FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123982764> ?p ?o ?g. }

• W2123982764 endingPage "181" @default.
• W2123982764 startingPage "141" @default.
• W2123982764 abstract "Our understanding of the pervasive involvement of small RNAs in regulating diverse biological processes has been greatly augmented by recent application of deep-sequencing technologies to small RNA across diverse eukaryotes. We review the currently known small RNA classes and place them in context of the reconstructed evolutionary history of the RNA interference (RNAi) protein machinery. This synthesis indicates that the earliest versions of eukaryotic RNAi systems likely utilized small RNA processed from three types of precursors: (1) sense–antisense transcriptional products, (2) genome-encoded, imperfectly complementary hairpin sequences, and (3) larger noncoding RNA precursor sequences. Structural dissection of PIWI proteins along with recent discovery of novel families (including Med13 of the Mediator complex) suggest that emergence of a distinct architecture with the N-terminal domains (also occurring separately fused to endoDNases in prokaryotes) formed via duplication of an ancestral unit was key to their recruitment as primary RNAi effectors and use of small RNAs of certain preferred lengths. Prokaryotic PIWI proteins are typically components of several RNA-directed DNA restriction or CRISPR/Cas systems. However, eukaryotic versions appear to have emerged from a subset that evolved RNA-directed RNAi. They were recruited alongside RNaseIII domains and RNA-dependent RNA polymerase (RdRP) domains, also from prokaryotic systems, to form the core eukaryotic RNAi system. Like certain regulatory systems, RNAi diversified into two distinct but linked arms concomitant with eukaryotic nucleocytoplasmic compartmentalization. Subsequent elaboration of RNAi proceeded via diversification of the core protein machinery through lineage-specific expansions and recruitment of new components from prokaryotes (nucleases and small RNA-modifying enzymes), allowing for diversification of associating small RNAs. WIREs RNA 2014, 5:141–182. doi: 10.1002/wrna.1210 This article is categorized under: RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution RNA Evolution and Genomics > Computational Analyses of RNA Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs" @default.
• W2123982764 created "2016-06-24" @default.
• W2123982764 creator A5004461127 @default.
• W2123982764 creator A5026932356 @default.
• W2123982764 creator A5051765798 @default.
• W2123982764 date "2013-12-05" @default.
• W2123982764 modified "2023-10-16" @default.
• W2123982764 title "New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing" @default.
• W2123982764 cites W135990887 @default.
• W2123982764 cites W140427365 @default.
• W2123982764 cites W1494293290 @default.
• W2123982764 cites W1499220571 @default.
• W2123982764 cites W156481159 @default.
• W2123982764 cites W1585970141 @default.
• W2123982764 cites W1592521963 @default.
• W2123982764 cites W1601498895 @default.
• W2123982764 cites W1642967260 @default.
• W2123982764 cites W1686333409 @default.
• W2123982764 cites W1773519674 @default.
• W2123982764 cites W182314314 @default.
• W2123982764 cites W1916169393 @default.
• W2123982764 cites W1965954466 @default.
• W2123982764 cites W1967276739 @default.
• W2123982764 cites W1968948510 @default.
• W2123982764 cites W1969003508 @default.
• W2123982764 cites W1969142635 @default.
• W2123982764 cites W1970679679 @default.
• W2123982764 cites W1971099302 @default.
• W2123982764 cites W1973181654 @default.
• W2123982764 cites W1973203220 @default.
• W2123982764 cites W1974676736 @default.
• W2123982764 cites W1975487818 @default.
• W2123982764 cites W1975763913 @default.
• W2123982764 cites W1975993845 @default.
• W2123982764 cites W1976048929 @default.
• W2123982764 cites W1976342457 @default.
• W2123982764 cites W1976828379 @default.
• W2123982764 cites W1980643159 @default.
• W2123982764 cites W1981988708 @default.
• W2123982764 cites W1982163838 @default.
• W2123982764 cites W1984301208 @default.
• W2123982764 cites W1985140771 @default.
• W2123982764 cites W1987248329 @default.
• W2123982764 cites W1987777159 @default.
• W2123982764 cites W1987956537 @default.
• W2123982764 cites W1988153625 @default.
• W2123982764 cites W1988309554 @default.
• W2123982764 cites W1991007428 @default.
• W2123982764 cites W1991435353 @default.
• W2123982764 cites W1991497402 @default.
• W2123982764 cites W1992697747 @default.
• W2123982764 cites W1993350141 @default.
• W2123982764 cites W1995048848 @default.
• W2123982764 cites W1998026805 @default.
• W2123982764 cites W1998427421 @default.
• W2123982764 cites W1999808854 @default.
• W2123982764 cites W1999828857 @default.
• W2123982764 cites W2001677411 @default.
• W2123982764 cites W2001982664 @default.
• W2123982764 cites W2003171404 @default.
• W2123982764 cites W2003199868 @default.
• W2123982764 cites W2003875234 @default.
• W2123982764 cites W2004271888 @default.
• W2123982764 cites W2004305619 @default.
• W2123982764 cites W2005625535 @default.
• W2123982764 cites W2006821612 @default.
• W2123982764 cites W2007844697 @default.
• W2123982764 cites W2008192683 @default.
• W2123982764 cites W2008255393 @default.
• W2123982764 cites W2010794863 @default.
• W2123982764 cites W2010890469 @default.
• W2123982764 cites W2013883400 @default.
• W2123982764 cites W2015311527 @default.
• W2123982764 cites W2015591844 @default.
• W2123982764 cites W2015969705 @default.
• W2123982764 cites W2016399451 @default.
• W2123982764 cites W2017014505 @default.
• W2123982764 cites W2017733353 @default.
• W2123982764 cites W2019167811 @default.
• W2123982764 cites W2019993012 @default.
• W2123982764 cites W2021599506 @default.
• W2123982764 cites W2022091835 @default.
• W2123982764 cites W2022231987 @default.
• W2123982764 cites W2022268135 @default.
• W2123982764 cites W2022294016 @default.
• W2123982764 cites W2023663826 @default.
• W2123982764 cites W2024189395 @default.
• W2123982764 cites W2024427233 @default.
• W2123982764 cites W2024829095 @default.
• W2123982764 cites W2026488707 @default.
• W2123982764 cites W2027579493 @default.
• W2123982764 cites W2028444170 @default.
• W2123982764 cites W2028558079 @default.
• W2123982764 cites W2029521343 @default.
• W2123982764 cites W2029955900 @default.
• W2123982764 cites W2030350620 @default.
• W2123982764 cites W2032501207 @default.
• W2123982764 cites W2033518550 @default.

• next