FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123990914> ?p ?o ?g. }

• W2123990914 abstract "The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). Cecal ligation and puncture (CLP) was used to induce sepsis in mice. Survival rates were monitored and plasma indices of organ function were measured. Ex vivo studies included the measurement of vascular function in thoracic aortic rings, assessment of oxidative stress/cellular injury in various organs and the measurement of mitochondrial function in isolated liver mitochondria. eNOS deficiency and aging both exacerbated the mortality of sepsis. Both eNOS-deficient and aged mice exhibited a higher degree of sepsis-associated multiple organ dysfunction syndrome (MODS), infiltration of tissues with mononuclear cells and oxidative stress. A high degree of sepsis-induced vascular oxidative damage and endothelial dysfunction (evidenced by functional assays and multiple plasma markers of endothelial dysfunction) was detected in aortae isolated from both eNOS-/- and aged mice. There was a significant worsening of sepsis-induced mitochondrial dysfunction, both in eNOS-deficient mice and in aged mice. Comparison of the surviving and non-surviving groups of animals indicated that the severity of endothelial dysfunction may be a predictor of mortality of mice subjected to CLP-induced sepsis. Based on the studies in eNOS mice, we conclude that the lack of endothelial nitric oxide production, on its own, may be sufficient to markedly exacerbate the severity of septic shock. Aging markedly worsens the degree of endothelial dysfunction in sepsis, yielding a significant worsening of the overall outcome. Thus, endothelial dysfunction may constitute an early predictor and independent contributor to sepsis-associated MODS and mortality in aged mice." @default.
• W2123990914 created "2016-06-24" @default.
• W2123990914 creator A5001389761 @default.
• W2123990914 creator A5005923687 @default.
• W2123990914 creator A5021351628 @default.
• W2123990914 creator A5028649129 @default.
• W2123990914 creator A5037483405 @default.
• W2123990914 creator A5058049602 @default.
• W2123990914 creator A5063500296 @default.
• W2123990914 creator A5074950148 @default.
• W2123990914 date "2014-09-16" @default.
• W2123990914 modified "2023-10-18" @default.
• W2123990914 title "Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture" @default.
• W2123990914 cites W1490186599 @default.
• W2123990914 cites W1550849850 @default.
• W2123990914 cites W167171351 @default.
• W2123990914 cites W1964049268 @default.
• W2123990914 cites W1964722626 @default.
• W2123990914 cites W1967039991 @default.
• W2123990914 cites W1972042561 @default.
• W2123990914 cites W1988690966 @default.
• W2123990914 cites W1989894963 @default.
• W2123990914 cites W1990826929 @default.
• W2123990914 cites W1993899027 @default.
• W2123990914 cites W2005457113 @default.
• W2123990914 cites W2008272689 @default.
• W2123990914 cites W2014933297 @default.
• W2123990914 cites W2020510475 @default.
• W2123990914 cites W2027710298 @default.
• W2123990914 cites W2028285408 @default.
• W2123990914 cites W2029058958 @default.
• W2123990914 cites W2033656398 @default.
• W2123990914 cites W2035433014 @default.
• W2123990914 cites W2043239658 @default.
• W2123990914 cites W2044163203 @default.
• W2123990914 cites W2045447924 @default.
• W2123990914 cites W2051693516 @default.
• W2123990914 cites W2052628744 @default.
• W2123990914 cites W2054916011 @default.
• W2123990914 cites W2056778604 @default.
• W2123990914 cites W2057743296 @default.
• W2123990914 cites W2068796527 @default.
• W2123990914 cites W2068997428 @default.
• W2123990914 cites W2070113229 @default.
• W2123990914 cites W2071034808 @default.
• W2123990914 cites W2080351844 @default.
• W2123990914 cites W2081992084 @default.
• W2123990914 cites W2084630350 @default.
• W2123990914 cites W2085998238 @default.
• W2123990914 cites W2087513543 @default.
• W2123990914 cites W2088319659 @default.
• W2123990914 cites W2089362132 @default.
• W2123990914 cites W2091577537 @default.
• W2123990914 cites W2091819170 @default.
• W2123990914 cites W2096261918 @default.
• W2123990914 cites W2096706830 @default.
• W2123990914 cites W2097750015 @default.
• W2123990914 cites W2103995851 @default.
• W2123990914 cites W2109115943 @default.
• W2123990914 cites W2109765271 @default.
• W2123990914 cites W2127583356 @default.
• W2123990914 cites W2129203245 @default.
• W2123990914 cites W2129610716 @default.
• W2123990914 cites W2133617398 @default.
• W2123990914 cites W2133629433 @default.
• W2123990914 cites W2133771754 @default.
• W2123990914 cites W2136956854 @default.
• W2123990914 cites W2145577370 @default.
• W2123990914 cites W2148135522 @default.
• W2123990914 cites W2148430259 @default.
• W2123990914 cites W2159922156 @default.
• W2123990914 cites W2160964884 @default.
• W2123990914 cites W2164141638 @default.
• W2123990914 cites W2165192447 @default.
• W2123990914 cites W2170389508 @default.
• W2123990914 cites W2329027350 @default.
• W2123990914 doi "https://doi.org/10.1186/s13054-014-0511-3" @default.
• W2123990914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177582" @default.
• W2123990914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25223540" @default.
• W2123990914 hasPublicationYear "2014" @default.
• W2123990914 type Work @default.
• W2123990914 sameAs 2123990914 @default.
• W2123990914 citedByCount "70" @default.
• W2123990914 countsByYear W21239909142015 @default.
• W2123990914 countsByYear W21239909142016 @default.
• W2123990914 countsByYear W21239909142017 @default.
• W2123990914 countsByYear W21239909142018 @default.
• W2123990914 countsByYear W21239909142019 @default.
• W2123990914 countsByYear W21239909142020 @default.
• W2123990914 countsByYear W21239909142021 @default.
• W2123990914 countsByYear W21239909142022 @default.
• W2123990914 countsByYear W21239909142023 @default.
• W2123990914 crossrefType "journal-article" @default.
• W2123990914 hasAuthorship W2123990914A5001389761 @default.
• W2123990914 hasAuthorship W2123990914A5005923687 @default.
• W2123990914 hasAuthorship W2123990914A5021351628 @default.
• W2123990914 hasAuthorship W2123990914A5028649129 @default.
• W2123990914 hasAuthorship W2123990914A5037483405 @default.
• W2123990914 hasAuthorship W2123990914A5058049602 @default.
• W2123990914 hasAuthorship W2123990914A5063500296 @default.

• next