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• W2124003091 abstract "Colorectal cancer (CRC) is one of the leading causes of mortality worldwide. DNA methylation is an important epigenetic modification for CRC. Although currently a number of studies about DNA methylation of protein coding genes have been carried out, only a few are about the methylation of genes encoding the long noncoding RNAs (lncRNAs). In this study, we identified 761 lncRNA genes with DNA hypermethylation in CRC using a free MethylCap-seq dataset. Integration of lncRNA expression and methylation datasets showed that the expression of lncRNAs is negatively correlated with DNA methylation (p<0.01). Co-methylation network was also constructed to annotate the functions of unknown lncRNAs. Our results showed that a total of 364 lncRNAs were annotated with at least one GO biological process term. The current data-mining work is likely to provide informative clues for biological researchers to further understand the role of lncRNAs in the development of CRC." @default.
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• W2124003091 date "2015-11-01" @default.
• W2124003091 modified "2023-09-23" @default.
• W2124003091 title "Identification and functional annotation of lncRNA genes with hypermethylation in colorectal cancer" @default.
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• W2124003091 doi "https://doi.org/10.1016/j.gene.2015.07.028" @default.
• W2124003091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26172871" @default.
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