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- W2124185700 abstract "SII-T1 is a tissue-specific member of the transcription elongation factor S-II that is expressed specifically in male germ cells. In the present study, we have identified a protein named GRIP1tau interacting with SII-T1 by yeast two-hybrid screening. GRIP1tau is a novel isoform of glutamate receptor-interacting protein 1 (GRIP1) that associates with the cytoplasmic domain of the alpha-amino-3-hydroxy-5-methyl-4-isoaxazolepropionate (AMPA)-type glutamate receptor. GRIP1tau is a testis-specific nuclear protein that activates transcription when fused with a GAL4 DNA binding domain in GAL4-responsive reporter gene assays. The transactivation domain of GRIP1tau overlapped with the region essential for interaction with SII-T1, as revealed by co-immunoprecipitation assays. Also, transactivation by GRIP1tau was stimulated by SII-T1 in a dose-dependent manner. Therefore, we propose that GRIP1tau is a novel testis-specific transcriptional activator regulated by interaction with the testis-specific transcription elongation factor SII-T1." @default.
- W2124185700 created "2016-06-24" @default.
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- W2124185700 date "2004-10-27" @default.
- W2124185700 modified "2023-10-13" @default.
- W2124185700 title "GRIP1τ, a novel PDZ domain‐containing transcriptional activator, cooperates with the testis‐specific transcription elongation factor SII‐T1" @default.
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- W2124185700 doi "https://doi.org/10.1111/j.1365-2443.2004.00795.x" @default.
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