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• W2124047303 abstract "This paper presents basic data on organophosphonate (OP) mechanisms of action, especially by toxicokinetic/toxicodynamic (TK/TD) process correlations. It is generally accepted that at least during onset of OP biological systems interaction, blood and tissue cholinesterase's inhibition represents OP exposure marker and initiating mechanisms for toxicodynamic effects, characteristic for cholinergic crisis. OP penetrability of various biological barriers conditioning TK characteristics are determined by a series of physico-chemical properties. Non-cholinergic effects, direct interactions with cellular structures and subsequent effects (excitotoxicity) triggered by cholinergic crisis are also briefly presented. Opposed to these OP TK/TD characteristics, the authors analysed the pharmacokinetic/pharmacodynamic (PK/PD) characteristics and their correlations for oximes, as basic OP antidotes, besides atropine and anticonvulsants. Phosphorilated cholinesterasis reactivators are mono or bispyridinium derivatives with quaternary ammonium atoms, high water solubility, ionized at physiological pH, distribution in extra-cellular space, very low digestive absorption and blood-brain barrier (BBB) penetrability. OP nerve gas acute toxicity is correlated with anti-acetylcholinesterase (AChE) activity and partition coefficient. The toxicity rank seems to be determined by lipophilicity, besides their specific AChE inhibitory property. It has the effect that acute toxicity is the resultant of a TD process closely linked and dependent in vivo upon molecular descriptors determinant for the TK process. For cholinesterasis reactivators, molecular and PK characteristics limit their effects, especially to the peripheral level. The absent or much reduced BBB penetrability allowed some researchers to suggest that reactivators' penetration and presence at central level are not necessary. The study of PK/PD correlations, molecular descriptors and biological membrane permeability of oximes can better define their antidotal effects mechanisms and, maybe, open a new perspective for field development." @default.
• W2124047303 created "2016-06-24" @default.
• W2124047303 creator A5007958280 @default.
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• W2124047303 date "2010-02-01" @default.
• W2124047303 modified "2023-10-18" @default.
• W2124047303 title "The Toxicokinetics and Toxicodynamics of Organophosphonates<i>versus</i>the Pharmacokinetics and Pharmacodynamics of Oxime Antidotes: Biological Consequences" @default.
• W2124047303 cites W1489003835 @default.
• W2124047303 cites W1498305210 @default.
• W2124047303 cites W1516154703 @default.
• W2124047303 cites W1541490300 @default.
• W2124047303 cites W1575460073 @default.
• W2124047303 cites W1589775017 @default.
• W2124047303 cites W1965224657 @default.
• W2124047303 cites W1967007780 @default.
• W2124047303 cites W1967198620 @default.
• W2124047303 cites W1969047674 @default.
• W2124047303 cites W1970125408 @default.
• W2124047303 cites W1971253356 @default.
• W2124047303 cites W1971513938 @default.
• W2124047303 cites W1982740778 @default.
• W2124047303 cites W1988691170 @default.
• W2124047303 cites W1990504501 @default.
• W2124047303 cites W1992215820 @default.
• W2124047303 cites W1993138129 @default.
• W2124047303 cites W1995525413 @default.
• W2124047303 cites W1996768706 @default.
• W2124047303 cites W1997164821 @default.
• W2124047303 cites W2002797282 @default.
• W2124047303 cites W2006312252 @default.
• W2124047303 cites W2006722061 @default.
• W2124047303 cites W2008945669 @default.
• W2124047303 cites W2009264133 @default.
• W2124047303 cites W2009638691 @default.
• W2124047303 cites W2009979602 @default.
• W2124047303 cites W2013643015 @default.
• W2124047303 cites W2014699632 @default.
• W2124047303 cites W2015891310 @default.
• W2124047303 cites W2018078827 @default.
• W2124047303 cites W2020190657 @default.
• W2124047303 cites W2021099633 @default.
• W2124047303 cites W2024662280 @default.
• W2124047303 cites W2028628001 @default.
• W2124047303 cites W2028696484 @default.
• W2124047303 cites W2038197916 @default.
• W2124047303 cites W2038600241 @default.
• W2124047303 cites W2039092171 @default.
• W2124047303 cites W2055767424 @default.
• W2124047303 cites W2057244433 @default.
• W2124047303 cites W2059867491 @default.
• W2124047303 cites W2060992818 @default.
• W2124047303 cites W2065267580 @default.
• W2124047303 cites W2065693676 @default.
• W2124047303 cites W2070659151 @default.
• W2124047303 cites W2072115100 @default.
• W2124047303 cites W2078007218 @default.
• W2124047303 cites W2080559472 @default.
• W2124047303 cites W2082085879 @default.
• W2124047303 cites W2085006365 @default.
• W2124047303 cites W2095384268 @default.
• W2124047303 cites W2095703183 @default.
• W2124047303 cites W2102567650 @default.
• W2124047303 cites W2105691682 @default.
• W2124047303 cites W2106168273 @default.
• W2124047303 cites W2109385147 @default.
• W2124047303 cites W2117631804 @default.
• W2124047303 cites W2120051546 @default.
• W2124047303 cites W2120765078 @default.
• W2124047303 cites W2126826655 @default.
• W2124047303 cites W2134163530 @default.
• W2124047303 cites W2135732933 @default.
• W2124047303 cites W2137210137 @default.
• W2124047303 cites W2140514241 @default.
• W2124047303 cites W2163762710 @default.
• W2124047303 cites W2167181480 @default.
• W2124047303 cites W2169836277 @default.
• W2124047303 cites W2227604331 @default.
• W2124047303 cites W22528395 @default.
• W2124047303 cites W3175318380 @default.
• W2124047303 cites W4232706823 @default.
• W2124047303 cites W4244135429 @default.
• W2124047303 cites W4366345816 @default.
• W2124047303 doi "https://doi.org/10.1111/j.1742-7843.2009.00486.x" @default.
• W2124047303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19961476" @default.
• W2124047303 hasPublicationYear "2010" @default.
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