Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124181854> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2124181854 endingPage "79" @default.
- W2124181854 startingPage "73" @default.
- W2124181854 abstract "IL-4 and IL-13 share a wide range of activities on monocytes, epithelial cells and B cells and thus play an important role in host defense. Many of these activities are not conserved among species as human, but not murine, B cells are thought to be responsive to IL-13. We previously demonstrated that human IL-13 is highly conserved at the nucleic acid level with a candidate bovine IL-13 cDNA homologue. Moreover, recombinant human IL-13 stimulates Ig secretion by appropriately activated bovine B cells. These studies have been extended to examining Ig class switching at both the protein and mRNA levels in addition to examining other markers of cellular activation. Our results suggest that IL-13 influences B cell differentiation by enhancing IgM, IgG1, and IgE production. IL-13 stimulation alone increases MHC class II expression and progression through cell cycle, although at lower levels in comparison to rboIL-4. The biology of the receptors for IL-4 and IL-13 is complex and raises several key questions with regard to IL-4-dependent and -independent mechanisms of host immunomodulation. Recent studies suggest that at least four chains are involved. These include the p140 IL-4 binding chain (IL-4Ralpha), the common gamma chain (gammac chain), IL-13 receptor alpha- chain (IL-13Ralpha-1) and the IL-13 receptor alpha-2 chain (IL-13Ralpha-2). We have recently cloned cDNAs for the bovine homologues of the IL-13Ralpha-1 and IL-4Ralpha chains and evaluated mRNA expression for a variety of cell types following stimulation. The expression patterns and their implications for receptor chain utilization in signaling via these key TH2 signature cytokines will be discussed." @default.
- W2124181854 created "2016-06-24" @default.
- W2124181854 creator A5021992592 @default.
- W2124181854 creator A5051584890 @default.
- W2124181854 creator A5073443061 @default.
- W2124181854 date "1999-12-01" @default.
- W2124181854 modified "2023-09-27" @default.
- W2124181854 title "Functional implications for signaling via the IL4R/IL13R complex on bovine cells" @default.
- W2124181854 cites W1964458836 @default.
- W2124181854 cites W1966949222 @default.
- W2124181854 cites W1969912242 @default.
- W2124181854 cites W1970625093 @default.
- W2124181854 cites W1972624864 @default.
- W2124181854 cites W1974106712 @default.
- W2124181854 cites W2012738581 @default.
- W2124181854 cites W2052514685 @default.
- W2124181854 cites W2052605623 @default.
- W2124181854 cites W2077988464 @default.
- W2124181854 cites W2151599364 @default.
- W2124181854 doi "https://doi.org/10.1016/s0165-2427(99)00117-8" @default.
- W2124181854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10614495" @default.
- W2124181854 hasPublicationYear "1999" @default.
- W2124181854 type Work @default.
- W2124181854 sameAs 2124181854 @default.
- W2124181854 citedByCount "12" @default.
- W2124181854 countsByYear W21241818542015 @default.
- W2124181854 countsByYear W21241818542019 @default.
- W2124181854 countsByYear W21241818542020 @default.
- W2124181854 crossrefType "journal-article" @default.
- W2124181854 hasAuthorship W2124181854A5021992592 @default.
- W2124181854 hasAuthorship W2124181854A5051584890 @default.
- W2124181854 hasAuthorship W2124181854A5073443061 @default.
- W2124181854 hasConcept C104317684 @default.
- W2124181854 hasConcept C152204938 @default.
- W2124181854 hasConcept C153911025 @default.
- W2124181854 hasConcept C170493617 @default.
- W2124181854 hasConcept C191732599 @default.
- W2124181854 hasConcept C32046619 @default.
- W2124181854 hasConcept C40767141 @default.
- W2124181854 hasConcept C54355233 @default.
- W2124181854 hasConcept C86803240 @default.
- W2124181854 hasConcept C8891405 @default.
- W2124181854 hasConcept C95444343 @default.
- W2124181854 hasConceptScore W2124181854C104317684 @default.
- W2124181854 hasConceptScore W2124181854C152204938 @default.
- W2124181854 hasConceptScore W2124181854C153911025 @default.
- W2124181854 hasConceptScore W2124181854C170493617 @default.
- W2124181854 hasConceptScore W2124181854C191732599 @default.
- W2124181854 hasConceptScore W2124181854C32046619 @default.
- W2124181854 hasConceptScore W2124181854C40767141 @default.
- W2124181854 hasConceptScore W2124181854C54355233 @default.
- W2124181854 hasConceptScore W2124181854C86803240 @default.
- W2124181854 hasConceptScore W2124181854C8891405 @default.
- W2124181854 hasConceptScore W2124181854C95444343 @default.
- W2124181854 hasIssue "1-2" @default.
- W2124181854 hasLocation W21241818541 @default.
- W2124181854 hasLocation W21241818542 @default.
- W2124181854 hasOpenAccess W2124181854 @default.
- W2124181854 hasPrimaryLocation W21241818541 @default.
- W2124181854 hasRelatedWork W1531317003 @default.
- W2124181854 hasRelatedWork W1989950888 @default.
- W2124181854 hasRelatedWork W2023608933 @default.
- W2124181854 hasRelatedWork W2077773329 @default.
- W2124181854 hasRelatedWork W2077991892 @default.
- W2124181854 hasRelatedWork W2083420397 @default.
- W2124181854 hasRelatedWork W2344807959 @default.
- W2124181854 hasRelatedWork W2357110142 @default.
- W2124181854 hasRelatedWork W2529932474 @default.
- W2124181854 hasRelatedWork W2760028953 @default.
- W2124181854 hasVolume "72" @default.
- W2124181854 isParatext "false" @default.
- W2124181854 isRetracted "false" @default.
- W2124181854 magId "2124181854" @default.
- W2124181854 workType "article" @default.