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- W2123993504 abstract "Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain major causes of morbidity and mortality in critical care medicine despite advances in therapeutic modalities. ALI can be associated with sepsis, trauma, pharmaceutical or xenobiotic exposures, high oxygen therapy (hyperoxia), and mechanical ventilation. Of the small gas molecules (NO, CO, H₂S) that arise in human beings from endogenous enzymatic activities, the physiological significance of NO is well established, whereas that of CO or H₂S remains controversial. Recent studies have explored the potential efficacy of inhalation therapies using these small gas molecules in animal models of ALI. NO has vasoregulatory and redox-active properties and can function as a selective pulmonary vasodilator. Inhaled NO (iNO) has shown promise as a therapy in animal models of ALI including endotoxin challenge, ischemia/reperfusion (I/R) injury, and lung transplantation. CO, another diatomic gas, can exert cellular tissue protection through antiapoptotic, anti-inflammatory, and antiproliferative effects. CO has shown therapeutic potential in animal models of endotoxin challenge, oxidative lung injury, I/R injury, pulmonary fibrosis, ventilator-induced lung injury, and lung transplantation. H₂S, a third potential therapeutic gas, can induce hypometabolic states in mice and can confer both pro- and anti-inflammatory effects in rodent models of ALI and sepsis. Clinical studies have shown variable results for the efficacy of iNO in lung transplantation and failure for this therapy to improve mortality in ARDS patients. No clinical studies have been conducted with H₂S. The clinical efficacy of CO remains unclear and awaits further controlled clinical studies in transplantation and sepsis." @default.
- W2123993504 created "2016-06-24" @default.
- W2123993504 creator A5028298831 @default.
- W2123993504 creator A5068367251 @default.
- W2123993504 date "2010-11-01" @default.
- W2123993504 modified "2023-10-14" @default.
- W2123993504 title "Gaseous Therapeutics in Acute Lung Injury" @default.
- W2123993504 cites W1501532586 @default.
- W2123993504 cites W1550443883 @default.
- W2123993504 cites W1561810071 @default.
- W2123993504 cites W1580076592 @default.
- W2123993504 cites W1586487499 @default.
- W2123993504 cites W1600690434 @default.
- W2123993504 cites W1636028712 @default.
- W2123993504 cites W166349719 @default.
- W2123993504 cites W1764308599 @default.
- W2123993504 cites W1767482834 @default.
- W2123993504 cites W1927797304 @default.
- W2123993504 cites W1964794255 @default.
- W2123993504 cites W1966353799 @default.
- W2123993504 cites W1967824539 @default.
- W2123993504 cites W1969495917 @default.
- W2123993504 cites W1970872524 @default.
- W2123993504 cites W1971142629 @default.
- W2123993504 cites W1972526878 @default.
- W2123993504 cites W1975399391 @default.
- W2123993504 cites W1976406874 @default.
- W2123993504 cites W1976599798 @default.
- W2123993504 cites W1978098707 @default.
- W2123993504 cites W1978719611 @default.
- W2123993504 cites W1978765308 @default.
- W2123993504 cites W1980458823 @default.
- W2123993504 cites W1984448396 @default.
- W2123993504 cites W1985289402 @default.
- W2123993504 cites W1986525923 @default.
- W2123993504 cites W1987929626 @default.
- W2123993504 cites W1990399293 @default.
- W2123993504 cites W1990756467 @default.
- W2123993504 cites W1992718978 @default.
- W2123993504 cites W1993177668 @default.
- W2123993504 cites W1994561091 @default.
- W2123993504 cites W1994780702 @default.
- W2123993504 cites W1994856586 @default.
- W2123993504 cites W1997849875 @default.
- W2123993504 cites W1998774601 @default.
- W2123993504 cites W1999807578 @default.
- W2123993504 cites W2000442106 @default.
- W2123993504 cites W2001538146 @default.
- W2123993504 cites W2003248266 @default.
- W2123993504 cites W2004763695 @default.
- W2123993504 cites W2005904261 @default.
- W2123993504 cites W2010914459 @default.
- W2123993504 cites W2015407072 @default.
- W2123993504 cites W2016285616 @default.
- W2123993504 cites W2018056489 @default.
- W2123993504 cites W2019089352 @default.
- W2123993504 cites W2019385568 @default.
- W2123993504 cites W2019814232 @default.
- W2123993504 cites W2020770681 @default.
- W2123993504 cites W2020941408 @default.
- W2123993504 cites W2021244295 @default.
- W2123993504 cites W2021637981 @default.
- W2123993504 cites W2022476666 @default.
- W2123993504 cites W2022989979 @default.
- W2123993504 cites W2024298163 @default.
- W2123993504 cites W2026338542 @default.
- W2123993504 cites W2027413649 @default.
- W2123993504 cites W2028516053 @default.
- W2123993504 cites W2028569503 @default.
- W2123993504 cites W2028606217 @default.
- W2123993504 cites W2028778467 @default.
- W2123993504 cites W2030188224 @default.
- W2123993504 cites W2030238021 @default.
- W2123993504 cites W2030310318 @default.
- W2123993504 cites W2031212351 @default.
- W2123993504 cites W2033117610 @default.
- W2123993504 cites W2034946903 @default.
- W2123993504 cites W2039912038 @default.
- W2123993504 cites W2040041910 @default.
- W2123993504 cites W2040378598 @default.
- W2123993504 cites W2040755930 @default.
- W2123993504 cites W2041075406 @default.
- W2123993504 cites W2041553103 @default.
- W2123993504 cites W2042297383 @default.
- W2123993504 cites W2043720899 @default.
- W2123993504 cites W2044953143 @default.
- W2123993504 cites W2045123815 @default.
- W2123993504 cites W2045727091 @default.
- W2123993504 cites W2046335607 @default.
- W2123993504 cites W2046485211 @default.
- W2123993504 cites W2047077257 @default.
- W2123993504 cites W2049504582 @default.
- W2123993504 cites W2050086011 @default.
- W2123993504 cites W2054064167 @default.
- W2123993504 cites W2055747781 @default.
- W2123993504 cites W2055935493 @default.
- W2123993504 cites W2057527796 @default.
- W2123993504 cites W2058982862 @default.