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- W2124196649 abstract "—Cortex slices, synaptosomes and C-6 glioma cells were used to study [35S]taurine uptake and its electrically-stimulated release. After exposure to taurine at two concentrations, the synaptosome preparation subsequently derived from the slices contained 41% of the particle-bound taurine and 16% of the total in the tissue. The uptake of [14C]GABA by C-6 glioma cells was inhibited 3-fold more by β-alanine than by l-DABA, whilst synaptosome preparations showed the opposite pattern, l-DABA being 2 or 3 times more effective than β-alanine. [35S]Taurine uptake inhibition by l-DABA was low for synaptosomes and C-6 glioma, whereas β-alanine showed considerable effect on C-6 glioma (41%) and slices of white matter (ependyma; 50%). Synaptosome preparations showed little effect with β-alanine. When 30 min rather than 5 min incubations were employed, β-alanine depressed [35S]taurine uptake by cortex slices by 30%. Taurine was taken up by a calcium-dependent mechanism and subcellular fractionation indicated that the synaptosome fraction showed losses commensurate with the net taurine release when low stimulation currents were used." @default.
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- W2124196649 date "1979-07-01" @default.
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- W2124196649 title "UPTAKE AND RELEASE OF TAURINE FROM CEREBRAL CORTEX SLICES AND THEIR SUBCELLULAR COMPARTMENTS" @default.
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- W2124196649 doi "https://doi.org/10.1111/j.1471-4159.1979.tb11736.x" @default.
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