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- W2124083737 abstract "The acute cellular electrophysiologic actions of flecainide acetate on isolated neonatal and adult canine ventricular myocardium and Purkinje fibers were evaluated with standard microelectrode techniques. Flecainide, 0.1 to 10.0 μg/ml, produced concentration-dependent decreases in action potential amplitude, overshoot, and phase O V̇max of adult ventricular myocardium and Purkinje fibers. The greatest effects were on V̇max. Neonatal action potential characteristics were affected to a lesser degree by flecainlde. Flecainide had disparate effects on myocardial and Purkinje fiber repolarization and refractoriness. In adult ventricular myocardium, action potential duration (APD) and effective refractory perlod (ERP) Increased progressively with drug concentration. APD and ERP were Increased to a leasser degree in neonatal myocardium. In adult Purkinje fibers, APD decreased progressively with increasing flecainide concentrations. ERP decreased at 0.1 and 1.0 μg/ml, but returned to control values at 10.0 μg/ml. APD and ERP of neonatal Purkinje fibers responded to a lesser degree. At faster stimulation frequencies (2 to 4 Hz), flecainide produced significant frequency-dependent decreases in V̇max in adult Purkinje fibers. Such use-dependency was not evident in neonatal fibers. These data indicate a significantly lower sensitivity of immature cardiac tissues to the electrophysiologic effects of flecainide." @default.
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- W2124083737 date "1987-01-01" @default.
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- W2124083737 title "Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers" @default.
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- W2124083737 doi "https://doi.org/10.1016/0002-8703(87)90011-1" @default.
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