 hasConcept C59493245 @default.
• W2123871864 hasConcept C71315377 @default.
• W2123871864 hasConcept C71924100 @default.
• W2123871864 hasConcept C79381400 @default.
• W2123871864 hasConcept C86339819 @default.
• W2123871864 hasConcept C86803240 @default.
• W2123871864 hasConcept C95444343 @default.
• W2123871864 hasConcept C97029542 @default.
• W2123871864 hasConceptScore W2123871864C104317684 @default.
• W2123871864 hasConceptScore W2123871864C126322002 @default.
• W2123871864 hasConceptScore W2123871864C134018914 @default.
• W2123871864 hasConceptScore W2123871864C1629964 @default.
• W2123871864 hasConceptScore W2123871864C177865409 @default.
• W2123871864 hasConceptScore W2123871864C184150571 @default.
• W2123871864 hasConceptScore W2123871864C184235292 @default.
• W2123871864 hasConceptScore W2123871864C2779029589 @default.
• W2123871864 hasConceptScore W2123871864C2780546910 @default.
• W2123871864 hasConceptScore W2123871864C2780841215 @default.
• W2123871864 hasConceptScore W2123871864C2781309135 @default.
• W2123871864 hasConceptScore W2123871864C55493867 @default.
• W2123871864 hasConceptScore W2123871864C59493245 @default.
• W2123871864 hasConceptScore W2123871864C71315377 @default.
• W2123871864 hasConceptScore W2123871864C71924100 @default.
• W2123871864 hasConceptScore W2123871864C79381400 @default.
• W2123871864 hasConceptScore W2123871864C86339819 @default.
• W2123871864 hasConceptScore W2123871864C86803240 @default.
• W2123871864 hasConceptScore W2123871864C95444343 @default.
• W2123871864 hasConceptScore W2123871864C97029542 @default.
• W2123871864 hasIssue "2" @default.
• W2123871864 hasLocation W21238718641 @default.
• W2123871864 hasLocation W21238718642 @default.
• W2123871864 hasOpenAccess W2123871864 @default.
• W2123871864 hasPrimaryLocation W21238718641 @default.
• W2123871864 hasRelatedWork W1996440026 @default.
• W2123871864 hasRelatedWork W2024618244 @default.
• W2123871864 hasRelatedWork W2045253667 @default.

• next