Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124111730> ?p ?o ?g. }
- W2124111730 endingPage "3032" @default.
- W2124111730 startingPage "3018" @default.
- W2124111730 abstract "Hypoxia-inducible factor 1 (HIF1) is a master regulator of adaptive gene expression under hypoxia. However, a role for HIF1 in the epigenetic regulation remains unknown. Genome-wide analysis of HIF1 binding sites (chromatin immunoprecipitation [ChIP] with deep sequencing) of endothelial cells clarified that HIF1 mainly binds to the intergenic regions distal from transcriptional starting sites under both normoxia and hypoxia. Next, we examined the temporal profile of gene expression under hypoxic conditions by using DNA microarrays. We clarified that early hypoxia-responsive genes are functionally associated with glycolysis, including GLUT3 (SLC2A3). Acetylated lysine 27 of histone 3 covered the HIF1 binding sites, and HIF1 functioned as an enhancer of SLC2A3 by interaction with lysine (K)-specific demethylase 3A (KDM3A). Knockdown of HIF1α and KDM3A showed that glycolytic genes are regulated by both HIF1 and KDM3A and respond to hypoxia in a manner independent of cell type specificity. We elucidated that both the chromatin conformational structure and histone modification change under hypoxic conditions and enhance the expression of SLC2A3 based on the combined results of chromatin conformation capture (3C) and ChIP assays. KDM3A is recruited to the SLC2A3 locus in an HIF1-dependent manner and demethylates H3K9me2 so as to upregulate its expression. These findings provide novel insights into the interaction between HIF1 and KDM3A and also the epigenetic regulation of HIF1." @default.
- W2124111730 created "2016-06-24" @default.
- W2124111730 creator A5000287499 @default.
- W2124111730 creator A5001413231 @default.
- W2124111730 creator A5004592307 @default.
- W2124111730 creator A5007970106 @default.
- W2124111730 creator A5009811167 @default.
- W2124111730 creator A5014010927 @default.
- W2124111730 creator A5014464488 @default.
- W2124111730 creator A5019269482 @default.
- W2124111730 creator A5034239392 @default.
- W2124111730 creator A5036113498 @default.
- W2124111730 creator A5045784267 @default.
- W2124111730 creator A5054148476 @default.
- W2124111730 creator A5060288823 @default.
- W2124111730 creator A5064072579 @default.
- W2124111730 creator A5065776591 @default.
- W2124111730 creator A5071033580 @default.
- W2124111730 creator A5073245835 @default.
- W2124111730 creator A5074142176 @default.
- W2124111730 creator A5077985868 @default.
- W2124111730 creator A5085203051 @default.
- W2124111730 date "2012-08-01" @default.
- W2124111730 modified "2023-10-12" @default.
- W2124111730 title "Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A" @default.
- W2124111730 cites W1480115800 @default.
- W2124111730 cites W1503667331 @default.
- W2124111730 cites W1965584762 @default.
- W2124111730 cites W1969734439 @default.
- W2124111730 cites W1972002559 @default.
- W2124111730 cites W1975511655 @default.
- W2124111730 cites W1981487137 @default.
- W2124111730 cites W1985621639 @default.
- W2124111730 cites W1988377666 @default.
- W2124111730 cites W1991346678 @default.
- W2124111730 cites W1993487480 @default.
- W2124111730 cites W2001401534 @default.
- W2124111730 cites W2001544028 @default.
- W2124111730 cites W2011810742 @default.
- W2124111730 cites W2017575850 @default.
- W2124111730 cites W2018008610 @default.
- W2124111730 cites W2022451432 @default.
- W2124111730 cites W2040031153 @default.
- W2124111730 cites W2041973176 @default.
- W2124111730 cites W2046440184 @default.
- W2124111730 cites W2048865995 @default.
- W2124111730 cites W2053894221 @default.
- W2124111730 cites W2060903701 @default.
- W2124111730 cites W2063301376 @default.
- W2124111730 cites W2073026107 @default.
- W2124111730 cites W2075054245 @default.
- W2124111730 cites W2079121632 @default.
- W2124111730 cites W2082483448 @default.
- W2124111730 cites W2092409918 @default.
- W2124111730 cites W2092603991 @default.
- W2124111730 cites W2097220641 @default.
- W2124111730 cites W2104333975 @default.
- W2124111730 cites W2109661060 @default.
- W2124111730 cites W2113945778 @default.
- W2124111730 cites W2123564569 @default.
- W2124111730 cites W2130410032 @default.
- W2124111730 cites W2130440656 @default.
- W2124111730 cites W2133148543 @default.
- W2124111730 cites W2134881764 @default.
- W2124111730 cites W2144011204 @default.
- W2124111730 cites W2151309632 @default.
- W2124111730 cites W2154746182 @default.
- W2124111730 cites W2159831588 @default.
- W2124111730 cites W2162865304 @default.
- W2124111730 cites W2167776710 @default.
- W2124111730 doi "https://doi.org/10.1128/mcb.06643-11" @default.
- W2124111730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3434521" @default.
- W2124111730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22645302" @default.
- W2124111730 hasPublicationYear "2012" @default.
- W2124111730 type Work @default.
- W2124111730 sameAs 2124111730 @default.
- W2124111730 citedByCount "203" @default.
- W2124111730 countsByYear W21241117302012 @default.
- W2124111730 countsByYear W21241117302013 @default.
- W2124111730 countsByYear W21241117302014 @default.
- W2124111730 countsByYear W21241117302015 @default.
- W2124111730 countsByYear W21241117302016 @default.
- W2124111730 countsByYear W21241117302017 @default.
- W2124111730 countsByYear W21241117302018 @default.
- W2124111730 countsByYear W21241117302019 @default.
- W2124111730 countsByYear W21241117302020 @default.
- W2124111730 countsByYear W21241117302021 @default.
- W2124111730 countsByYear W21241117302022 @default.
- W2124111730 countsByYear W21241117302023 @default.
- W2124111730 crossrefType "journal-article" @default.
- W2124111730 hasAuthorship W2124111730A5000287499 @default.
- W2124111730 hasAuthorship W2124111730A5001413231 @default.
- W2124111730 hasAuthorship W2124111730A5004592307 @default.
- W2124111730 hasAuthorship W2124111730A5007970106 @default.
- W2124111730 hasAuthorship W2124111730A5009811167 @default.
- W2124111730 hasAuthorship W2124111730A5014010927 @default.
- W2124111730 hasAuthorship W2124111730A5014464488 @default.
- W2124111730 hasAuthorship W2124111730A5019269482 @default.