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• W2124007679 abstract "Abstract Pathogen‐mediated selection is thought to maintain the extreme diversity in the major histocompatibility complex ( MHC ) genes, operating through the heterozygote advantage, rare‐allele advantage and fluctuating selection mechanisms. Heterozygote advantage (i.e. recognizing and binding a wider range of antigens than homozygotes) is expected to be more detectable when multiple pathogens are considered simultaneously. Here, we test whether MHC diversity in a wild population of European badgers ( M eles meles ) is driven by pathogen‐mediated selection. We examined individual prevalence (infected or not), infection intensity and co‐infection of 13 pathogens from a range of taxa and examined their relationships with MHC class I and class II variability. This population has a variable, but relatively low, number of MHC alleles and is infected by a variety of naturally occurring pathogens, making it very suitable for the investigation of MHC –pathogen relationships. We found associations between pathogen infections and specific MHC haplotypes and alleles. Co‐infection status was not correlated with MHC heterozygosity, but there was evidence of heterozygote advantage against individual pathogen infections. This suggests that rare‐allele advantages and/or fluctuating selection, and heterozygote advantage are probably the selective forces shaping MHC diversity in this species. We show stronger evidence for MHC associations with infection intensity than for prevalence and conclude that examining both pathogen prevalence and infection intensity is important. Moreover, examination of a large number and diversity of pathogens, and both MHC class I and II genes (which have different functions), provide an improved understanding of the mechanisms driving MHC diversity." @default.
• W2124007679 created "2016-06-24" @default.
• W2124007679 creator A5027457367 @default.
• W2124007679 creator A5036290149 @default.
• W2124007679 creator A5039017008 @default.
• W2124007679 creator A5040670921 @default.
• W2124007679 creator A5053755354 @default.
• W2124007679 creator A5062119084 @default.
• W2124007679 date "2014-10-01" @default.
• W2124007679 modified "2023-10-04" @default.
• W2124007679 title "Pathogen burden, co-infection and major histocompatibility complex variability in the European badger (<i>Meles meles</i>)" @default.
• W2124007679 cites W1518897246 @default.
• W2124007679 cites W1540952648 @default.
• W2124007679 cites W1542811994 @default.
• W2124007679 cites W1544696596 @default.
• W2124007679 cites W1583105087 @default.
• W2124007679 cites W1652383174 @default.
• W2124007679 cites W1898737497 @default.
• W2124007679 cites W1929921649 @default.
• W2124007679 cites W1951053887 @default.
• W2124007679 cites W1964099024 @default.
• W2124007679 cites W1968356813 @default.
• W2124007679 cites W1969583036 @default.
• W2124007679 cites W1970068443 @default.
• W2124007679 cites W1974466317 @default.
• W2124007679 cites W1975101865 @default.
• W2124007679 cites W1976881321 @default.
• W2124007679 cites W1982873334 @default.
• W2124007679 cites W1982903430 @default.
• W2124007679 cites W1984819976 @default.
• W2124007679 cites W1984997549 @default.
• W2124007679 cites W1990036222 @default.
• W2124007679 cites W1995453338 @default.
• W2124007679 cites W2001497625 @default.
• W2124007679 cites W2013473463 @default.
• W2124007679 cites W2022454563 @default.
• W2124007679 cites W2023301397 @default.
• W2124007679 cites W2024279969 @default.
• W2124007679 cites W2025986883 @default.
• W2124007679 cites W2032301833 @default.
• W2124007679 cites W2033019501 @default.
• W2124007679 cites W2041453228 @default.
• W2124007679 cites W2043637778 @default.
• W2124007679 cites W2049656373 @default.
• W2124007679 cites W2050703672 @default.
• W2124007679 cites W2051184702 @default.
• W2124007679 cites W2053686485 @default.
• W2124007679 cites W2055399969 @default.
• W2124007679 cites W2056384440 @default.
• W2124007679 cites W2063838707 @default.
• W2124007679 cites W2064342351 @default.
• W2124007679 cites W2064773757 @default.
• W2124007679 cites W2068020601 @default.
• W2124007679 cites W2071263235 @default.
• W2124007679 cites W2074097475 @default.
• W2124007679 cites W2075570353 @default.
• W2124007679 cites W2081750855 @default.
• W2124007679 cites W2086013059 @default.
• W2124007679 cites W2086864147 @default.
• W2124007679 cites W2087124265 @default.
• W2124007679 cites W2089145757 @default.
• W2124007679 cites W2090320337 @default.
• W2124007679 cites W2096650374 @default.
• W2124007679 cites W2100804787 @default.
• W2124007679 cites W2101449479 @default.
• W2124007679 cites W2106285437 @default.
• W2124007679 cites W2106459047 @default.
• W2124007679 cites W2108019917 @default.
• W2124007679 cites W2108134955 @default.
• W2124007679 cites W2108328346 @default.
• W2124007679 cites W2111491914 @default.
• W2124007679 cites W2116492562 @default.
• W2124007679 cites W2117941191 @default.
• W2124007679 cites W2118494668 @default.
• W2124007679 cites W2127512832 @default.
• W2124007679 cites W2129979981 @default.
• W2124007679 cites W2130746596 @default.
• W2124007679 cites W2130783116 @default.
• W2124007679 cites W2131098197 @default.
• W2124007679 cites W2131842864 @default.
• W2124007679 cites W2132192460 @default.
• W2124007679 cites W2135393303 @default.
• W2124007679 cites W2139214408 @default.
• W2124007679 cites W2141629782 @default.
• W2124007679 cites W2141917866 @default.
• W2124007679 cites W2145104130 @default.
• W2124007679 cites W2145454207 @default.
• W2124007679 cites W2149540935 @default.
• W2124007679 cites W2153918116 @default.
• W2124007679 cites W2157285699 @default.
• W2124007679 cites W2157358066 @default.
• W2124007679 cites W2157764447 @default.
• W2124007679 cites W2160297684 @default.
• W2124007679 cites W2162895135 @default.
• W2124007679 cites W2166029762 @default.
• W2124007679 cites W2166253106 @default.
• W2124007679 cites W2169029547 @default.
• W2124007679 cites W2169220682 @default.

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