Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123951330> ?p ?o ?g. }
- W2123951330 endingPage "R1350" @default.
- W2123951330 startingPage "R1343" @default.
- W2123951330 abstract "Sustained fructose consumption has been shown to induce insulin resistance and glucose intolerance, in part, by promoting oxidative stress. Alpha-lipoic acid (LA) is an antioxidant with insulin-sensitizing activity. The effect of sustained fructose consumption (20% of energy) on the development of T2DM and the effects of daily LA supplementation in fructose-fed University of California, Davis-Type 2 diabetes mellitus (UCD-T2DM) rats, a model of polygenic obese T2DM, was investigated. At 2 mo of age, animals were divided into three groups: control, fructose, and fructose + LA (80 mg LA·kg body wt −1 ·day −1 ). One subset was followed until diabetes onset, while another subset was euthanized at 4 mo of age for tissue collection. Monthly fasted blood samples were collected, and an intravenous glucose tolerance test (IVGTT) was performed. Fructose feeding accelerated diabetes onset by 2.6 ± 0.5 mo compared with control ( P < 0.01), without affecting body weight. LA supplementation delayed diabetes onset in fructose-fed animals by 1.0 ± 0.7 mo ( P < 0.05). Fructose consumption lowered the GSH/GSSG ratio, while LA attenuated the fructose-induced decrease of oxidative capacity. Insulin sensitivity, as assessed by IVGTT, decreased in both fructose-fed and fructose + LA-supplemented rats. However, glucose excursions in fructose-fed LA-supplemented animals were normalized to those of control via increased glucose-stimulated insulin secretion. Fasting plasma triglycerides were twofold higher in fructose-fed compared with control animals at 4 mo, and triglyceride exposure during IVGTT was increased in both the fructose and fructose + LA groups compared with control. In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving β-cell function." @default.
- W2123951330 created "2016-06-24" @default.
- W2123951330 creator A5010282554 @default.
- W2123951330 creator A5034829692 @default.
- W2123951330 creator A5035450241 @default.
- W2123951330 creator A5056635157 @default.
- W2123951330 creator A5073614725 @default.
- W2123951330 creator A5081546127 @default.
- W2123951330 creator A5090551785 @default.
- W2123951330 date "2010-05-01" @default.
- W2123951330 modified "2023-09-27" @default.
- W2123951330 title "Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, α-lipoic acid" @default.
- W2123951330 cites W1500747637 @default.
- W2123951330 cites W1577091995 @default.
- W2123951330 cites W1583462726 @default.
- W2123951330 cites W173870843 @default.
- W2123951330 cites W1965696818 @default.
- W2123951330 cites W1967008598 @default.
- W2123951330 cites W1970693113 @default.
- W2123951330 cites W1993435778 @default.
- W2123951330 cites W1997642460 @default.
- W2123951330 cites W2003604699 @default.
- W2123951330 cites W2011823591 @default.
- W2123951330 cites W2018522666 @default.
- W2123951330 cites W2022151858 @default.
- W2123951330 cites W2038873103 @default.
- W2123951330 cites W2041165301 @default.
- W2123951330 cites W2058626978 @default.
- W2123951330 cites W2059467226 @default.
- W2123951330 cites W2073700605 @default.
- W2123951330 cites W2076875306 @default.
- W2123951330 cites W2077467622 @default.
- W2123951330 cites W2080142407 @default.
- W2123951330 cites W2083990676 @default.
- W2123951330 cites W2088208009 @default.
- W2123951330 cites W2105470307 @default.
- W2123951330 cites W2107996795 @default.
- W2123951330 cites W2108672863 @default.
- W2123951330 cites W2114952735 @default.
- W2123951330 cites W2116133877 @default.
- W2123951330 cites W2119807178 @default.
- W2123951330 cites W2120000106 @default.
- W2123951330 cites W2124655674 @default.
- W2123951330 cites W2136913126 @default.
- W2123951330 cites W2143873575 @default.
- W2123951330 cites W2146966453 @default.
- W2123951330 cites W2150046218 @default.
- W2123951330 cites W2153269422 @default.
- W2123951330 cites W2156813826 @default.
- W2123951330 cites W2158944306 @default.
- W2123951330 cites W2162627097 @default.
- W2123951330 cites W2168526937 @default.
- W2123951330 cites W2169060472 @default.
- W2123951330 cites W2171753300 @default.
- W2123951330 cites W2175479903 @default.
- W2123951330 cites W2228608559 @default.
- W2123951330 cites W2331730675 @default.
- W2123951330 cites W4251266101 @default.
- W2123951330 doi "https://doi.org/10.1152/ajpregu.00468.2009" @default.
- W2123951330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867512" @default.
- W2123951330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20147607" @default.
- W2123951330 hasPublicationYear "2010" @default.
- W2123951330 type Work @default.
- W2123951330 sameAs 2123951330 @default.
- W2123951330 citedByCount "44" @default.
- W2123951330 countsByYear W21239513302012 @default.
- W2123951330 countsByYear W21239513302013 @default.
- W2123951330 countsByYear W21239513302014 @default.
- W2123951330 countsByYear W21239513302015 @default.
- W2123951330 countsByYear W21239513302017 @default.
- W2123951330 countsByYear W21239513302018 @default.
- W2123951330 countsByYear W21239513302019 @default.
- W2123951330 countsByYear W21239513302020 @default.
- W2123951330 countsByYear W21239513302021 @default.
- W2123951330 countsByYear W21239513302022 @default.
- W2123951330 crossrefType "journal-article" @default.
- W2123951330 hasAuthorship W2123951330A5010282554 @default.
- W2123951330 hasAuthorship W2123951330A5034829692 @default.
- W2123951330 hasAuthorship W2123951330A5035450241 @default.
- W2123951330 hasAuthorship W2123951330A5056635157 @default.
- W2123951330 hasAuthorship W2123951330A5073614725 @default.
- W2123951330 hasAuthorship W2123951330A5081546127 @default.
- W2123951330 hasAuthorship W2123951330A5090551785 @default.
- W2123951330 hasBestOaLocation W21239513302 @default.
- W2123951330 hasConcept C126322002 @default.
- W2123951330 hasConcept C134018914 @default.
- W2123951330 hasConcept C185592680 @default.
- W2123951330 hasConcept C2776151105 @default.
- W2123951330 hasConcept C2776970464 @default.
- W2123951330 hasConcept C2777180221 @default.
- W2123951330 hasConcept C2777391703 @default.
- W2123951330 hasConcept C2778062710 @default.
- W2123951330 hasConcept C2778163477 @default.
- W2123951330 hasConcept C2778913445 @default.
- W2123951330 hasConcept C2779306644 @default.
- W2123951330 hasConcept C55493867 @default.
- W2123951330 hasConcept C555293320 @default.
- W2123951330 hasConcept C71924100 @default.