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- W2124210363 abstract "The advent of new techniques, such as interphase fluorescence in situ hybridization, and, more recently, global array-based gene expression profiling, has accelerated genomic research in myeloma. Distinct biologic subtypes, characterized by unique genetic abnormalities with differing clinical outcomes, have been identified. The identification of these primary genetic defects, and the deregulated oncogenes and pathways in myeloma, has allowed for the development of more targeted therapies. This has led to the discovery of an increased number of active agents in the treatment of myeloma. Genetics also have prognostic importance in myeloma. Recent studies have elucidated a genetic prognostic hierarchy, and have enabled improved definition of the prognostic significance of their interactions. The current challenges are to: improve the dissection of the genetic heterogeneity of the disease; better define progression events; improve the risk stratification of patients; more accurately select patients who will respond well to a particular treatment; and develop more rational combinations of treatment. Genomics will have an important role to play in all of these goals." @default.
- W2124210363 created "2016-06-24" @default.
- W2124210363 creator A5003015868 @default.
- W2124210363 creator A5066282840 @default.
- W2124210363 date "2005-09-01" @default.
- W2124210363 modified "2023-10-14" @default.
- W2124210363 title "Genomics in multiple myeloma: biology and clinical implications" @default.
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- W2124210363 cites W1538098067 @default.
- W2124210363 cites W1568606301 @default.
- W2124210363 cites W1600294598 @default.
- W2124210363 cites W1602983699 @default.
- W2124210363 cites W1608640012 @default.
- W2124210363 cites W1966229399 @default.
- W2124210363 cites W1968689574 @default.
- W2124210363 cites W1971199955 @default.
- W2124210363 cites W1977002391 @default.
- W2124210363 cites W1977707370 @default.
- W2124210363 cites W1980471295 @default.
- W2124210363 cites W1981102741 @default.
- W2124210363 cites W1984534203 @default.
- W2124210363 cites W1985707369 @default.
- W2124210363 cites W1988178556 @default.
- W2124210363 cites W1991509879 @default.
- W2124210363 cites W1991550920 @default.
- W2124210363 cites W1992138571 @default.
- W2124210363 cites W1993549070 @default.
- W2124210363 cites W1999539429 @default.
- W2124210363 cites W1999860933 @default.
- W2124210363 cites W2002927100 @default.
- W2124210363 cites W2003275764 @default.
- W2124210363 cites W2008250750 @default.
- W2124210363 cites W2012958204 @default.
- W2124210363 cites W2013187395 @default.
- W2124210363 cites W2025531396 @default.
- W2124210363 cites W2025829112 @default.
- W2124210363 cites W2026496528 @default.
- W2124210363 cites W2027359959 @default.
- W2124210363 cites W2029607056 @default.
- W2124210363 cites W2030500412 @default.
- W2124210363 cites W2034438569 @default.
- W2124210363 cites W2039215669 @default.
- W2124210363 cites W2051045940 @default.
- W2124210363 cites W2053445935 @default.
- W2124210363 cites W2053456304 @default.
- W2124210363 cites W2054290966 @default.
- W2124210363 cites W2055927459 @default.
- W2124210363 cites W2056013867 @default.
- W2124210363 cites W2058580930 @default.
- W2124210363 cites W2059494778 @default.
- W2124210363 cites W2063827408 @default.
- W2124210363 cites W2068026063 @default.
- W2124210363 cites W2073981334 @default.
- W2124210363 cites W2074775218 @default.
- W2124210363 cites W2075175917 @default.
- W2124210363 cites W2078503792 @default.
- W2124210363 cites W2080164596 @default.
- W2124210363 cites W2082606971 @default.
- W2124210363 cites W2084657347 @default.
- W2124210363 cites W2085190236 @default.
- W2124210363 cites W2086918627 @default.
- W2124210363 cites W2088123597 @default.
- W2124210363 cites W2102140136 @default.
- W2124210363 cites W2103101762 @default.
- W2124210363 cites W2103114868 @default.
- W2124210363 cites W2103209498 @default.
- W2124210363 cites W2104148554 @default.
- W2124210363 cites W2104550035 @default.
- W2124210363 cites W2104634390 @default.
- W2124210363 cites W2110486997 @default.
- W2124210363 cites W2110502951 @default.
- W2124210363 cites W2113444305 @default.
- W2124210363 cites W2126116268 @default.
- W2124210363 cites W2127096655 @default.
- W2124210363 cites W2131554133 @default.
- W2124210363 cites W2138218344 @default.
- W2124210363 cites W2139954597 @default.
- W2124210363 cites W2148047805 @default.
- W2124210363 cites W2149052195 @default.
- W2124210363 cites W2149386327 @default.
- W2124210363 cites W2162700652 @default.
- W2124210363 cites W2163341100 @default.
- W2124210363 cites W2164807675 @default.
- W2124210363 cites W2166508172 @default.
- W2124210363 cites W2170444924 @default.
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- W2124210363 cites W2609515889 @default.
- W2124210363 cites W4237841130 @default.
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- W2124210363 doi "https://doi.org/10.2217/14622416.6.6.563" @default.
- W2124210363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16142997" @default.
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