Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124092018> ?p ?o ?g. }
- W2124092018 endingPage "389" @default.
- W2124092018 startingPage "380" @default.
- W2124092018 abstract "Abstract The in vitro oxidation of low-density lipoprotein (LDL) by hypochlorous acid produces a modified form (HOCl-LDL) capable of stimulating platelet function. We now report that HOCl-LDL is highly effective at inducing platelet function, causing stable aggregation and α-granule secretion. Such stimulation depended on the presence of low levels of primary agonists such as adenosine diphosphate (ADP) and thrombin, or others like epinephrine (EPI) and macrophage-derived chemokine (MDC, CCL22). Agonist levels, which by themselves induced little or reversible aggregation, caused strong stable aggregation when combined with low levels of HOCl-LDL. Platelet activation by HOCl-LDL and ADP (1 μM) caused P-selectin (CD62P) exposure, without serotonin or adenosine triphosphate (ATP) secretion. Intracellular calcium levels rose slowly (from 100 to 200 nM) in response to HOCl-LDL alone and rapidly when combined with ADP to about 300 nM. p38 mitogen-activated protein kinase (MAPK) became phosphorylated in response to HOCl-LDL alone. This phosphorylation was not blocked by the protein kinase C (PKC) inhibitor bisindolylmaleimide, which reduced the extent of aggregation and calcium increase. However, the p38 MAPK inhibitor SB203580 blocked platelet aggregation and phosphorylation of p38 MAPK. These findings suggest that HOCl-LDL exposed during atherosclerotic plaque rupture, coupled with low levels of primary agonists, can rapidly induce extensive and stable thrombus formation. (Blood. 2004;104:380-389)" @default.
- W2124092018 created "2016-06-24" @default.
- W2124092018 creator A5041653462 @default.
- W2124092018 creator A5050327070 @default.
- W2124092018 creator A5071255962 @default.
- W2124092018 creator A5082177319 @default.
- W2124092018 date "2004-07-15" @default.
- W2124092018 modified "2023-10-15" @default.
- W2124092018 title "LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22)" @default.
- W2124092018 cites W1515001810 @default.
- W2124092018 cites W158801599 @default.
- W2124092018 cites W1592287085 @default.
- W2124092018 cites W1608256683 @default.
- W2124092018 cites W1653408396 @default.
- W2124092018 cites W171102902 @default.
- W2124092018 cites W1969200048 @default.
- W2124092018 cites W1970956968 @default.
- W2124092018 cites W1971309654 @default.
- W2124092018 cites W1972143347 @default.
- W2124092018 cites W1975905715 @default.
- W2124092018 cites W1982016018 @default.
- W2124092018 cites W1982278033 @default.
- W2124092018 cites W1982638309 @default.
- W2124092018 cites W1982733325 @default.
- W2124092018 cites W1984942613 @default.
- W2124092018 cites W1987749678 @default.
- W2124092018 cites W1991197142 @default.
- W2124092018 cites W1992887930 @default.
- W2124092018 cites W1993310669 @default.
- W2124092018 cites W1994463091 @default.
- W2124092018 cites W1995242394 @default.
- W2124092018 cites W1998423895 @default.
- W2124092018 cites W2011705916 @default.
- W2124092018 cites W2011785451 @default.
- W2124092018 cites W2012040337 @default.
- W2124092018 cites W2013204959 @default.
- W2124092018 cites W2013627255 @default.
- W2124092018 cites W2016217548 @default.
- W2124092018 cites W2016933463 @default.
- W2124092018 cites W2017040040 @default.
- W2124092018 cites W2017372035 @default.
- W2124092018 cites W2019926610 @default.
- W2124092018 cites W2035961359 @default.
- W2124092018 cites W2036218447 @default.
- W2124092018 cites W2036750318 @default.
- W2124092018 cites W2038117288 @default.
- W2124092018 cites W2040151118 @default.
- W2124092018 cites W2043240855 @default.
- W2124092018 cites W2043709197 @default.
- W2124092018 cites W2043748789 @default.
- W2124092018 cites W2047072031 @default.
- W2124092018 cites W2047442884 @default.
- W2124092018 cites W2047645266 @default.
- W2124092018 cites W2047759567 @default.
- W2124092018 cites W2048443303 @default.
- W2124092018 cites W2052022851 @default.
- W2124092018 cites W2060439746 @default.
- W2124092018 cites W2064839153 @default.
- W2124092018 cites W2068246606 @default.
- W2124092018 cites W2069732290 @default.
- W2124092018 cites W2071792310 @default.
- W2124092018 cites W2076526863 @default.
- W2124092018 cites W2078414710 @default.
- W2124092018 cites W2080904659 @default.
- W2124092018 cites W2087420395 @default.
- W2124092018 cites W2090406032 @default.
- W2124092018 cites W2093390692 @default.
- W2124092018 cites W2093420819 @default.
- W2124092018 cites W2093589023 @default.
- W2124092018 cites W2100090369 @default.
- W2124092018 cites W2101773230 @default.
- W2124092018 cites W2103127505 @default.
- W2124092018 cites W2103497749 @default.
- W2124092018 cites W2106415952 @default.
- W2124092018 cites W2117637600 @default.
- W2124092018 cites W2118480498 @default.
- W2124092018 cites W2120157044 @default.
- W2124092018 cites W2120344355 @default.
- W2124092018 cites W2121225801 @default.
- W2124092018 cites W2128936422 @default.
- W2124092018 cites W2138841151 @default.
- W2124092018 cites W2139718485 @default.
- W2124092018 cites W2139905203 @default.
- W2124092018 cites W2141409038 @default.
- W2124092018 cites W2141583613 @default.
- W2124092018 cites W2141759373 @default.
- W2124092018 cites W2142527036 @default.
- W2124092018 cites W2154796306 @default.
- W2124092018 cites W2168169159 @default.
- W2124092018 cites W2168897708 @default.
- W2124092018 cites W2171056569 @default.
- W2124092018 cites W2324841714 @default.
- W2124092018 cites W2398399785 @default.
- W2124092018 cites W2405944457 @default.
- W2124092018 cites W2413521084 @default.
- W2124092018 cites W2414213917 @default.
- W2124092018 cites W2460301946 @default.
- W2124092018 cites W32351545 @default.