FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124207866> ?p ?o ?g. }

• W2124207866 endingPage "H2611" @default.
• W2124207866 startingPage "H2599" @default.
• W2124207866 abstract "Sustained therapeutic hypercapnia prevents pulmonary hypertension in experimental animals, but its rescue effects on established disease have not been studied. Therapies that inhibit Rho-kinase (ROCK) and/or augment nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling can reverse or prevent progression of chronic pulmonary hypertension. Our objective in the present study was to determine whether sustained rescue treatment with inhaled CO 2 (therapeutic hypercapnia) would improve structural and functional changes of chronic hypoxic pulmonary hypertension. Spontaneously breathing pups were exposed to normoxia (21% O 2 ) or hypoxia (13% O 2 ) from postnatal days 1–21 with or without 7% CO 2 (Pa CO 2 elevated by ∼25 mmHg) or 10% CO 2 (Pa CO 2 elevated by ∼40 mmHg) from days 14 to 21. Compared with hypoxia alone, animals exposed to hypoxia and 10% CO 2 had significantly ( P < 0.05) decreased pulmonary vascular resistance, right-ventricular systolic pressure, right-ventricular hypertrophy, and medial wall thickness of pulmonary resistance arteries as well as decreased lung phosphodiesterase (PDE) V, RhoA, and ROCK activity. Rescue treatment with 10% CO 2 , or treatment with a ROCK inhibitor (15 mg/kg ip Y-27632 twice daily from days 14 to 21), also increased pulmonary arterial endothelial nitric oxide synthase and lung NO content. In contrast, cGMP content and cGMP-dependent protein kinase (PKG) activity were increased by exposure to 10% CO 2 , but not by ROCK inhibition with Y-27632. In vitro exposure of pulmonary artery smooth muscle cells to hypercapnia suppressed serum-induced ROCK activity, which was prevented by inhibition of PKG with Rp-8-Br-PET-cGMPS. We conclude that sustained hypercapnia dose-dependently inhibited ROCK activity, augmented NO-cGMP-PKG signaling, and led to partial improvements in the hemodynamic and structural abnormalities of chronic hypoxic PHT in juvenile rats. Increased PKG content and activity appears to play a major upstream role in CO 2 -induced suppression of ROCK activity in pulmonary arterial smooth muscle." @default.
• W2124207866 created "2016-06-24" @default.
• W2124207866 creator A5000153788 @default.
• W2124207866 creator A5011460007 @default.
• W2124207866 creator A5022732813 @default.
• W2124207866 creator A5038793805 @default.
• W2124207866 creator A5048582533 @default.
• W2124207866 creator A5053939436 @default.
• W2124207866 creator A5063131038 @default.
• W2124207866 creator A5064936966 @default.
• W2124207866 creator A5077482664 @default.
• W2124207866 creator A5085189262 @default.
• W2124207866 creator A5091149521 @default.
• W2124207866 date "2012-06-15" @default.
• W2124207866 modified "2023-10-16" @default.
• W2124207866 title "Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats" @default.
• W2124207866 cites W1503549916 @default.
• W2124207866 cites W1508695192 @default.
• W2124207866 cites W1521890865 @default.
• W2124207866 cites W1964653374 @default.
• W2124207866 cites W1965244935 @default.
• W2124207866 cites W1968011743 @default.
• W2124207866 cites W1972392261 @default.
• W2124207866 cites W1973383826 @default.
• W2124207866 cites W1976188689 @default.
• W2124207866 cites W1978234307 @default.
• W2124207866 cites W1993379452 @default.
• W2124207866 cites W1994833196 @default.
• W2124207866 cites W1997047212 @default.
• W2124207866 cites W2000007398 @default.
• W2124207866 cites W2000797437 @default.
• W2124207866 cites W2001765162 @default.
• W2124207866 cites W2003578457 @default.
• W2124207866 cites W2005583772 @default.
• W2124207866 cites W2007685722 @default.
• W2124207866 cites W2014217144 @default.
• W2124207866 cites W2014864594 @default.
• W2124207866 cites W2017526058 @default.
• W2124207866 cites W2019102662 @default.
• W2124207866 cites W2019822857 @default.
• W2124207866 cites W2038261538 @default.
• W2124207866 cites W2038938013 @default.
• W2124207866 cites W2040301645 @default.
• W2124207866 cites W2042273969 @default.
• W2124207866 cites W2042877326 @default.
• W2124207866 cites W2047985166 @default.
• W2124207866 cites W2049915398 @default.
• W2124207866 cites W2051271714 @default.
• W2124207866 cites W2052022195 @default.
• W2124207866 cites W2052092902 @default.
• W2124207866 cites W2052188754 @default.
• W2124207866 cites W2052333628 @default.
• W2124207866 cites W2055362105 @default.
• W2124207866 cites W2056105288 @default.
• W2124207866 cites W2075194138 @default.
• W2124207866 cites W2081354423 @default.
• W2124207866 cites W2083968846 @default.
• W2124207866 cites W2099745042 @default.
• W2124207866 cites W2105862640 @default.
• W2124207866 cites W2106311731 @default.
• W2124207866 cites W2107771085 @default.
• W2124207866 cites W2109850479 @default.
• W2124207866 cites W2116684609 @default.
• W2124207866 cites W2121452261 @default.
• W2124207866 cites W2123886313 @default.
• W2124207866 cites W2130477727 @default.
• W2124207866 cites W2130685976 @default.
• W2124207866 cites W2130695838 @default.
• W2124207866 cites W2132458710 @default.
• W2124207866 cites W2134603143 @default.
• W2124207866 cites W2137377367 @default.
• W2124207866 cites W2138742704 @default.
• W2124207866 cites W2140651314 @default.
• W2124207866 cites W2142705676 @default.
• W2124207866 cites W2144804934 @default.
• W2124207866 cites W2145785767 @default.
• W2124207866 cites W2146479112 @default.
• W2124207866 cites W2148026002 @default.
• W2124207866 cites W2148065784 @default.
• W2124207866 cites W2161467739 @default.
• W2124207866 cites W2165054234 @default.
• W2124207866 cites W2165538436 @default.
• W2124207866 cites W2165997863 @default.
• W2124207866 cites W2169899861 @default.
• W2124207866 cites W2170752083 @default.
• W2124207866 cites W2258117099 @default.
• W2124207866 cites W2306754098 @default.
• W2124207866 cites W2397603283 @default.
• W2124207866 cites W2443693435 @default.
• W2124207866 cites W4251161234 @default.
• W2124207866 doi "https://doi.org/10.1152/ajpheart.01180.2011" @default.
• W2124207866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22505643" @default.
• W2124207866 hasPublicationYear "2012" @default.
• W2124207866 type Work @default.
• W2124207866 sameAs 2124207866 @default.
• W2124207866 citedByCount "23" @default.
• W2124207866 countsByYear W21242078662012 @default.
• W2124207866 countsByYear W21242078662013 @default.

• next