Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124111521> ?p ?o ?g. }
- W2124111521 endingPage "337" @default.
- W2124111521 startingPage "307" @default.
- W2124111521 abstract "Takahashi, Kunitaro, and Yasushi Okamura. Ion Channels and Early Development of Neural Cells. Physiol. Rev. 78: 307–337, 1998. — In this review, we underscore the merits of using voltage-dependent ion channels as markers for neuronal differentiation from the early stages of uncommitted embryonic blastomeres. Furthermore, a fairly large part of the review is devoted to the descriptions of the establishment of a simple model system for neural induction derived from the cleavage-arrested eight-cell ascidian embryo by pairing a single ectodermal with a single vegetal blastomere as a competent and an inducer cell, respectively. The descriptions are focused particularly on the early developmental processes of various ion channels in neuronal and other excitable membranes observed in this extraordinarily simple system, and we compare these results with those in other significant and definable systems for neural differentiation. It is stressed that this simple system, for which most of the electronic and optical methods and various injection experiments are applicable, may be useful for future molecular physiological studies on the intracellular process of differentiation of the early embryonic cells. We have also highlighted the importance of suppressive mechanisms for cellular differentiation from the experimental results, such as epidermal commitment of the cleavage-arrested one-cell Halocynthia embryos or suppression of epidermal-specific transcription of inward rectifier channels by neural induction signals. It was suggested that reciprocal suppressive mechanisms at the transcriptional level may be one of the key processes for cellular differentiation, by which exclusivity of cell types is maintained." @default.
- W2124111521 created "2016-06-24" @default.
- W2124111521 creator A5018817210 @default.
- W2124111521 creator A5041231691 @default.
- W2124111521 date "1998-04-01" @default.
- W2124111521 modified "2023-09-24" @default.
- W2124111521 title "Ion Channels and Early Development of Neural Cells" @default.
- W2124111521 cites W1480363003 @default.
- W2124111521 cites W1494525315 @default.
- W2124111521 cites W1497892412 @default.
- W2124111521 cites W1498591475 @default.
- W2124111521 cites W1501580127 @default.
- W2124111521 cites W1515446556 @default.
- W2124111521 cites W1530462575 @default.
- W2124111521 cites W1534975287 @default.
- W2124111521 cites W1547999461 @default.
- W2124111521 cites W1578677172 @default.
- W2124111521 cites W1582530932 @default.
- W2124111521 cites W1596141725 @default.
- W2124111521 cites W1664602277 @default.
- W2124111521 cites W1684106405 @default.
- W2124111521 cites W1763157023 @default.
- W2124111521 cites W1807534989 @default.
- W2124111521 cites W1813092835 @default.
- W2124111521 cites W1829204658 @default.
- W2124111521 cites W1835505633 @default.
- W2124111521 cites W1860007525 @default.
- W2124111521 cites W1863695472 @default.
- W2124111521 cites W1866331480 @default.
- W2124111521 cites W1866942422 @default.
- W2124111521 cites W1923688770 @default.
- W2124111521 cites W1933683602 @default.
- W2124111521 cites W1946763792 @default.
- W2124111521 cites W1961074127 @default.
- W2124111521 cites W1964629878 @default.
- W2124111521 cites W1965335273 @default.
- W2124111521 cites W1966135993 @default.
- W2124111521 cites W1966548950 @default.
- W2124111521 cites W1966799733 @default.
- W2124111521 cites W1967761879 @default.
- W2124111521 cites W1968177638 @default.
- W2124111521 cites W1968766520 @default.
- W2124111521 cites W1968844913 @default.
- W2124111521 cites W1969576250 @default.
- W2124111521 cites W1969775555 @default.
- W2124111521 cites W1969807505 @default.
- W2124111521 cites W1970587959 @default.
- W2124111521 cites W1971050495 @default.
- W2124111521 cites W1971070994 @default.
- W2124111521 cites W1972833869 @default.
- W2124111521 cites W1972960861 @default.
- W2124111521 cites W1975127012 @default.
- W2124111521 cites W1975260251 @default.
- W2124111521 cites W1975485655 @default.
- W2124111521 cites W1975816132 @default.
- W2124111521 cites W1975953566 @default.
- W2124111521 cites W1975987121 @default.
- W2124111521 cites W1976153661 @default.
- W2124111521 cites W1978811112 @default.
- W2124111521 cites W1979050181 @default.
- W2124111521 cites W1979264889 @default.
- W2124111521 cites W1979856671 @default.
- W2124111521 cites W1980148057 @default.
- W2124111521 cites W1980166477 @default.
- W2124111521 cites W1980848487 @default.
- W2124111521 cites W1982066307 @default.
- W2124111521 cites W1983361084 @default.
- W2124111521 cites W1983588871 @default.
- W2124111521 cites W1984210010 @default.
- W2124111521 cites W1984724499 @default.
- W2124111521 cites W1985146688 @default.
- W2124111521 cites W1987401965 @default.
- W2124111521 cites W1987763262 @default.
- W2124111521 cites W1988414756 @default.
- W2124111521 cites W1988569809 @default.
- W2124111521 cites W1989251445 @default.
- W2124111521 cites W1989527608 @default.
- W2124111521 cites W1989569240 @default.
- W2124111521 cites W1991729136 @default.
- W2124111521 cites W1992553904 @default.
- W2124111521 cites W1994512200 @default.
- W2124111521 cites W1995012072 @default.
- W2124111521 cites W1995149255 @default.
- W2124111521 cites W1995373035 @default.
- W2124111521 cites W1995376834 @default.
- W2124111521 cites W1995383479 @default.
- W2124111521 cites W1995865634 @default.
- W2124111521 cites W1997219362 @default.
- W2124111521 cites W1997923583 @default.
- W2124111521 cites W1998245021 @default.
- W2124111521 cites W1998273541 @default.
- W2124111521 cites W1999256080 @default.
- W2124111521 cites W1999770573 @default.
- W2124111521 cites W1999795837 @default.
- W2124111521 cites W1999935601 @default.
- W2124111521 cites W2001072459 @default.
- W2124111521 cites W2002638704 @default.
- W2124111521 cites W2003360892 @default.