FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124013690> ?p ?o ?g. }

• W2124013690 endingPage "1026" @default.
• W2124013690 startingPage "1019" @default.
• W2124013690 abstract "We identified a novel paromomycin resistance-associated mutation in rpsL, caused by the insertion of a glycine residue at position 92, in Streptomyces coelicolor ribosomal protein S12. This insertion mutation (GI92) resulted in a 20-fold increase in the paromomycin resistance level. In combination with another S12 mutation, K88E, the GI92 mutation markedly enhanced the production of the blue-colored polyketide antibiotic actinorhodin and the red-colored antibiotic undecylprodigiosin. The gene replacement experiments demonstrated that the K88E-GI92 double mutation in the rpsL gene was responsible for the marked enhancement of antibiotic production observed. Ribosomes with the K88E-GI92 double mutation were characterized by error restrictiveness (i.e., hyperaccuracy). Using a cell-free translation system, we found that mutant ribosomes harboring the K88E-GI92 double mutation but not ribosomes harboring the GI92 mutation alone displayed sixfold greater translation activity relative to that of the wild-type ribosomes at late growth phase. This resulted in the overproduction of actinorhodin, caused by the transcriptional activation of the pathway-specific regulatory gene actII-orf4, possibly due to the increased translation of transcripts encoding activators of actII-orf4. The mutant with the K88E-GI92 double mutation accumulated a high level of ribosome recycling factor at late stationary phase, underlying the high level of protein synthesis activity observed." @default.
• W2124013690 created "2016-06-24" @default.
• W2124013690 creator A5032688795 @default.
• W2124013690 creator A5054271905 @default.
• W2124013690 creator A5078174254 @default.
• W2124013690 creator A5088076962 @default.
• W2124013690 date "2009-03-01" @default.
• W2124013690 modified "2023-10-16" @default.
• W2124013690 title "A Novel Insertion Mutation in <i>Streptomyces coelicolor</i> Ribosomal S12 Protein Results in Paromomycin Resistance and Antibiotic Overproduction" @default.
• W2124013690 cites W1491607388 @default.
• W2124013690 cites W1495297272 @default.
• W2124013690 cites W1533402230 @default.
• W2124013690 cites W1546796120 @default.
• W2124013690 cites W1963801003 @default.
• W2124013690 cites W1965252702 @default.
• W2124013690 cites W1967743590 @default.
• W2124013690 cites W1976859303 @default.
• W2124013690 cites W1980231232 @default.
• W2124013690 cites W1985851916 @default.
• W2124013690 cites W1990868144 @default.
• W2124013690 cites W1999789124 @default.
• W2124013690 cites W2001660333 @default.
• W2124013690 cites W2015611931 @default.
• W2124013690 cites W2015658684 @default.
• W2124013690 cites W2015697666 @default.
• W2124013690 cites W2018110831 @default.
• W2124013690 cites W2026666552 @default.
• W2124013690 cites W2040883548 @default.
• W2124013690 cites W2057364144 @default.
• W2124013690 cites W2063111116 @default.
• W2124013690 cites W2097493414 @default.
• W2124013690 cites W2097886242 @default.
• W2124013690 cites W2108435028 @default.
• W2124013690 cites W2108466961 @default.
• W2124013690 cites W2109566996 @default.
• W2124013690 cites W2111203830 @default.
• W2124013690 cites W2113761741 @default.
• W2124013690 cites W2114769401 @default.
• W2124013690 cites W2119770717 @default.
• W2124013690 cites W2121753582 @default.
• W2124013690 cites W2122199512 @default.
• W2124013690 cites W2126780661 @default.
• W2124013690 cites W2153388756 @default.
• W2124013690 cites W2166483857 @default.
• W2124013690 cites W2168280380 @default.
• W2124013690 cites W2170243611 @default.
• W2124013690 cites W4211133328 @default.
• W2124013690 cites W4255521514 @default.
• W2124013690 doi "https://doi.org/10.1128/aac.00388-08" @default.
• W2124013690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650515" @default.
• W2124013690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19104019" @default.
• W2124013690 hasPublicationYear "2009" @default.
• W2124013690 type Work @default.
• W2124013690 sameAs 2124013690 @default.
• W2124013690 citedByCount "27" @default.
• W2124013690 countsByYear W21240136902012 @default.
• W2124013690 countsByYear W21240136902013 @default.
• W2124013690 countsByYear W21240136902015 @default.
• W2124013690 countsByYear W21240136902016 @default.
• W2124013690 countsByYear W21240136902017 @default.
• W2124013690 countsByYear W21240136902018 @default.
• W2124013690 countsByYear W21240136902019 @default.
• W2124013690 countsByYear W21240136902020 @default.
• W2124013690 countsByYear W21240136902021 @default.
• W2124013690 countsByYear W21240136902022 @default.
• W2124013690 crossrefType "journal-article" @default.
• W2124013690 hasAuthorship W2124013690A5032688795 @default.
• W2124013690 hasAuthorship W2124013690A5054271905 @default.
• W2124013690 hasAuthorship W2124013690A5078174254 @default.
• W2124013690 hasAuthorship W2124013690A5088076962 @default.
• W2124013690 hasBestOaLocation W21240136902 @default.
• W2124013690 hasConcept C104317684 @default.
• W2124013690 hasConcept C105580179 @default.
• W2124013690 hasConcept C124420848 @default.
• W2124013690 hasConcept C143065580 @default.
• W2124013690 hasConcept C149364088 @default.
• W2124013690 hasConcept C2776114741 @default.
• W2124013690 hasConcept C2776668381 @default.
• W2124013690 hasConcept C2777787772 @default.
• W2124013690 hasConcept C2780681812 @default.
• W2124013690 hasConcept C3675279 @default.
• W2124013690 hasConcept C38062823 @default.
• W2124013690 hasConcept C40749294 @default.
• W2124013690 hasConcept C501593827 @default.
• W2124013690 hasConcept C501734568 @default.
• W2124013690 hasConcept C54355233 @default.
• W2124013690 hasConcept C67705224 @default.
• W2124013690 hasConcept C86803240 @default.
• W2124013690 hasConcept C88478588 @default.
• W2124013690 hasConceptScore W2124013690C104317684 @default.
• W2124013690 hasConceptScore W2124013690C105580179 @default.
• W2124013690 hasConceptScore W2124013690C124420848 @default.
• W2124013690 hasConceptScore W2124013690C143065580 @default.
• W2124013690 hasConceptScore W2124013690C149364088 @default.
• W2124013690 hasConceptScore W2124013690C2776114741 @default.
• W2124013690 hasConceptScore W2124013690C2776668381 @default.
• W2124013690 hasConceptScore W2124013690C2777787772 @default.
• W2124013690 hasConceptScore W2124013690C2780681812 @default.

• next