FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124037996> ?p ?o ?g. }

• W2124037996 endingPage "1915" @default.
• W2124037996 startingPage "1907" @default.
• W2124037996 abstract "Previously, we established that suppressing the constitutive activation of NF-kappaB in in vitro matured human macrophages resulted in apoptosis initiated by a decrease of the Bcl-2 family member, A1, and the loss of mitochondrial transmembrane potential (Deltapsi(m)). This study was performed to characterize the mechanism of TNF-alpha-induced apoptosis in macrophages following the inhibition of NF-kappaB. The addition of TNF-alpha markedly enhanced the loss of Deltapsi(m) and the induction of apoptotic cell death. Although caspase 8 was activated and contributed to DNA fragmentation, it was not necessary for the TNF-alpha-induced loss of Deltapsi(m). The inhibition of NF-kappaB alone resulted in the release of cytochrome c from the mitochondria, while both cytochrome c and second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI were released following the addition of TNF-alpha. Furthermore, c-Jun N-terminal kinase activation, which was sustained following treatment with TNF-alpha when NF-kappaB was inhibited, contributed to DNA fragmentation. These observations demonstrate that cytochrome c and second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI may be differentially released from the mitochondria, and that the sustained activation of c-Jun N-terminal kinase modulated the DNA fragmentation independent of the loss of Deltapsi(m)." @default.
• W2124037996 created "2016-06-24" @default.
• W2124037996 creator A5003125279 @default.
• W2124037996 creator A5010355987 @default.
• W2124037996 creator A5031743147 @default.
• W2124037996 creator A5062155931 @default.
• W2124037996 creator A5066195792 @default.
• W2124037996 creator A5079417201 @default.
• W2124037996 creator A5085079864 @default.
• W2124037996 date "2004-01-20" @default.
• W2124037996 modified "2023-10-17" @default.
• W2124037996 title "TNF-α-Induced Apoptosis of Macrophages Following Inhibition of NF-κB: A Central Role for Disruption of Mitochondria" @default.
• W2124037996 cites W107210068 @default.
• W2124037996 cites W1523595999 @default.
• W2124037996 cites W1563090311 @default.
• W2124037996 cites W1593219141 @default.
• W2124037996 cites W1618299283 @default.
• W2124037996 cites W178619716 @default.
• W2124037996 cites W1888783223 @default.
• W2124037996 cites W1963904830 @default.
• W2124037996 cites W1964830665 @default.
• W2124037996 cites W1973109581 @default.
• W2124037996 cites W1975773646 @default.
• W2124037996 cites W1976385326 @default.
• W2124037996 cites W1983398917 @default.
• W2124037996 cites W1984547206 @default.
• W2124037996 cites W1985628988 @default.
• W2124037996 cites W1988353980 @default.
• W2124037996 cites W1988728998 @default.
• W2124037996 cites W1991735848 @default.
• W2124037996 cites W1991868611 @default.
• W2124037996 cites W1995259476 @default.
• W2124037996 cites W2000225649 @default.
• W2124037996 cites W2000529918 @default.
• W2124037996 cites W2000601138 @default.
• W2124037996 cites W2012173926 @default.
• W2124037996 cites W2016538746 @default.
• W2124037996 cites W2023073081 @default.
• W2124037996 cites W2032417513 @default.
• W2124037996 cites W2032514624 @default.
• W2124037996 cites W2036937264 @default.
• W2124037996 cites W2039597975 @default.
• W2124037996 cites W2042274679 @default.
• W2124037996 cites W2042832398 @default.
• W2124037996 cites W2043049816 @default.
• W2124037996 cites W2051258629 @default.
• W2124037996 cites W2053372168 @default.
• W2124037996 cites W2057235597 @default.
• W2124037996 cites W2059995799 @default.
• W2124037996 cites W2061497413 @default.
• W2124037996 cites W2062853648 @default.
• W2124037996 cites W2065257477 @default.
• W2124037996 cites W2069508460 @default.
• W2124037996 cites W2070055534 @default.
• W2124037996 cites W2075477970 @default.
• W2124037996 cites W2094334993 @default.
• W2124037996 cites W2096747831 @default.
• W2124037996 cites W2097672870 @default.
• W2124037996 cites W2105253445 @default.
• W2124037996 cites W2107588151 @default.
• W2124037996 cites W2114133973 @default.
• W2124037996 cites W2123513769 @default.
• W2124037996 cites W2125715557 @default.
• W2124037996 cites W2132877097 @default.
• W2124037996 cites W2133984207 @default.
• W2124037996 cites W2134497025 @default.
• W2124037996 cites W2138624698 @default.
• W2124037996 cites W2140556587 @default.
• W2124037996 cites W2148771202 @default.
• W2124037996 cites W2161996856 @default.
• W2124037996 cites W2162748264 @default.
• W2124037996 cites W2163034757 @default.
• W2124037996 cites W2165546509 @default.
• W2124037996 cites W2169724245 @default.
• W2124037996 cites W2171317213 @default.
• W2124037996 cites W2171365668 @default.
• W2124037996 cites W2185702474 @default.
• W2124037996 cites W2340645383 @default.
• W2124037996 cites W2470223656 @default.
• W2124037996 cites W4249908443 @default.
• W2124037996 cites W4253071419 @default.
• W2124037996 doi "https://doi.org/10.4049/jimmunol.172.3.1907" @default.
• W2124037996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14734776" @default.
• W2124037996 hasPublicationYear "2004" @default.
• W2124037996 type Work @default.
• W2124037996 sameAs 2124037996 @default.
• W2124037996 citedByCount "77" @default.
• W2124037996 countsByYear W21240379962012 @default.
• W2124037996 countsByYear W21240379962013 @default.
• W2124037996 countsByYear W21240379962014 @default.
• W2124037996 countsByYear W21240379962016 @default.
• W2124037996 countsByYear W21240379962017 @default.
• W2124037996 countsByYear W21240379962018 @default.
• W2124037996 countsByYear W21240379962019 @default.
• W2124037996 countsByYear W21240379962020 @default.
• W2124037996 countsByYear W21240379962021 @default.
• W2124037996 countsByYear W21240379962022 @default.
• W2124037996 countsByYear W21240379962023 @default.

• next