FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124085063> ?p ?o ?g. }

• W2124085063 endingPage "2156" @default.
• W2124085063 startingPage "2148" @default.
• W2124085063 abstract "PpsR from the anoxygenic phototrophic bacterium Rhodobacter sphaeroides has been known as an oxygen- and light-dependent repressor of bacteriochlorophyll and carotenoid biosynthesis genes and puc operons involved in photosystem development. However, the putative PpsR-binding sites, TGTN12ACA, are also located upstream of numerous nonphotosystem genes, thus raising the possibility that the role of PpsR is broader. To characterize the PpsR regulon, transcriptome profiling was performed on the wild-type strain grown at high and low oxygen tensions, on the strain overproducing PpsR, and on the ppsR mutant. Transcriptome analysis showed that PpsR primarily regulates photosystem genes; the consensus PpsR binding sequence is TGTcN10gACA (lowercase letters indicate lesser conservation); the presence of two binding sites is required for repression in vivo. These findings explain why numerous single TGTN12ACA sequences are nonfunctional. In addition to photosystem genes, the hemC and hemE genes involved in the early steps of tetrapyrrole biosynthesis were identified as new direct targets of PpsR repression. Unexpectedly, PpsR was found to indirectly repress the puf and puhA operons encoding photosystem core proteins. The upstream regions of these operons contain no PpsR binding sites. Involvement in regulation of these operons suggests that PpsR functions as a master regulator of photosystem development. Upregulation of the puf and puhA operons that resulted from ppsR inactivation was sufficient to restore the ability to grow phototrophically to the prrA mutant. PrrA, the global redox-dependent activator, was previously considered indispensable for phototrophic growth. It is revealed that the PrrBA and AppA-PpsR systems, believed to work independently, in fact interact and coordinately regulate photosystem development." @default.
• W2124085063 created "2016-06-24" @default.
• W2124085063 creator A5022406134 @default.
• W2124085063 creator A5033708358 @default.
• W2124085063 creator A5075399498 @default.
• W2124085063 date "2005-03-15" @default.
• W2124085063 modified "2023-09-27" @default.
• W2124085063 title "Transcriptome Analysis of the <i>Rhodobacter sphaeroides</i> PpsR Regulon: PpsR as a Master Regulator of Photosystem Development" @default.
• W2124085063 cites W1265763149 @default.
• W2124085063 cites W1496897999 @default.
• W2124085063 cites W1794107300 @default.
• W2124085063 cites W1900934458 @default.
• W2124085063 cites W1933317506 @default.
• W2124085063 cites W1965166479 @default.
• W2124085063 cites W1967250942 @default.
• W2124085063 cites W1967668674 @default.
• W2124085063 cites W1972010400 @default.
• W2124085063 cites W1973683804 @default.
• W2124085063 cites W1979651924 @default.
• W2124085063 cites W1987282101 @default.
• W2124085063 cites W1988591380 @default.
• W2124085063 cites W1994664110 @default.
• W2124085063 cites W2006002347 @default.
• W2124085063 cites W2011553700 @default.
• W2124085063 cites W2013780428 @default.
• W2124085063 cites W2018658988 @default.
• W2124085063 cites W2022817150 @default.
• W2124085063 cites W2026915445 @default.
• W2124085063 cites W2027229485 @default.
• W2124085063 cites W2035075507 @default.
• W2124085063 cites W2035959381 @default.
• W2124085063 cites W2037346924 @default.
• W2124085063 cites W2039876863 @default.
• W2124085063 cites W2060904314 @default.
• W2124085063 cites W2062828655 @default.
• W2124085063 cites W2068372232 @default.
• W2124085063 cites W2070048993 @default.
• W2124085063 cites W2088844778 @default.
• W2124085063 cites W2098453858 @default.
• W2124085063 cites W2100010083 @default.
• W2124085063 cites W2101500463 @default.
• W2124085063 cites W2101773174 @default.
• W2124085063 cites W2105603053 @default.
• W2124085063 cites W2109972881 @default.
• W2124085063 cites W2123150370 @default.
• W2124085063 cites W2131350123 @default.
• W2124085063 cites W2133429671 @default.
• W2124085063 cites W2136716836 @default.
• W2124085063 cites W2139534813 @default.
• W2124085063 cites W2139779774 @default.
• W2124085063 cites W2141316764 @default.
• W2124085063 cites W2141494560 @default.
• W2124085063 cites W2158266834 @default.
• W2124085063 doi "https://doi.org/10.1128/jb.187.6.2148-2156.2005" @default.
• W2124085063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1064034" @default.
• W2124085063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15743963" @default.
• W2124085063 hasPublicationYear "2005" @default.
• W2124085063 type Work @default.
• W2124085063 sameAs 2124085063 @default.
• W2124085063 citedByCount "67" @default.
• W2124085063 countsByYear W21240850632012 @default.
• W2124085063 countsByYear W21240850632013 @default.
• W2124085063 countsByYear W21240850632014 @default.
• W2124085063 countsByYear W21240850632015 @default.
• W2124085063 countsByYear W21240850632016 @default.
• W2124085063 countsByYear W21240850632017 @default.
• W2124085063 countsByYear W21240850632019 @default.
• W2124085063 countsByYear W21240850632020 @default.
• W2124085063 countsByYear W21240850632021 @default.
• W2124085063 countsByYear W21240850632022 @default.
• W2124085063 crossrefType "journal-article" @default.
• W2124085063 hasAuthorship W2124085063A5022406134 @default.
• W2124085063 hasAuthorship W2124085063A5033708358 @default.
• W2124085063 hasAuthorship W2124085063A5075399498 @default.
• W2124085063 hasBestOaLocation W21240850631 @default.
• W2124085063 hasConcept C104317684 @default.
• W2124085063 hasConcept C143065580 @default.
• W2124085063 hasConcept C150194340 @default.
• W2124085063 hasConcept C158448853 @default.
• W2124085063 hasConcept C162317418 @default.
• W2124085063 hasConcept C197322856 @default.
• W2124085063 hasConcept C203075996 @default.
• W2124085063 hasConcept C523546767 @default.
• W2124085063 hasConcept C54355233 @default.
• W2124085063 hasConcept C55493867 @default.
• W2124085063 hasConcept C62361671 @default.
• W2124085063 hasConcept C86803240 @default.
• W2124085063 hasConcept C98614847 @default.
• W2124085063 hasConceptScore W2124085063C104317684 @default.
• W2124085063 hasConceptScore W2124085063C143065580 @default.
• W2124085063 hasConceptScore W2124085063C150194340 @default.
• W2124085063 hasConceptScore W2124085063C158448853 @default.
• W2124085063 hasConceptScore W2124085063C162317418 @default.
• W2124085063 hasConceptScore W2124085063C197322856 @default.
• W2124085063 hasConceptScore W2124085063C203075996 @default.
• W2124085063 hasConceptScore W2124085063C523546767 @default.
• W2124085063 hasConceptScore W2124085063C54355233 @default.
• W2124085063 hasConceptScore W2124085063C55493867 @default.

• next