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- W2123947357 abstract "Site-directed mutations involving selected amino acids of Escherichia coli single-stranded DNA-binding protein (SSB) were tested for their in vivo functionality when introduced into a chromosomal ssb deletion strain on a plasmid. All mutants complemented the ssb deletion for viability when present on a pSC101 derivative. The generation time with ssbW54S doubled in comparison to the ssb* control, and both the ssbW54S- and ssbH55K-containing strains exhibited temperature sensitivity. ssbH55K, ssbW54S, ssbW88T, and ssbH55Y (ssb-1) strains displayed reduced survival to ultraviolet irradiation, while ssbW40T and ssbF60L strains were comparable to the ssb+ control strain. This study represents the first investigation of the in vivo properties of ssb mutations constructed for in vitro analysis of DNA binding by SSB." @default.
- W2123947357 created "2016-06-24" @default.
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- W2123947357 date "1993-12-01" @default.
- W2123947357 modified "2023-09-23" @default.
- W2123947357 title "Viability and preliminary in vivo characterization of site directed mutants of Escherichia coli single-stranded DNA-binding protein" @default.
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- W2123947357 doi "https://doi.org/10.1111/j.1365-2958.1993.tb00977.x" @default.
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