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- W2123880844 endingPage "148" @default.
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- W2123880844 abstract "Cell signaling systems that contain positive-feedback loops or double-negative feedback loops can, in principle, convert graded inputs into switch-like, irreversible responses. Systems of this sort are termed bistable. Recently, several groups have engineered artificial bistable systems into Escherichia coli and Saccharomyces cerevisiae, and have shown that the systems exhibit interesting and potentially useful properties. In addition, two naturally occurring signaling systems, the p42 mitogen-activated protein kinase and c-Jun amino-terminal kinase pathways in Xenopus oocytes, have been shown to exhibit bistable responses. Here we review the basic properties of bistable circuits, the requirements for construction of a satisfactory bistable switch, and the recent progress towards constructing and analysing bistable signaling systems." @default.
- W2123880844 created "2016-06-24" @default.
- W2123880844 creator A5007372909 @default.
- W2123880844 date "2002-04-01" @default.
- W2123880844 modified "2023-10-14" @default.
- W2123880844 title "Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability" @default.
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- W2123880844 doi "https://doi.org/10.1016/s0955-0674(02)00314-9" @default.
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