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• W2124015317 abstract "Drebrin is a mammalian neuronal protein that binds to and organizes filamentous actin (F-actin) in dendritic spines, the receptive regions of most excitatory synapses that play a crucial role in higher brain functions. Here, the structural effects of drebrin on F-actin were examined in solution. Depolymerization and differential scanning calorimetry assays show that F-actin is stabilized by the binding of drebrin. Drebrin inhibits depolymerization mainly at the barbed end of F-actin. Full-length drebrin and its C-terminal truncated constructs were used to clarify the domain requirements for these effects. The actin binding domain of drebrin decreases the intrastrand disulfide cross-linking of Cys-41 (in the DNase I binding loop) to Cys-374 (C-terminal) but increases the interstrand disulfide cross-linking of Cys-265 (hydrophobic loop) to Cys-374 in the yeast mutants Q41C and S265C, respectively. We also demonstrate, using solution biochemistry methods and EM, the rescue of filament formation by drebrin in different cases of longitudinal interprotomer contact perturbation: the T203C/C374S yeast actin mutant and grimelysin-cleaved skeletal actin (between Gly-42 and Val-43). Additionally, we show that drebrin rescues the polymerization of V266G/L267G, a hydrophobic loop yeast actin mutant with an impaired lateral interface formation between the two filament strands. Overall, our data suggest that drebrin stabilizes actin filaments through its effect on their interstrand and intrastrand contacts." @default.
• W2124015317 created "2016-06-24" @default.
• W2124015317 creator A5038398169 @default.
• W2124015317 creator A5063449870 @default.
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• W2124015317 date "2013-07-01" @default.
• W2124015317 modified "2023-10-06" @default.
• W2124015317 title "Drebrin-induced Stabilization of Actin Filaments" @default.
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• W2124015317 doi "https://doi.org/10.1074/jbc.m113.472647" @default.
• W2124015317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3707693" @default.
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• W2124015317 hasPublicationYear "2013" @default.
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