FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123947478> ?p ?o ?g. }

• W2123947478 endingPage "36" @default.
• W2123947478 startingPage "30" @default.
• W2123947478 abstract "Type 2 diabetic subjects failing glyburide therapy were randomized to receive additional therapy with either metformin (2,550 mg/day) or troglitazone (600 mg/day) for 3-4 months. Biopsies of subcutaneous abdominal adipose tissue were obtained before and after therapy. Glycemic control was similar with both treatments. Metformin treatment increased insulin-stimulated whole-body glucose disposal rates by 20% (P < 0.05); the response to troglitazone was greater (44% increase, P < 0.01 vs. baseline, P < 0.05 vs. metformin). Troglitazone-treated subjects displayed a tendency toward weight gain (5 +/- 2 kg, P < 0.05), increased adipocyte size, and increased serum leptin levels. Metformin-treated subjects were weight-stable, with unchanged leptin levels and reduced adipocyte size (to 84 +/- 4% of control, P < 0.005). Glucose transport in isolated adipocytes from metformin-treated subjects was unaltered from pretreatment. Glucose transport in both the absence (321 +/- 134% of pre-Rx, P < 0.05) and presence of insulin (418 +/- 161%, P < 0.05) was elevated after troglitazone treatment. Metformin treatment had no effect on adipocyte content of GLUT1 or GLUT4 proteins. After troglitazone treatment, GLUT4 protein expression was increased twofold (202 +/- 42%, P < 0.05). Insulin-stimulated serine phosphorylation of Akt was augmented after troglitazone (170 +/- 34% of pre-Rx response, P < 0.05) treatment and unchanged by metformin. We conclude that the ability of troglitazone to upregulate adipocyte glucose transport, GLUT4 expression, and insulin signaling can contribute to its greater effect on whole-body glucose disposal." @default.
• W2123947478 created "2016-06-24" @default.
• W2123947478 creator A5007363699 @default.
• W2123947478 creator A5008615533 @default.
• W2123947478 creator A5015832857 @default.
• W2123947478 creator A5035596638 @default.
• W2123947478 creator A5045462483 @default.
• W2123947478 creator A5052137530 @default.
• W2123947478 creator A5068241055 @default.
• W2123947478 creator A5073950544 @default.
• W2123947478 creator A5074058456 @default.
• W2123947478 creator A5084708084 @default.
• W2123947478 creator A5089649262 @default.
• W2123947478 date "2002-01-01" @default.
• W2123947478 modified "2023-10-18" @default.
• W2123947478 title "Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects" @default.
• W2123947478 cites W1551443142 @default.
• W2123947478 cites W1867440159 @default.
• W2123947478 cites W1923807681 @default.
• W2123947478 cites W1971981454 @default.
• W2123947478 cites W1979497936 @default.
• W2123947478 cites W1979782841 @default.
• W2123947478 cites W1980672646 @default.
• W2123947478 cites W1982688466 @default.
• W2123947478 cites W1987692887 @default.
• W2123947478 cites W1989376597 @default.
• W2123947478 cites W2000821877 @default.
• W2123947478 cites W2002400514 @default.
• W2123947478 cites W2012943708 @default.
• W2123947478 cites W2027702484 @default.
• W2123947478 cites W2036939737 @default.
• W2123947478 cites W2038715027 @default.
• W2123947478 cites W2044007450 @default.
• W2123947478 cites W2045236907 @default.
• W2123947478 cites W2059692699 @default.
• W2123947478 cites W2085589411 @default.
• W2123947478 cites W2089582113 @default.
• W2123947478 cites W2091339309 @default.
• W2123947478 cites W2091510428 @default.
• W2123947478 cites W2094083698 @default.
• W2123947478 cites W2095173006 @default.
• W2123947478 cites W2095252238 @default.
• W2123947478 cites W2100837269 @default.
• W2123947478 cites W2121210060 @default.
• W2123947478 cites W2122338601 @default.
• W2123947478 cites W2125090169 @default.
• W2123947478 cites W2125344994 @default.
• W2123947478 cites W2126317966 @default.
• W2123947478 cites W2136427955 @default.
• W2123947478 cites W2142504521 @default.
• W2123947478 cites W2143873575 @default.
• W2123947478 cites W2157563219 @default.
• W2123947478 cites W2164884154 @default.
• W2123947478 cites W2165604272 @default.
• W2123947478 cites W2166542068 @default.
• W2123947478 cites W2167628665 @default.
• W2123947478 cites W2169421904 @default.
• W2123947478 cites W2189424535 @default.
• W2123947478 cites W2320006945 @default.
• W2123947478 cites W28879594 @default.
• W2123947478 cites W4230030006 @default.
• W2123947478 cites W4251084194 @default.
• W2123947478 cites W4251148712 @default.
• W2123947478 cites W4256495385 @default.
• W2123947478 doi "https://doi.org/10.2337/diabetes.51.1.30" @default.
• W2123947478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11756319" @default.
• W2123947478 hasPublicationYear "2002" @default.
• W2123947478 type Work @default.
• W2123947478 sameAs 2123947478 @default.
• W2123947478 citedByCount "113" @default.
• W2123947478 countsByYear W21239474782012 @default.
• W2123947478 countsByYear W21239474782013 @default.
• W2123947478 countsByYear W21239474782014 @default.
• W2123947478 countsByYear W21239474782015 @default.
• W2123947478 countsByYear W21239474782016 @default.
• W2123947478 countsByYear W21239474782018 @default.
• W2123947478 countsByYear W21239474782020 @default.
• W2123947478 countsByYear W21239474782021 @default.
• W2123947478 countsByYear W21239474782022 @default.
• W2123947478 countsByYear W21239474782023 @default.
• W2123947478 crossrefType "journal-article" @default.
• W2123947478 hasAuthorship W2123947478A5007363699 @default.
• W2123947478 hasAuthorship W2123947478A5008615533 @default.
• W2123947478 hasAuthorship W2123947478A5015832857 @default.
• W2123947478 hasAuthorship W2123947478A5035596638 @default.
• W2123947478 hasAuthorship W2123947478A5045462483 @default.
• W2123947478 hasAuthorship W2123947478A5052137530 @default.
• W2123947478 hasAuthorship W2123947478A5068241055 @default.
• W2123947478 hasAuthorship W2123947478A5073950544 @default.
• W2123947478 hasAuthorship W2123947478A5074058456 @default.
• W2123947478 hasAuthorship W2123947478A5084708084 @default.
• W2123947478 hasAuthorship W2123947478A5089649262 @default.
• W2123947478 hasBestOaLocation W21239474781 @default.
• W2123947478 hasConcept C126322002 @default.
• W2123947478 hasConcept C134018914 @default.
• W2123947478 hasConcept C161573976 @default.
• W2123947478 hasConcept C170493617 @default.
• W2123947478 hasConcept C171089720 @default.

• next