FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124138766> ?p ?o ?g. }

• W2124138766 endingPage "936" @default.
• W2124138766 startingPage "930" @default.
• W2124138766 abstract "Mutations in the cardiac myosin binding protein-C gene (cMyBP-C) are among the most prevalent causes of inherited hypertrophic cardiomyopathy. Although most cMyBP-C mutations cause reading frameshifts that are predicted to encode truncated peptides, it is not known if or how expression of these peptides causes disease. One possibility is that because the N-terminus contains a unique binding site for the S2 subfragment of myosin, shortened cMyBP-C peptides could directly affect myosin contraction by binding to S2. To test this hypothesis, we compared the effects of a C1C2 protein containing the myosin S2 binding site on contractile properties in permeabilized myocytes from wild-type and cMyBP-C knockout mice. In wild-type myocytes, the C1C2 protein reversibly increased myofilament Ca2+ sensitivity of tension, but had no effect on resting tension. Identical results were observed in cMyBP-C knockout myocytes where C1C2 increased Ca2+ sensitivity of tension with the half-maximal response elicited at approximately 5 micromol/L C1C2. Maximum force was not affected by C1C2. However, phosphorylation of C1C2 by cAMP-dependent protein kinase reduced its ability to increase Ca2+ sensitivity. These results demonstrate that binding of the C1C2 peptide to S2 alone is sufficient to affect myosin contractile function and suggest that regulated binding of cMyBP-C to myosin S2 by phosphorylation directly influences myofilament Ca2+ sensitivity." @default.
• W2124138766 created "2016-06-24" @default.
• W2124138766 creator A5028123697 @default.
• W2124138766 creator A5049291585 @default.
• W2124138766 creator A5053571370 @default.
• W2124138766 creator A5081307424 @default.
• W2124138766 date "2004-10-29" @default.
• W2124138766 modified "2023-10-10" @default.
• W2124138766 title "Binding of Myosin Binding Protein-C to Myosin Subfragment S2 Affects Contractility Independent of a Tether Mechanism" @default.
• W2124138766 cites W1233659682 @default.
• W2124138766 cites W1511283545 @default.
• W2124138766 cites W1606423922 @default.
• W2124138766 cites W1840801780 @default.
• W2124138766 cites W1886836779 @default.
• W2124138766 cites W1894212022 @default.
• W2124138766 cites W1963480873 @default.
• W2124138766 cites W1978363532 @default.
• W2124138766 cites W1980831425 @default.
• W2124138766 cites W1993333724 @default.
• W2124138766 cites W2011075985 @default.
• W2124138766 cites W2024157010 @default.
• W2124138766 cites W2027613848 @default.
• W2124138766 cites W2043130547 @default.
• W2124138766 cites W2043182417 @default.
• W2124138766 cites W2056219308 @default.
• W2124138766 cites W2061790077 @default.
• W2124138766 cites W2062133386 @default.
• W2124138766 cites W2072393541 @default.
• W2124138766 cites W2079482882 @default.
• W2124138766 cites W2084747396 @default.
• W2124138766 cites W2092771760 @default.
• W2124138766 cites W2100822265 @default.
• W2124138766 cites W2121519705 @default.
• W2124138766 cites W2127423627 @default.
• W2124138766 cites W2127783104 @default.
• W2124138766 cites W2140233227 @default.
• W2124138766 cites W2154064619 @default.
• W2124138766 cites W2159669366 @default.
• W2124138766 cites W2159830386 @default.
• W2124138766 cites W2166639588 @default.
• W2124138766 cites W2209566065 @default.
• W2124138766 cites W259174617 @default.
• W2124138766 cites W32746739 @default.
• W2124138766 cites W4252200392 @default.
• W2124138766 doi "https://doi.org/10.1161/01.res.0000147312.02673.56" @default.
• W2124138766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15472117" @default.
• W2124138766 hasPublicationYear "2004" @default.
• W2124138766 type Work @default.
• W2124138766 sameAs 2124138766 @default.
• W2124138766 citedByCount "72" @default.
• W2124138766 countsByYear W21241387662012 @default.
• W2124138766 countsByYear W21241387662013 @default.
• W2124138766 countsByYear W21241387662014 @default.
• W2124138766 countsByYear W21241387662015 @default.
• W2124138766 countsByYear W21241387662016 @default.
• W2124138766 countsByYear W21241387662017 @default.
• W2124138766 countsByYear W21241387662018 @default.
• W2124138766 countsByYear W21241387662019 @default.
• W2124138766 countsByYear W21241387662020 @default.
• W2124138766 countsByYear W21241387662021 @default.
• W2124138766 countsByYear W21241387662022 @default.
• W2124138766 countsByYear W21241387662023 @default.
• W2124138766 crossrefType "journal-article" @default.
• W2124138766 hasAuthorship W2124138766A5028123697 @default.
• W2124138766 hasAuthorship W2124138766A5049291585 @default.
• W2124138766 hasAuthorship W2124138766A5053571370 @default.
• W2124138766 hasAuthorship W2124138766A5081307424 @default.
• W2124138766 hasBestOaLocation W21241387661 @default.
• W2124138766 hasConcept C104317684 @default.
• W2124138766 hasConcept C107824862 @default.
• W2124138766 hasConcept C11960822 @default.
• W2124138766 hasConcept C134018914 @default.
• W2124138766 hasConcept C153911025 @default.
• W2124138766 hasConcept C174054327 @default.
• W2124138766 hasConcept C39133596 @default.
• W2124138766 hasConcept C553089730 @default.
• W2124138766 hasConcept C55493867 @default.
• W2124138766 hasConcept C6997183 @default.
• W2124138766 hasConcept C8035138 @default.
• W2124138766 hasConcept C86803240 @default.
• W2124138766 hasConcept C95444343 @default.
• W2124138766 hasConceptScore W2124138766C104317684 @default.
• W2124138766 hasConceptScore W2124138766C107824862 @default.
• W2124138766 hasConceptScore W2124138766C11960822 @default.
• W2124138766 hasConceptScore W2124138766C134018914 @default.
• W2124138766 hasConceptScore W2124138766C153911025 @default.
• W2124138766 hasConceptScore W2124138766C174054327 @default.
• W2124138766 hasConceptScore W2124138766C39133596 @default.
• W2124138766 hasConceptScore W2124138766C553089730 @default.
• W2124138766 hasConceptScore W2124138766C55493867 @default.
• W2124138766 hasConceptScore W2124138766C6997183 @default.
• W2124138766 hasConceptScore W2124138766C8035138 @default.
• W2124138766 hasConceptScore W2124138766C86803240 @default.
• W2124138766 hasConceptScore W2124138766C95444343 @default.
• W2124138766 hasIssue "9" @default.
• W2124138766 hasLocation W21241387661 @default.
• W2124138766 hasLocation W21241387662 @default.
• W2124138766 hasLocation W21241387663 @default.

• next