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• W2124018509 abstract "ABSTRACT Expression of the Bacillus subtilis tryptophan biosynthetic genes ( trpEDCFBA and pabA [ trpG ]) is regulated in response to tryptophan by TRAP, the trp RNA-binding attenuation protein. TRAP-mediated regulation of the tryptophan biosynthetic genes includes a transcription attenuation and two distinct translation control mechanisms. TRAP also regulates translation of trpP ( yhaG ), a single-gene operon that encodes a putative tryptophan transporter. Its translation initiation region contains triplet repeats typical of TRAP-regulated mRNAs. We found that regulation of trpP and pabA is unaltered in a rho mutant strain. Results from filter binding and gel mobility shift assays demonstrated that TRAP binds specifically to a segment of the trpP transcript that includes the untranslated leader and translation initiation region. While the affinities of TRAP for the trpP and pabA transcripts are similar, TRAP-mediated translation control of trpP is much more extensive than for pabA . RNA footprinting revealed that the trpP TRAP binding site consists of nine triplet repeats (five GAG, three UAG, and one AAG) that surround and overlap the trpP Shine-Dalgarno (S-D) sequence and translation start codon. Results from toeprint and RNA-directed cell-free translation experiments indicated that tryptophan-activated TRAP inhibits TrpP synthesis by preventing binding of a 30S ribosomal subunit. Taken together, our results establish that TRAP regulates translation of trpP by blocking ribosome binding. Thus, TRAP coordinately regulates tryptophan synthesis and transport by three distinct mechanisms: attenuation transcription of the trpEDCFBA operon, promoting formation of the trpE S-D blocking hairpin, and blocking ribosome binding to the pabA and trpP transcripts." @default.
• W2124018509 created "2016-06-24" @default.
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• W2124018509 date "2004-01-15" @default.
• W2124018509 modified "2023-10-11" @default.
• W2124018509 title "The <i>trp</i> RNA-Binding Attenuation Protein of <i>Bacillus subtilis</i> Regulates Translation of the Tryptophan Transport Gene <i>trpP</i> ( <i>yhaG</i> ) by Blocking Ribosome Binding" @default.
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• W2124018509 doi "https://doi.org/10.1128/jb.186.2.278-286.2004" @default.
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