FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124209097> ?p ?o ?g. }

• W2124209097 endingPage "1290" @default.
• W2124209097 startingPage "1286" @default.
• W2124209097 abstract "Programmed cell death by apoptosis occurs in fetal and maternal tissues during early pregnancy and plays an important role during implantation, decidualization, and in fetal development. In the regulation of apoptosis, bcl-2 is one of the central controlling genes, and acts by protecting the cell against apoptosis. It is postulated that invasiveness of ectopic trophoblast towards and through the muscularis zone of the tubal wall consequently leading to tubal rupture might be due to disturbed regulation of apoptosis. By means of immunohistochemistry and a computerized image analysis, bcl-2 immunostaining was localized and quantified in 36 randomly selected paraffin-embedded ectopic trophoblast tissue specimens collected from women undergoing surgery for ruptured (n = 18) and non-ruptured (n = 18) tubal ectopic pregnancies. Immunostaining was found in the villi syncytiotrophoblast in all patients, while the percentage of positive bcl-2 immunostained area (%PA) (P = 0.0009) and staining intensity (P = 0.0042) were consistently greater in the group of ruptured ectopic pregnancies. Including the variables %PA and saturation into a logistic regression model for a probability threshold of 0.5 (<0.5 = non-ruptured ectopic pregnancy, >0.5 = ruptured ectopic pregnancy) to identify tubal rupture, a sensitivity and specificity of 94.4% were found. It is suggested that elevated bcl-2 immunostaining in the syncytiotrophoblast layer reflects unlimited cell survival of ectopic trophoblast and could lead to the establishment of a circulating marker for tubal rupture." @default.
• W2124209097 created "2016-06-24" @default.
• W2124209097 creator A5004390901 @default.
• W2124209097 creator A5009903252 @default.
• W2124209097 creator A5029591912 @default.
• W2124209097 creator A5030953625 @default.
• W2124209097 creator A5043337328 @default.
• W2124209097 creator A5064941330 @default.
• W2124209097 date "2001-06-01" @default.
• W2124209097 modified "2023-10-18" @default.
• W2124209097 title "Bcl-2 expression as a novel immunohistochemical marker for ruptured tubal ectopic pregnancy" @default.
• W2124209097 cites W1589415602 @default.
• W2124209097 cites W1802507215 @default.
• W2124209097 cites W1963546793 @default.
• W2124209097 cites W1966016767 @default.
• W2124209097 cites W1991545969 @default.
• W2124209097 cites W1993224545 @default.
• W2124209097 cites W2014482236 @default.
• W2124209097 cites W2028460109 @default.
• W2124209097 cites W2038353635 @default.
• W2124209097 cites W2055401539 @default.
• W2124209097 cites W2057257609 @default.
• W2124209097 cites W2070762401 @default.
• W2124209097 cites W2091804814 @default.
• W2124209097 cites W2104330540 @default.
• W2124209097 cites W2106246659 @default.
• W2124209097 cites W2109246060 @default.
• W2124209097 cites W2128313579 @default.
• W2124209097 cites W2150288891 @default.
• W2124209097 cites W2165552019 @default.
• W2124209097 cites W2167212332 @default.
• W2124209097 cites W2167775285 @default.
• W2124209097 cites W2308426564 @default.
• W2124209097 cites W2411635247 @default.
• W2124209097 cites W3043647 @default.
• W2124209097 cites W51232830 @default.
• W2124209097 doi "https://doi.org/10.1093/humrep/16.6.1286" @default.
• W2124209097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11387307" @default.
• W2124209097 hasPublicationYear "2001" @default.
• W2124209097 type Work @default.
• W2124209097 sameAs 2124209097 @default.
• W2124209097 citedByCount "9" @default.
• W2124209097 countsByYear W21242090972015 @default.
• W2124209097 countsByYear W21242090972016 @default.
• W2124209097 countsByYear W21242090972019 @default.
• W2124209097 crossrefType "journal-article" @default.
• W2124209097 hasAuthorship W2124209097A5004390901 @default.
• W2124209097 hasAuthorship W2124209097A5009903252 @default.
• W2124209097 hasAuthorship W2124209097A5029591912 @default.
• W2124209097 hasAuthorship W2124209097A5030953625 @default.
• W2124209097 hasAuthorship W2124209097A5043337328 @default.
• W2124209097 hasAuthorship W2124209097A5064941330 @default.
• W2124209097 hasBestOaLocation W21242090971 @default.
• W2124209097 hasConcept C142724271 @default.
• W2124209097 hasConcept C16685009 @default.
• W2124209097 hasConcept C172680121 @default.
• W2124209097 hasConcept C190283241 @default.
• W2124209097 hasConcept C204232928 @default.
• W2124209097 hasConcept C2776018949 @default.
• W2124209097 hasConcept C2776953305 @default.
• W2124209097 hasConcept C2777495146 @default.
• W2124209097 hasConcept C2779234561 @default.
• W2124209097 hasConcept C2779315647 @default.
• W2124209097 hasConcept C2780197806 @default.
• W2124209097 hasConcept C4224716 @default.
• W2124209097 hasConcept C54355233 @default.
• W2124209097 hasConcept C55493867 @default.
• W2124209097 hasConcept C71924100 @default.
• W2124209097 hasConcept C81885089 @default.
• W2124209097 hasConcept C86803240 @default.
• W2124209097 hasConcept C97037327 @default.
• W2124209097 hasConceptScore W2124209097C142724271 @default.
• W2124209097 hasConceptScore W2124209097C16685009 @default.
• W2124209097 hasConceptScore W2124209097C172680121 @default.
• W2124209097 hasConceptScore W2124209097C190283241 @default.
• W2124209097 hasConceptScore W2124209097C204232928 @default.
• W2124209097 hasConceptScore W2124209097C2776018949 @default.
• W2124209097 hasConceptScore W2124209097C2776953305 @default.
• W2124209097 hasConceptScore W2124209097C2777495146 @default.
• W2124209097 hasConceptScore W2124209097C2779234561 @default.
• W2124209097 hasConceptScore W2124209097C2779315647 @default.
• W2124209097 hasConceptScore W2124209097C2780197806 @default.
• W2124209097 hasConceptScore W2124209097C4224716 @default.
• W2124209097 hasConceptScore W2124209097C54355233 @default.
• W2124209097 hasConceptScore W2124209097C55493867 @default.
• W2124209097 hasConceptScore W2124209097C71924100 @default.
• W2124209097 hasConceptScore W2124209097C81885089 @default.
• W2124209097 hasConceptScore W2124209097C86803240 @default.
• W2124209097 hasConceptScore W2124209097C97037327 @default.
• W2124209097 hasIssue "6" @default.
• W2124209097 hasLocation W21242090971 @default.
• W2124209097 hasLocation W21242090972 @default.
• W2124209097 hasOpenAccess W2124209097 @default.
• W2124209097 hasPrimaryLocation W21242090971 @default.
• W2124209097 hasRelatedWork W2039546666 @default.
• W2124209097 hasRelatedWork W2051133605 @default.
• W2124209097 hasRelatedWork W2072206258 @default.
• W2124209097 hasRelatedWork W2085666695 @default.

• next