FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124096407> ?p ?o ?g. }

• W2124096407 endingPage "1747" @default.
• W2124096407 startingPage "1739" @default.
• W2124096407 abstract "Restenosis after angioplasty remains a major clinical problem. Prostaglandin E(2) (PGE(2)) plays an important role in vascular homeostasis. The PGE(2) receptor E-prostanoid 2 (EP2) is involved in the proliferation and migration of various cell types. We aimed to determine the role of EP2 in the pathogenesis of neointimal formation after vascular injury.Wire-mediated vascular injury was induced in the femoral arteries of male wild-type (EP2+/+) and EP2 gene-deficient (EP2-/-) mice. In EP2+/+ mice, EP2 mRNA expression was increased in injured vessels for at least 4 weeks after vascular injury. Neointimal hyperplasia was markedly accelerated in EP2-/- mice, which was associated with increased proliferation and migration of vascular smooth muscle cells (VSMCs) and increased cyclin D1 expression in the neointima layer. Platelet-derived growth factor-BB (PDGF-BB) treatment resulted in more significant cell proliferation and migration in VSMCs of EP2-/- mice than in those of EP2+/+ mice. Activation and overexpression of EP2 attenuated PDGF-BB-elicited cell proliferation and migration, induced G(1)→S-phase arrest and reduced PDGF-BB-stimulated extracellular signal-regulated kinase phosphorylation in EP2+/+ VSMCs.These findings reveal a novel role of the EP2 receptor in neointimal hyperplasia after arterial injury. The EP2 receptor may represent a potential therapeutic target for restenosis after angioplasty." @default.
• W2124096407 created "2016-06-24" @default.
• W2124096407 creator A5005296486 @default.
• W2124096407 creator A5010558103 @default.
• W2124096407 creator A5037477315 @default.
• W2124096407 creator A5052961193 @default.
• W2124096407 creator A5060239691 @default.
• W2124096407 creator A5060448158 @default.
• W2124096407 creator A5062607187 @default.
• W2124096407 creator A5074066583 @default.
• W2124096407 creator A5082061805 @default.
• W2124096407 creator A5083437982 @default.
• W2124096407 creator A5091188597 @default.
• W2124096407 date "2011-08-01" @default.
• W2124096407 modified "2023-10-18" @default.
• W2124096407 title "Targeted Disruption of the Prostaglandin E ₂ E-Prostanoid 2 Receptor Exacerbates Vascular Neointimal Formation in Mice" @default.
• W2124096407 cites W1500509176 @default.
• W2124096407 cites W1964171385 @default.
• W2124096407 cites W1969311477 @default.
• W2124096407 cites W1975160859 @default.
• W2124096407 cites W1979861588 @default.
• W2124096407 cites W1989926395 @default.
• W2124096407 cites W1990530751 @default.
• W2124096407 cites W1992046153 @default.
• W2124096407 cites W1996692411 @default.
• W2124096407 cites W2010360728 @default.
• W2124096407 cites W2015219342 @default.
• W2124096407 cites W2015233094 @default.
• W2124096407 cites W2018706226 @default.
• W2124096407 cites W2021226726 @default.
• W2124096407 cites W2025653938 @default.
• W2124096407 cites W2030571587 @default.
• W2124096407 cites W2039258264 @default.
• W2124096407 cites W2051904824 @default.
• W2124096407 cites W2052894211 @default.
• W2124096407 cites W2055047003 @default.
• W2124096407 cites W2057567330 @default.
• W2124096407 cites W2058498122 @default.
• W2124096407 cites W2058824933 @default.
• W2124096407 cites W2059915925 @default.
• W2124096407 cites W2063277519 @default.
• W2124096407 cites W2066689232 @default.
• W2124096407 cites W2066779825 @default.
• W2124096407 cites W2066833708 @default.
• W2124096407 cites W207410277 @default.
• W2124096407 cites W2074882038 @default.
• W2124096407 cites W2079674406 @default.
• W2124096407 cites W2100592123 @default.
• W2124096407 cites W2117125674 @default.
• W2124096407 cites W2121612337 @default.
• W2124096407 cites W2128987179 @default.
• W2124096407 cites W2131590447 @default.
• W2124096407 cites W2131732462 @default.
• W2124096407 cites W2140476780 @default.
• W2124096407 cites W2145772474 @default.
• W2124096407 cites W2147189648 @default.
• W2124096407 cites W2147247409 @default.
• W2124096407 cites W2150755435 @default.
• W2124096407 cites W2170825031 @default.
• W2124096407 cites W4253087849 @default.
• W2124096407 doi "https://doi.org/10.1161/atvbaha.111.226142" @default.
• W2124096407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21636806" @default.
• W2124096407 hasPublicationYear "2011" @default.
• W2124096407 type Work @default.
• W2124096407 sameAs 2124096407 @default.
• W2124096407 citedByCount "21" @default.
• W2124096407 countsByYear W21240964072012 @default.
• W2124096407 countsByYear W21240964072013 @default.
• W2124096407 countsByYear W21240964072014 @default.
• W2124096407 countsByYear W21240964072015 @default.
• W2124096407 countsByYear W21240964072016 @default.
• W2124096407 countsByYear W21240964072018 @default.
• W2124096407 countsByYear W21240964072019 @default.
• W2124096407 countsByYear W21240964072020 @default.
• W2124096407 countsByYear W21240964072021 @default.
• W2124096407 countsByYear W21240964072022 @default.
• W2124096407 crossrefType "journal-article" @default.
• W2124096407 hasAuthorship W2124096407A5005296486 @default.
• W2124096407 hasAuthorship W2124096407A5010558103 @default.
• W2124096407 hasAuthorship W2124096407A5037477315 @default.
• W2124096407 hasAuthorship W2124096407A5052961193 @default.
• W2124096407 hasAuthorship W2124096407A5060239691 @default.
• W2124096407 hasAuthorship W2124096407A5060448158 @default.
• W2124096407 hasAuthorship W2124096407A5062607187 @default.
• W2124096407 hasAuthorship W2124096407A5074066583 @default.
• W2124096407 hasAuthorship W2124096407A5082061805 @default.
• W2124096407 hasAuthorship W2124096407A5083437982 @default.
• W2124096407 hasAuthorship W2124096407A5091188597 @default.
• W2124096407 hasBestOaLocation W21240964071 @default.
• W2124096407 hasConcept C126322002 @default.
• W2124096407 hasConcept C134018914 @default.
• W2124096407 hasConcept C170493617 @default.
• W2124096407 hasConcept C178592051 @default.
• W2124096407 hasConcept C2777339539 @default.
• W2124096407 hasConcept C2778095995 @default.
• W2124096407 hasConcept C2778283817 @default.
• W2124096407 hasConcept C2778583881 @default.
• W2124096407 hasConcept C2778938600 @default.

• next