FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123939031> ?p ?o ?g. }

• W2123939031 endingPage "e70732" @default.
• W2123939031 startingPage "e70732" @default.
• W2123939031 abstract "Platelets during storage undergo diverse alterations collectively known as the platelet storage lesion, including metabolic, morphological, functional and structural changes. Some changes correlate with activation of p38 mitogen activated protein kinase (p38 MAPK). Another MAPK, extracellular signal-related kinase (ERK), is involved in PLT activation. The aim of this study was to compare the properties of platelets stored in plasma in the presence or absence of p38 and ERK MAPK inhibitors.A single Trima apheresis platelet unit (n = 12) was aliquoted into five CLX storage bags. Two aliquots were continuously agitated with or without MAPK inhibitors. Two aliquots were subjected to 48 hours of interruption of agitation with or without MAPK inhibitors. One aliquot contained the same amount of solvent vehicle used to deliver the inhibitor. Platelets were stored at 20-24°C for 7 days and sampled on Days 1, 4, and 7 for 18 in vitro parameters.Inhibition of p38 MAPK by VX-702 leads to better maintenance of all platelet in vitro storage parameters including platelet mitochondrial function. Accelerated by interruption of agitation, the platelet storage lesion of units stored with VX-702 was diminished to that of platelets stored with continuous agitation. Inhibition of ERK MAPK did not ameliorate decrements in any in vitro platelet properties.Signaling through p38 MAPK, but not ERK, is associated with platelet deterioration during storage." @default.
• W2123939031 created "2016-06-24" @default.
• W2123939031 creator A5008997701 @default.
• W2123939031 creator A5049424344 @default.
• W2123939031 creator A5063637116 @default.
• W2123939031 creator A5077621033 @default.
• W2123939031 creator A5083439920 @default.
• W2123939031 creator A5085260523 @default.
• W2123939031 date "2013-08-13" @default.
• W2123939031 modified "2023-10-16" @default.
• W2123939031 title "An Inhibition of p38 Mitogen Activated Protein Kinase Delays the Platelet Storage Lesion" @default.
• W2123939031 cites W1489245211 @default.
• W2123939031 cites W1968287882 @default.
• W2123939031 cites W1969017869 @default.
• W2123939031 cites W1979222495 @default.
• W2123939031 cites W1986454658 @default.
• W2123939031 cites W2000073370 @default.
• W2123939031 cites W2006751790 @default.
• W2123939031 cites W2010738078 @default.
• W2123939031 cites W2011124873 @default.
• W2123939031 cites W2013828143 @default.
• W2123939031 cites W2018036144 @default.
• W2123939031 cites W2026314750 @default.
• W2123939031 cites W2039099155 @default.
• W2123939031 cites W2043895689 @default.
• W2123939031 cites W2046686790 @default.
• W2123939031 cites W2052823603 @default.
• W2123939031 cites W2072124401 @default.
• W2123939031 cites W2085272864 @default.
• W2123939031 cites W2086758383 @default.
• W2123939031 cites W2092037329 @default.
• W2123939031 cites W2093379009 @default.
• W2123939031 cites W2098881788 @default.
• W2123939031 cites W2101721636 @default.
• W2123939031 cites W2107495112 @default.
• W2123939031 cites W2111191758 @default.
• W2123939031 cites W2112345709 @default.
• W2123939031 cites W2117811396 @default.
• W2123939031 cites W2134152071 @default.
• W2123939031 cites W2138666676 @default.
• W2123939031 cites W2140639765 @default.
• W2123939031 cites W2148090385 @default.
• W2123939031 cites W2149848093 @default.
• W2123939031 cites W2162376045 @default.
• W2123939031 cites W2164507878 @default.
• W2123939031 cites W4241887883 @default.
• W2123939031 cites W56507834 @default.
• W2123939031 doi "https://doi.org/10.1371/journal.pone.0070732" @default.
• W2123939031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742641" @default.
• W2123939031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23967093" @default.
• W2123939031 hasPublicationYear "2013" @default.
• W2123939031 type Work @default.
• W2123939031 sameAs 2123939031 @default.
• W2123939031 citedByCount "22" @default.
• W2123939031 countsByYear W21239390312013 @default.
• W2123939031 countsByYear W21239390312014 @default.
• W2123939031 countsByYear W21239390312015 @default.
• W2123939031 countsByYear W21239390312016 @default.
• W2123939031 countsByYear W21239390312017 @default.
• W2123939031 countsByYear W21239390312018 @default.
• W2123939031 countsByYear W21239390312020 @default.
• W2123939031 countsByYear W21239390312021 @default.
• W2123939031 countsByYear W21239390312022 @default.
• W2123939031 countsByYear W21239390312023 @default.
• W2123939031 crossrefType "journal-article" @default.
• W2123939031 hasAuthorship W2123939031A5008997701 @default.
• W2123939031 hasAuthorship W2123939031A5049424344 @default.
• W2123939031 hasAuthorship W2123939031A5063637116 @default.
• W2123939031 hasAuthorship W2123939031A5077621033 @default.
• W2123939031 hasAuthorship W2123939031A5083439920 @default.
• W2123939031 hasAuthorship W2123939031A5085260523 @default.
• W2123939031 hasBestOaLocation W21239390311 @default.
• W2123939031 hasConcept C184235292 @default.
• W2123939031 hasConcept C185592680 @default.
• W2123939031 hasConcept C203014093 @default.
• W2123939031 hasConcept C3018697912 @default.
• W2123939031 hasConcept C51551487 @default.
• W2123939031 hasConcept C55493867 @default.
• W2123939031 hasConcept C57074206 @default.
• W2123939031 hasConcept C86803240 @default.
• W2123939031 hasConcept C89560881 @default.
• W2123939031 hasConcept C95444343 @default.
• W2123939031 hasConcept C97029542 @default.
• W2123939031 hasConcept C98274493 @default.
• W2123939031 hasConceptScore W2123939031C184235292 @default.
• W2123939031 hasConceptScore W2123939031C185592680 @default.
• W2123939031 hasConceptScore W2123939031C203014093 @default.
• W2123939031 hasConceptScore W2123939031C3018697912 @default.
• W2123939031 hasConceptScore W2123939031C51551487 @default.
• W2123939031 hasConceptScore W2123939031C55493867 @default.
• W2123939031 hasConceptScore W2123939031C57074206 @default.
• W2123939031 hasConceptScore W2123939031C86803240 @default.
• W2123939031 hasConceptScore W2123939031C89560881 @default.
• W2123939031 hasConceptScore W2123939031C95444343 @default.
• W2123939031 hasConceptScore W2123939031C97029542 @default.
• W2123939031 hasConceptScore W2123939031C98274493 @default.
• W2123939031 hasIssue "8" @default.
• W2123939031 hasLocation W21239390311 @default.

• next