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• W2124205522 abstract "ABSTRACT β- N -Acetylglucosaminidase (NagZ), encoded by the nagZ gene, is a critical enzyme for basal-level ampC derepression ( ampC expression in the absence of β-lactam challenge) in ampD and dacB mutants of Pseudomonas aeruginosa . Three mutants with a phenotype of basal-level L1 and L2 β-lactamase derepression in Stenotrophomonas maltophilia have been reported, including KJΔDI ( ampD I mutant), KJΔmrcA ( mrcA mutant), and KJΔDIΔmrcA ( ampD I and mrcA double mutant). In this study, nagZ of S. maltophilia was characterized, and its roles in basal-level β-lactamase derepression, induced β-lactamase activities, and β-lactam resistance of KJΔDI, KJΔmrcA, and KJΔDIΔmrcA were evaluated. Expression of the nagZ gene was constitutive and not regulated by AmpR, AmpD I , AmpN, AmpG, PBP1a, and NagZ. Introduction of Δ nagZ into KJΔDI nearly abolished basal-level derepressed β-lactamase activity; conversely, introduction of Δ nagZ into KJΔmrcA did not affect it. At least two activator ligands (ALs) are thus considered responsible for β-lactamase expression in the S. maltophilia system, specifically, the NagZ-dependent (AL1) and NagZ-independent (AL2) ligands responsible for the basal-level derepressed β-lactamase activities of KJΔDI and KJΔmrcA, respectively. The contributions of AL1 and AL2 to the induced β-lactamase activities may vary with the types of β-lactams. nagZ inactivation did not affect aztreonam-, cefoxitin-, and carbenicillin-induced β-lactamase activities, but it attenuated cefuroxime- and piperacillin-induced β-lactamase activities. Introduction of Δ nagZ into KJ, KJΔDI, KJΔmrcA, and KJΔDIΔmrcA did not significantly change the MICs of the β-lactams tested except that the MICs of cefuroxime and piperacillin moderately decreased in strains KJΔZ and KJΔDIΔZ ( nagZ mutants)." @default.
• W2124205522 created "2016-06-24" @default.
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• W2124205522 date "2012-04-01" @default.
• W2124205522 modified "2023-09-25" @default.
• W2124205522 title "NagZ-Dependent and NagZ-Independent Mechanisms for β-Lactamase Expression in Stenotrophomonas maltophilia" @default.
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• W2124205522 doi "https://doi.org/10.1128/aac.05645-11" @default.
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