FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123901615> ?p ?o ?g. }

• W2123901615 abstract "Host adhesion molecules play a significant role in the pathogenesis of Plasmodium falciparum malaria and changes in their structure or levels in individuals can influence the outcome of infection. The aim of this study was to investigate the association of SNPs of three adhesion molecule genes, ICAM1, PECAM1 and CD36, with severity of falciparum malaria in a malaria-endemic and a non-endemic region of India.The frequency distribution of seven selected SNPs of ICAM1, PECAM1 and CD36 was determined in 552 individuals drawn from 24 populations across India. SNP-disease association was analysed in a case-control study format. Genotyping of the population panel was performed by Sequenom mass spectroscopy and patient/control samples were genotyped by SNaPshot method. Haplotypes and linkage disequilibrium (LD) plots were generated using PHASE and Haploview, respectively. Odds-ratio (OR) for risk assessment was estimated using EpiInfotrade mark version 3.4.Association of the ICAM1 rs5498 (exon 6) G allele and the CD36 exon 1a A allele with increased risk of severe malaria was observed (severe versus control, OR = 1.91 and 2.66, P = 0.02 and 0.0012, respectively). The CD36 rs1334512 (-53) T allele as well as the TT genotype associated with protection from severe disease (severe versus control, TT versus GG, OR = 0.37, P = 0.004). Interestingly, a SNP of the PECAM1 gene (rs668, exon 3, C/G) with low minor allele frequency in populations of the endemic region compared to the non-endemic region exhibited differential association with disease in these regions; the G allele was a risk factor for malaria in the endemic region, but exhibited significant association with protection from disease in the non-endemic region.The data highlights the significance of variations in the ICAM1, PECAM1 and CD36 genes in the manifestation of falciparum malaria in India. The PECAM1 exon 3 SNP exhibits altered association with disease in the endemic and non-endemic region." @default.
• W2123901615 created "2016-06-24" @default.
• W2123901615 creator A5004982852 @default.
• W2123901615 creator A5007697425 @default.
• W2123901615 creator A5007727285 @default.
• W2123901615 creator A5017413200 @default.
• W2123901615 creator A5025750533 @default.
• W2123901615 creator A5040068106 @default.
• W2123901615 creator A5042003496 @default.
• W2123901615 creator A5053199023 @default.
• W2123901615 creator A5063418352 @default.
• W2123901615 creator A5070455104 @default.
• W2123901615 creator A5077948322 @default.
• W2123901615 creator A5084190959 @default.
• W2123901615 date "2008-12-01" @default.
• W2123901615 modified "2023-10-15" @default.
• W2123901615 title "Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India" @default.
• W2123901615 cites W1230104293 @default.
• W2123901615 cites W1499483096 @default.
• W2123901615 cites W1526673237 @default.
• W2123901615 cites W1566477377 @default.
• W2123901615 cites W1601945803 @default.
• W2123901615 cites W1837680741 @default.
• W2123901615 cites W1975528993 @default.
• W2123901615 cites W1984840918 @default.
• W2123901615 cites W1991873268 @default.
• W2123901615 cites W1993756013 @default.
• W2123901615 cites W2001978229 @default.
• W2123901615 cites W2011178652 @default.
• W2123901615 cites W2012028324 @default.
• W2123901615 cites W2027397742 @default.
• W2123901615 cites W2037672200 @default.
• W2123901615 cites W2042421292 @default.
• W2123901615 cites W2043394305 @default.
• W2123901615 cites W2043418529 @default.
• W2123901615 cites W2043894008 @default.
• W2123901615 cites W2046013935 @default.
• W2123901615 cites W2073744746 @default.
• W2123901615 cites W2074229518 @default.
• W2123901615 cites W2074236845 @default.
• W2123901615 cites W2076544464 @default.
• W2123901615 cites W2084229888 @default.
• W2123901615 cites W2101688560 @default.
• W2123901615 cites W2109342412 @default.
• W2123901615 cites W2112706257 @default.
• W2123901615 cites W2113682801 @default.
• W2123901615 cites W2117131435 @default.
• W2123901615 cites W2117302340 @default.
• W2123901615 cites W2118094114 @default.
• W2123901615 cites W2138653622 @default.
• W2123901615 cites W2140539159 @default.
• W2123901615 cites W2160521193 @default.
• W2123901615 cites W2161212531 @default.
• W2123901615 cites W2168358106 @default.
• W2123901615 cites W2170247491 @default.
• W2123901615 cites W2185570373 @default.
• W2123901615 cites W2315349119 @default.
• W2123901615 cites W2419002114 @default.
• W2123901615 cites W2506062421 @default.
• W2123901615 cites W2770852300 @default.
• W2123901615 cites W4211010162 @default.
• W2123901615 cites W958237954 @default.
• W2123901615 doi "https://doi.org/10.1186/1475-2875-7-250" @default.
• W2123901615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612678" @default.
• W2123901615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19055786" @default.
• W2123901615 hasPublicationYear "2008" @default.
• W2123901615 type Work @default.
• W2123901615 sameAs 2123901615 @default.
• W2123901615 citedByCount "47" @default.
• W2123901615 countsByYear W21239016152012 @default.
• W2123901615 countsByYear W21239016152013 @default.
• W2123901615 countsByYear W21239016152014 @default.
• W2123901615 countsByYear W21239016152015 @default.
• W2123901615 countsByYear W21239016152016 @default.
• W2123901615 countsByYear W21239016152017 @default.
• W2123901615 countsByYear W21239016152018 @default.
• W2123901615 countsByYear W21239016152019 @default.
• W2123901615 countsByYear W21239016152020 @default.
• W2123901615 countsByYear W21239016152021 @default.
• W2123901615 countsByYear W21239016152022 @default.
• W2123901615 countsByYear W21239016152023 @default.
• W2123901615 crossrefType "journal-article" @default.
• W2123901615 hasAuthorship W2123901615A5004982852 @default.
• W2123901615 hasAuthorship W2123901615A5007697425 @default.
• W2123901615 hasAuthorship W2123901615A5007727285 @default.
• W2123901615 hasAuthorship W2123901615A5017413200 @default.
• W2123901615 hasAuthorship W2123901615A5025750533 @default.
• W2123901615 hasAuthorship W2123901615A5040068106 @default.
• W2123901615 hasAuthorship W2123901615A5042003496 @default.
• W2123901615 hasAuthorship W2123901615A5053199023 @default.
• W2123901615 hasAuthorship W2123901615A5063418352 @default.
• W2123901615 hasAuthorship W2123901615A5070455104 @default.
• W2123901615 hasAuthorship W2123901615A5077948322 @default.
• W2123901615 hasAuthorship W2123901615A5084190959 @default.
• W2123901615 hasBestOaLocation W21239016151 @default.
• W2123901615 hasConcept C104317684 @default.
• W2123901615 hasConcept C135763542 @default.
• W2123901615 hasConcept C139275648 @default.
• W2123901615 hasConcept C153209595 @default.
• W2123901615 hasConcept C157410074 @default.

• next