Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123957334> ?p ?o ?g. }
- W2123957334 endingPage "941" @default.
- W2123957334 startingPage "931" @default.
- W2123957334 abstract "Resistin and resistin-like molecule (RELM)β comprise a novel class of cysteine-rich proteins secreted into the circulation implicated in hepatic insulin resistance and inflammation. RELMβ is specifically produced by intestinal goblet cells but regulation of its expression and much of its local function are not elucidated. RELMβ has been suggested to regulate colonic inflammation susceptibility, which is dependent on the mucosal barrier integrity. In this work we explored the physiopathological role of RELMβ in the colon. Among agents tested, carbachol and gastrin were strong inhibitors of RELMβ mRNA accumulation. We examined the effect of recombinant RELMβ on mucin secretion by human mucus-secreting HT29-Cl.16E cells in culture and by mouse colonic goblet cells in vivo. RELMβ upregulated MUC2 and M1/MUC5AC gene expression in HT29-Cl.16E cells. RELMβ enhanced M1/MUC5AC secretion by human colonic HT29-Cl.16E cells and MUC2 secretion by murine intestinal goblet cells. RELMβ exerted its action exclusively on the apical side of HT29-Cl.16E cells, in agreement with its luminal mucosecretagogue effect in mice. Its action required calcium, protein kinase C, tyrosine kinases, and extracellular-regulated protein kinase activities and was synergized by carbachol. An intracolonic RELMβ challenge was performed in the trinitrobenzene sulfonic acid (TNBS)-murine model of colitis and macroscopic and histological scores were monitored. The macroscopic and histopathological severity of TNBS-induced colitis was significantly attenuated by RELMβ pretreatment. A direct participation in maintaining the mucosal defense barrier can be ascribed to RELMβ in line with a regulatory role in intestinal inflammation." @default.
- W2123957334 created "2016-06-24" @default.
- W2123957334 creator A5007464091 @default.
- W2123957334 creator A5010941913 @default.
- W2123957334 creator A5029043487 @default.
- W2123957334 creator A5033807726 @default.
- W2123957334 creator A5036195876 @default.
- W2123957334 creator A5037628571 @default.
- W2123957334 creator A5039923310 @default.
- W2123957334 creator A5049739395 @default.
- W2123957334 creator A5066769682 @default.
- W2123957334 creator A5073322732 @default.
- W2123957334 creator A5074351912 @default.
- W2123957334 date "2008-07-01" @default.
- W2123957334 modified "2023-09-30" @default.
- W2123957334 title "Resistin-like molecule β regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice" @default.
- W2123957334 cites W1607206333 @default.
- W2123957334 cites W1648036481 @default.
- W2123957334 cites W1675830194 @default.
- W2123957334 cites W1806863962 @default.
- W2123957334 cites W1838440139 @default.
- W2123957334 cites W1963832148 @default.
- W2123957334 cites W1965830486 @default.
- W2123957334 cites W1967217097 @default.
- W2123957334 cites W1970727986 @default.
- W2123957334 cites W1980866542 @default.
- W2123957334 cites W1983514972 @default.
- W2123957334 cites W1999744765 @default.
- W2123957334 cites W2009054323 @default.
- W2123957334 cites W2010662448 @default.
- W2123957334 cites W2016537283 @default.
- W2123957334 cites W2018620221 @default.
- W2123957334 cites W2037259912 @default.
- W2123957334 cites W2042631205 @default.
- W2123957334 cites W2043620021 @default.
- W2123957334 cites W2053911884 @default.
- W2123957334 cites W2059522738 @default.
- W2123957334 cites W2061262914 @default.
- W2123957334 cites W2062079699 @default.
- W2123957334 cites W2063731747 @default.
- W2123957334 cites W2080875750 @default.
- W2123957334 cites W2085637472 @default.
- W2123957334 cites W2087379913 @default.
- W2123957334 cites W2098413748 @default.
- W2123957334 cites W2099376515 @default.
- W2123957334 cites W2100672979 @default.
- W2123957334 cites W2104552496 @default.
- W2123957334 cites W2113474033 @default.
- W2123957334 cites W2114671731 @default.
- W2123957334 cites W2116185627 @default.
- W2123957334 cites W2127102828 @default.
- W2123957334 cites W2128337755 @default.
- W2123957334 cites W2131885678 @default.
- W2123957334 cites W2133881702 @default.
- W2123957334 cites W2133931920 @default.
- W2123957334 cites W2139889887 @default.
- W2123957334 cites W2146234274 @default.
- W2123957334 cites W2146806322 @default.
- W2123957334 cites W2150240679 @default.
- W2123957334 cites W2157393124 @default.
- W2123957334 cites W2162593372 @default.
- W2123957334 cites W2164950536 @default.
- W2123957334 cites W2165708021 @default.
- W2123957334 cites W2247034861 @default.
- W2123957334 cites W4242776856 @default.
- W2123957334 cites W51899573 @default.
- W2123957334 doi "https://doi.org/10.1002/ibd.20420" @default.
- W2123957334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18300276" @default.
- W2123957334 hasPublicationYear "2008" @default.
- W2123957334 type Work @default.
- W2123957334 sameAs 2123957334 @default.
- W2123957334 citedByCount "85" @default.
- W2123957334 countsByYear W21239573342012 @default.
- W2123957334 countsByYear W21239573342013 @default.
- W2123957334 countsByYear W21239573342014 @default.
- W2123957334 countsByYear W21239573342015 @default.
- W2123957334 countsByYear W21239573342016 @default.
- W2123957334 countsByYear W21239573342017 @default.
- W2123957334 countsByYear W21239573342018 @default.
- W2123957334 countsByYear W21239573342019 @default.
- W2123957334 countsByYear W21239573342020 @default.
- W2123957334 countsByYear W21239573342021 @default.
- W2123957334 countsByYear W21239573342022 @default.
- W2123957334 countsByYear W21239573342023 @default.
- W2123957334 crossrefType "journal-article" @default.
- W2123957334 hasAuthorship W2123957334A5007464091 @default.
- W2123957334 hasAuthorship W2123957334A5010941913 @default.
- W2123957334 hasAuthorship W2123957334A5029043487 @default.
- W2123957334 hasAuthorship W2123957334A5033807726 @default.
- W2123957334 hasAuthorship W2123957334A5036195876 @default.
- W2123957334 hasAuthorship W2123957334A5037628571 @default.
- W2123957334 hasAuthorship W2123957334A5039923310 @default.
- W2123957334 hasAuthorship W2123957334A5049739395 @default.
- W2123957334 hasAuthorship W2123957334A5066769682 @default.
- W2123957334 hasAuthorship W2123957334A5073322732 @default.
- W2123957334 hasAuthorship W2123957334A5074351912 @default.
- W2123957334 hasConcept C179264091 @default.
- W2123957334 hasConcept C185592680 @default.