FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124114689> ?p ?o ?g. }

• W2124114689 endingPage "3589" @default.
• W2124114689 startingPage "3577" @default.
• W2124114689 abstract "Photoreceptor outer segments (OSs) are essential for our visual perception, and take either rod or cone forms. The cell biological basis for the formation of rods is well established; however, the mechanism of cone formation is ill characterized. While Xenopus rods are called rods, they exhibit cone-shaped OSs during the early process of development. To visualize the dynamic reorganization of disk membranes, opsin and peripherin/rds were fused to a fluorescent protein, Dendra2, and expressed in early developing rod photoreceptors, in which OSs are still cone-shaped. Dendra2 is a fluorescent protein which can be converted from green to red irreversibly, and thus allows spatiotemporal labeling of proteins. Using a photoconversion technique, we found that disk membranes are assembled at the base of cone-shaped OSs. After incorporation into disks, however, Opsin-Dendra2 was also trafficked from old to new disk membranes, consistent with the hypothesis that retrograde trafficking of membrane components contributes to the larger disk membrane observed toward the base of the cone-shaped OS. Such retrograde trafficking is cargo-specific and was not observed for peripherin/rds-Dendra2. The trafficking is unlikely mediated by diffusion, since the disk membranes have a closed configuration, as evidenced by CNGA1 labeling of the plasma membrane. Consistent with retrograde trafficking, the axoneme, which potentially mediates retrograde intraflagellar trafficking, runs through the entire axis of OSs. This study provides an insight into the role of membrane reorganization in developing photoreceptor OSs, and proves that retrograde trafficking of membrane cargoes can occur there." @default.
• W2124114689 created "2016-06-24" @default.
• W2124114689 creator A5003113969 @default.
• W2124114689 creator A5042148986 @default.
• W2124114689 creator A5066169695 @default.
• W2124114689 creator A5087942849 @default.
• W2124114689 date "2014-06-10" @default.
• W2124114689 modified "2023-10-10" @default.
• W2124114689 title "Retrograde intraciliary trafficking of opsin during the maintenance of cone-shaped photoreceptor outer segments of<i>Xenopus laevis</i>" @default.
• W2124114689 cites W1976113780 @default.
• W2124114689 cites W1981810671 @default.
• W2124114689 cites W1982442386 @default.
• W2124114689 cites W1993252863 @default.
• W2124114689 cites W1995497500 @default.
• W2124114689 cites W1996743997 @default.
• W2124114689 cites W2000205353 @default.
• W2124114689 cites W2005523433 @default.
• W2124114689 cites W2006729726 @default.
• W2124114689 cites W2030411778 @default.
• W2124114689 cites W2037709331 @default.
• W2124114689 cites W2044819310 @default.
• W2124114689 cites W2086754614 @default.
• W2124114689 cites W2086790354 @default.
• W2124114689 cites W2098770288 @default.
• W2124114689 cites W2105837695 @default.
• W2124114689 cites W2105876104 @default.
• W2124114689 cites W2110394648 @default.
• W2124114689 cites W2111416310 @default.
• W2124114689 cites W2118200380 @default.
• W2124114689 cites W2119960283 @default.
• W2124114689 cites W2123814643 @default.
• W2124114689 cites W2126878033 @default.
• W2124114689 cites W2127210883 @default.
• W2124114689 cites W2152579394 @default.
• W2124114689 cites W2156877730 @default.
• W2124114689 cites W4211143281 @default.
• W2124114689 doi "https://doi.org/10.1002/cne.23630" @default.
• W2124114689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4142104" @default.
• W2124114689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24855015" @default.
• W2124114689 hasPublicationYear "2014" @default.
• W2124114689 type Work @default.
• W2124114689 sameAs 2124114689 @default.
• W2124114689 citedByCount "11" @default.
• W2124114689 countsByYear W21241146892015 @default.
• W2124114689 countsByYear W21241146892016 @default.
• W2124114689 countsByYear W21241146892019 @default.
• W2124114689 countsByYear W21241146892020 @default.
• W2124114689 countsByYear W21241146892021 @default.
• W2124114689 crossrefType "journal-article" @default.
• W2124114689 hasAuthorship W2124114689A5003113969 @default.
• W2124114689 hasAuthorship W2124114689A5042148986 @default.
• W2124114689 hasAuthorship W2124114689A5066169695 @default.
• W2124114689 hasAuthorship W2124114689A5087942849 @default.
• W2124114689 hasBestOaLocation W21241146892 @default.
• W2124114689 hasConcept C104317684 @default.
• W2124114689 hasConcept C105702510 @default.
• W2124114689 hasConcept C12554922 @default.
• W2124114689 hasConcept C169760540 @default.
• W2124114689 hasConcept C202033177 @default.
• W2124114689 hasConcept C2777093970 @default.
• W2124114689 hasConcept C2779535977 @default.
• W2124114689 hasConcept C2780827179 @default.
• W2124114689 hasConcept C28521208 @default.
• W2124114689 hasConcept C30028475 @default.
• W2124114689 hasConcept C41625074 @default.
• W2124114689 hasConcept C55493867 @default.
• W2124114689 hasConcept C86803240 @default.
• W2124114689 hasConcept C95444343 @default.
• W2124114689 hasConceptScore W2124114689C104317684 @default.
• W2124114689 hasConceptScore W2124114689C105702510 @default.
• W2124114689 hasConceptScore W2124114689C12554922 @default.
• W2124114689 hasConceptScore W2124114689C169760540 @default.
• W2124114689 hasConceptScore W2124114689C202033177 @default.
• W2124114689 hasConceptScore W2124114689C2777093970 @default.
• W2124114689 hasConceptScore W2124114689C2779535977 @default.
• W2124114689 hasConceptScore W2124114689C2780827179 @default.
• W2124114689 hasConceptScore W2124114689C28521208 @default.
• W2124114689 hasConceptScore W2124114689C30028475 @default.
• W2124114689 hasConceptScore W2124114689C41625074 @default.
• W2124114689 hasConceptScore W2124114689C55493867 @default.
• W2124114689 hasConceptScore W2124114689C86803240 @default.
• W2124114689 hasConceptScore W2124114689C95444343 @default.
• W2124114689 hasFunder F4320337350 @default.
• W2124114689 hasIssue "16" @default.
• W2124114689 hasLocation W21241146891 @default.
• W2124114689 hasLocation W21241146892 @default.
• W2124114689 hasLocation W21241146893 @default.
• W2124114689 hasLocation W21241146894 @default.
• W2124114689 hasOpenAccess W2124114689 @default.
• W2124114689 hasPrimaryLocation W21241146891 @default.
• W2124114689 hasRelatedWork W101883115 @default.
• W2124114689 hasRelatedWork W1603853902 @default.
• W2124114689 hasRelatedWork W1882458725 @default.
• W2124114689 hasRelatedWork W2009477947 @default.
• W2124114689 hasRelatedWork W2014201996 @default.
• W2124114689 hasRelatedWork W2063262136 @default.
• W2124114689 hasRelatedWork W2085572971 @default.
• W2124114689 hasRelatedWork W2102549296 @default.

• next