FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123912912> ?p ?o ?g. }

• W2123912912 endingPage "1396" @default.
• W2123912912 startingPage "1388" @default.
• W2123912912 abstract "Abstract A better understanding of the mechanisms of nerve regeneration could improve the outcome of surgical nerve repair. We have previously shown that axonal regeneration is increased by nerve growth factor. Neurotrophin‐3 (NT‐3) belongs to the same family as nerve growth factor but acts on a distinct neuron subpopulation. As little is known about its role following nerve injury, we have investigated the effect of NT‐3 delivered via fibronectin mats, previously shown to support nerve regeneration comparable to nerve grafts. NT‐3 stimulation (0.1–1000 ng/ml) of neurite extension from embryonic chick dorsal root ganglia in vitro has shown that fibronectin can bind and release bioactive NT‐3. Fibronectin mats impregnated with NT‐3 (500 ng/ml) were grafted into 1 cm sciatic nerve defects in adult Lewis rats. Plain mats were used as controls. Computerized quantification of penetration distance, volume of axonal regeneration and myelinated fibre counts was undertaken using immunostaining for axonal markers (growth‐associated protein 43, calcitonin gene‐related peptide, substance P, vasoactive intestinal peptide and neuropeptide tyrosine), or S100 orthionine blue staining up to 8 months postoperatively. The maximal effect of NT‐3 occurred at day 15, when for GAP43‐immunostained axons both penetration distance (NT‐3, 6.10 ± 0.42 mm; control, 4.11 ± 0.41 mm; P <0.01) and staining area (NT‐3, 0.137 ± 0.012 mm 2 ; control, 0.077 ± 0.018 mm 2 ; P < 0.05) were significantly increased. Similar results were found for each neuronal subpopulation investigated. By 8 months after repair, the NT‐3 group supported a significantly greater number of myelinated axons (NT‐3, 7003 ± 402; control, 4932 ± 725; P < 0.05) of similar diameter and g‐ratio to controls. These results demonstrate the contribution of NT‐3 to the increase of nerve regeneration promoted by growth factors." @default.
• W2123912912 created "2016-06-24" @default.
• W2123912912 creator A5026570774 @default.
• W2123912912 creator A5075149449 @default.
• W2123912912 creator A5082599655 @default.
• W2123912912 creator A5085100888 @default.
• W2123912912 date "1997-07-01" @default.
• W2123912912 modified "2023-10-18" @default.
• W2123912912 title "Neurotrophin-3 Delivered Locally via Fibronectin Mats Enhances Peripheral Nerve Regeneration" @default.
• W2123912912 cites W1496712622 @default.
• W2123912912 cites W1521573047 @default.
• W2123912912 cites W1527035699 @default.
• W2123912912 cites W1527229950 @default.
• W2123912912 cites W1714355435 @default.
• W2123912912 cites W1832821166 @default.
• W2123912912 cites W1972707997 @default.
• W2123912912 cites W1974572588 @default.
• W2123912912 cites W1974675951 @default.
• W2123912912 cites W1978300767 @default.
• W2123912912 cites W1979028576 @default.
• W2123912912 cites W1979075898 @default.
• W2123912912 cites W1980021607 @default.
• W2123912912 cites W1987628941 @default.
• W2123912912 cites W1998884668 @default.
• W2123912912 cites W2001729304 @default.
• W2123912912 cites W2002422337 @default.
• W2123912912 cites W2003224769 @default.
• W2123912912 cites W2005119948 @default.
• W2123912912 cites W2011772807 @default.
• W2123912912 cites W2022662543 @default.
• W2123912912 cites W2026067024 @default.
• W2123912912 cites W2027818105 @default.
• W2123912912 cites W2030258291 @default.
• W2123912912 cites W2030998945 @default.
• W2123912912 cites W2031093094 @default.
• W2123912912 cites W2034127040 @default.
• W2123912912 cites W2039190417 @default.
• W2123912912 cites W2043686725 @default.
• W2123912912 cites W2050838682 @default.
• W2123912912 cites W2053763360 @default.
• W2123912912 cites W2057250008 @default.
• W2123912912 cites W2058650902 @default.
• W2123912912 cites W2063012509 @default.
• W2123912912 cites W2066790769 @default.
• W2123912912 cites W2070927514 @default.
• W2123912912 cites W2080880626 @default.
• W2123912912 cites W2082739481 @default.
• W2123912912 cites W2082805021 @default.
• W2123912912 cites W2083851795 @default.
• W2123912912 cites W2086159324 @default.
• W2123912912 cites W2089454493 @default.
• W2123912912 cites W2089640725 @default.
• W2123912912 cites W2091448816 @default.
• W2123912912 cites W2101433654 @default.
• W2123912912 cites W2108995746 @default.
• W2123912912 cites W2110301830 @default.
• W2123912912 cites W2110795584 @default.
• W2123912912 cites W2111479567 @default.
• W2123912912 cites W2149761830 @default.
• W2123912912 cites W2153199767 @default.
• W2123912912 doi "https://doi.org/10.1111/j.1460-9568.1997.tb01493.x" @default.
• W2123912912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9240396" @default.
• W2123912912 hasPublicationYear "1997" @default.
• W2123912912 type Work @default.
• W2123912912 sameAs 2123912912 @default.
• W2123912912 citedByCount "161" @default.
• W2123912912 countsByYear W21239129122012 @default.
• W2123912912 countsByYear W21239129122013 @default.
• W2123912912 countsByYear W21239129122014 @default.
• W2123912912 countsByYear W21239129122015 @default.
• W2123912912 countsByYear W21239129122016 @default.
• W2123912912 countsByYear W21239129122017 @default.
• W2123912912 countsByYear W21239129122018 @default.
• W2123912912 countsByYear W21239129122019 @default.
• W2123912912 countsByYear W21239129122020 @default.
• W2123912912 countsByYear W21239129122021 @default.
• W2123912912 countsByYear W21239129122023 @default.
• W2123912912 crossrefType "journal-article" @default.
• W2123912912 hasAuthorship W2123912912A5026570774 @default.
• W2123912912 hasAuthorship W2123912912A5075149449 @default.
• W2123912912 hasAuthorship W2123912912A5082599655 @default.
• W2123912912 hasAuthorship W2123912912A5085100888 @default.
• W2123912912 hasConcept C105702510 @default.
• W2123912912 hasConcept C113246987 @default.
• W2123912912 hasConcept C118303440 @default.
• W2123912912 hasConcept C126322002 @default.
• W2123912912 hasConcept C135903288 @default.
• W2123912912 hasConcept C160539049 @default.
• W2123912912 hasConcept C163170386 @default.
• W2123912912 hasConcept C170493617 @default.
• W2123912912 hasConcept C171056886 @default.
• W2123912912 hasConcept C185592680 @default.
• W2123912912 hasConcept C189165786 @default.
• W2123912912 hasConcept C202751555 @default.
• W2123912912 hasConcept C204232928 @default.
• W2123912912 hasConcept C2778423431 @default.
• W2123912912 hasConcept C2778790584 @default.
• W2123912912 hasConcept C2779456298 @default.

• next