FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124080275> ?p ?o ?g. }

• W2124080275 endingPage "744" @default.
• W2124080275 startingPage "729" @default.
• W2124080275 abstract "Abstract NADPH oxidase (NOX)-derived reactive oxygen species (ROS) act as signaling determinants that induce different cellular processes. To characterize NOX function during fungal development, we utilized the genetically tractable ascomycete Sordaria macrospora. Genome sequencing of a sterile mutant led us to identify the NADPH oxidase encoding nox1 as a gene required for fruiting body formation, regular hyphal growth, and hyphal fusion. These phenotypes are shared by ∆nor1, lacking the NOX regulator NOR1. Further phenotypic analyses revealed a high correlation between increased ROS production and hyphal fusion deficiencies in ∆nox1 and other sterile mutants. A genome-wide transcriptional profiling analysis of mycelia and isolated protoperithecia from wild type and ∆nox1 revealed that nox1 inactivation affects the expression of genes related to cytoskeleton remodeling, hyphal fusion, metabolism, and mitochondrial respiration. Genetic analysis of ∆nox2, lacking the NADPH oxidase 2 gene, ∆nor1, and transcription factor deletion mutant ∆ste12, revealed a strict melanin-dependent ascospore germination defect, indicating a common genetic pathway for these three genes. We report that gsa3, encoding a G-protein α-subunit, and sac1, encoding cAMP-generating adenylate cyclase, act in a separate pathway during the germination process. The finding that cAMP inhibits ascospore germination in a melanin-dependent manner supports a model in which cAMP inhibits NOX2 activity, thus suggesting a link between both pathways. Our results expand the current knowledge on the role of NOX enzymes in fungal development and provide a frame to define upstream and downstream components of the NOX signaling pathways in fungi." @default.
• W2124080275 created "2016-06-24" @default.
• W2124080275 creator A5006631870 @default.
• W2124080275 creator A5021457266 @default.
• W2124080275 creator A5043066363 @default.
• W2124080275 creator A5055415104 @default.
• W2124080275 creator A5064889575 @default.
• W2124080275 creator A5074837965 @default.
• W2124080275 date "2014-03-01" @default.
• W2124080275 modified "2023-10-01" @default.
• W2124080275 title "New Insights Into the Roles of NADPH Oxidases in Sexual Development and Ascospore Germination in <i>Sordaria macrospora</i>" @default.
• W2124080275 cites W118041914 @default.
• W2124080275 cites W118787052 @default.
• W2124080275 cites W1867556649 @default.
• W2124080275 cites W1903792504 @default.
• W2124080275 cites W1917272836 @default.
• W2124080275 cites W1960938381 @default.
• W2124080275 cites W1963552086 @default.
• W2124080275 cites W1972542282 @default.
• W2124080275 cites W1977930150 @default.
• W2124080275 cites W1982411986 @default.
• W2124080275 cites W1984060790 @default.
• W2124080275 cites W1984794097 @default.
• W2124080275 cites W1985886599 @default.
• W2124080275 cites W1986212560 @default.
• W2124080275 cites W1999536834 @default.
• W2124080275 cites W2004364440 @default.
• W2124080275 cites W2005861566 @default.
• W2124080275 cites W2007497831 @default.
• W2124080275 cites W2011485738 @default.
• W2124080275 cites W2017319917 @default.
• W2124080275 cites W2037755644 @default.
• W2124080275 cites W2040609093 @default.
• W2124080275 cites W2041715628 @default.
• W2124080275 cites W2059240598 @default.
• W2124080275 cites W2072133622 @default.
• W2124080275 cites W2083704716 @default.
• W2124080275 cites W2085449098 @default.
• W2124080275 cites W2090072861 @default.
• W2124080275 cites W2091512138 @default.
• W2124080275 cites W2095972372 @default.
• W2124080275 cites W2100402653 @default.
• W2124080275 cites W2102187892 @default.
• W2124080275 cites W2102619095 @default.
• W2124080275 cites W2102909763 @default.
• W2124080275 cites W2103441770 @default.
• W2124080275 cites W2106540732 @default.
• W2124080275 cites W2108017240 @default.
• W2124080275 cites W2108234281 @default.
• W2124080275 cites W2121366285 @default.
• W2124080275 cites W2122341467 @default.
• W2124080275 cites W2123100463 @default.
• W2124080275 cites W2124331024 @default.
• W2124080275 cites W2124646812 @default.
• W2124080275 cites W2126610283 @default.
• W2124080275 cites W2127189378 @default.
• W2124080275 cites W2128540094 @default.
• W2124080275 cites W2130927298 @default.
• W2124080275 cites W2137917513 @default.
• W2124080275 cites W2140289048 @default.
• W2124080275 cites W2145029388 @default.
• W2124080275 cites W2149333591 @default.
• W2124080275 cites W2149680949 @default.
• W2124080275 cites W2150764377 @default.
• W2124080275 cites W2152239989 @default.
• W2124080275 cites W2154606961 @default.
• W2124080275 cites W2157186150 @default.
• W2124080275 cites W2158747156 @default.
• W2124080275 cites W2163289290 @default.
• W2124080275 cites W2168252436 @default.
• W2124080275 cites W2912179861 @default.
• W2124080275 cites W4319293067 @default.
• W2124080275 doi "https://doi.org/10.1534/genetics.113.159368" @default.
• W2124080275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3948803" @default.
• W2124080275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24407906" @default.
• W2124080275 hasPublicationYear "2014" @default.
• W2124080275 type Work @default.
• W2124080275 sameAs 2124080275 @default.
• W2124080275 citedByCount "80" @default.
• W2124080275 countsByYear W21240802752014 @default.
• W2124080275 countsByYear W21240802752015 @default.
• W2124080275 countsByYear W21240802752016 @default.
• W2124080275 countsByYear W21240802752017 @default.
• W2124080275 countsByYear W21240802752018 @default.
• W2124080275 countsByYear W21240802752019 @default.
• W2124080275 countsByYear W21240802752020 @default.
• W2124080275 countsByYear W21240802752021 @default.
• W2124080275 countsByYear W21240802752022 @default.
• W2124080275 countsByYear W21240802752023 @default.
• W2124080275 crossrefType "journal-article" @default.
• W2124080275 hasAuthorship W2124080275A5006631870 @default.
• W2124080275 hasAuthorship W2124080275A5021457266 @default.
• W2124080275 hasAuthorship W2124080275A5043066363 @default.
• W2124080275 hasAuthorship W2124080275A5055415104 @default.
• W2124080275 hasAuthorship W2124080275A5064889575 @default.
• W2124080275 hasAuthorship W2124080275A5074837965 @default.
• W2124080275 hasBestOaLocation W21240802751 @default.
• W2124080275 hasConcept C104317684 @default.

• next