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- W2124118375 abstract "Neonatal rabbits were injected with large amounts of pooled normal A/Jax strain mouse liver and serum to induce tolerance to the organ and species antigens present in this mixture. At 3 months of age, the tolerant and uninjected control rabbits were all challenged with either A/Jax strain heart and (or) liver or kidney and their responses were compared by precipitation, hemagglutination (HA), and indirect fluorescent antibody tests (IFab). The normal sera showed one to four precipitation arcs on two-dimensional immunodiffusion analysis against their respective organ antigens and those demonstrable on immunoelectrophoresis migrated predominantly in the β and γ globulin regions. Organ-specific antibodies reacting with the organ antigens of the immunizing species and heterologous species were easily quantified by HA titrations and localized by IFab tests. It was noted that antigens common to the tissues of the immunizing species were found principally in the supportive cell structures whereas organ-specific antigens were found in the cytoplasmic region of the immunizing tissue and in similar tissues of different species.Antisera derived from the tolerant rabbits immunized with heart and (or) liver showed virtually normal heart specific responses while the response to liver was significantly suppressed. The complete absence of the cross reaction to guinea pig liver in the tolerant sera was taken as evidence of the tolerance mediated suppression of the reactivity to some of the mouse liver antigenic determinants." @default.
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- W2124118375 date "1971-04-01" @default.
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- W2124118375 title "Studies of tolerance to organ antigens. The immune response to A/Jax strain mouse organs in normal and A/Jax strain mouse liver tolerant rabbits" @default.
- W2124118375 doi "https://doi.org/10.1139/m71-078" @default.
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