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• W2123959474 abstract "Our objective was to test the hypothesis that bovine growth hormone (bGH) can induce the secretion of vasodilators by the bovine mammary gland. Three adult lactating cows were surgically implanted with catheters in the left costoabdominal artery, in the left subcutaneous abdominal vein (milk vein) and in a lymph duct afferent to the left supramammary lymph node. In addition, a transit time flow probe. was implanted on the left pudic artery. Cows were injected S.C. with either saline or 25 mg of bGH according to a crossover design. Samples from arterial and venous blood and from lymph fluid were collected from 2 hours before to 16 hours after the injection. Mammary blood flow was recorded at each sampling. Injection of bGH induced a gradual increase in mammary blood flow in lactating cows while it remained constant after the saline injection. Venous concentrations of 6-keto-prostaglandin F,,, a stable metabolite of the vasodilator prostacyclinI,, werenot affected bybGHinjection. However, lymphatic concentrationsoftheprostacyclin1, metabolite increased whencows were injected with bGH. The time course of the increase in plasma IGF-I concentration was similar to that of mammary blood flow and 6keto-prostaglandin F,,. In conclusion, a local release of prostacyclin I, may be responsible for the bGH-induced increase in mammary blood flow. IGF-I might mediate this effect of bGH." @default.
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• W2123959474 date "1994-01-01" @default.
• W2123959474 modified "2023-09-28" @default.
• W2123959474 title "Bovine growth hormone and its effects on the local production of prostacyclin I 2 and mammary blood flow in dairy cows" @default.
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