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- W2124211545 abstract "N-of-1 or single subject clinical trials consider an individual patient as the sole unit of observation in a study investigating the efficacy or side-effect profiles of different interventions. The ultimate goal of an n-of-1 trial is to determine the optimal or best intervention for an individual patient using objective data-driven criteria. Such trials can leverage study design and statistical techniques associated with standard population-based clinical trials, including randomization, washout and crossover periods, as well as placebo controls. Despite their obvious appeal and wide use in educational settings, n-of-1 trials have been used sparingly in medical and general clinical settings. We briefly review the history, motivation and design of n-of-1 trials and emphasize the great utility of modern wireless medical monitoring devices in their execution. We ultimately argue that n-of-1 trials demand serious attention among the health research and clinical care communities given the contemporary focus on individualized medicine." @default.
- W2124211545 created "2016-06-24" @default.
- W2124211545 creator A5011911976 @default.
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- W2124211545 creator A5077225971 @default.
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- W2124211545 date "2011-03-01" @default.
- W2124211545 modified "2023-10-18" @default.
- W2124211545 title "The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?" @default.
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- W2124211545 doi "https://doi.org/10.2217/pme.11.7" @default.
- W2124211545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118090" @default.
- W2124211545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21695041" @default.
- W2124211545 hasPublicationYear "2011" @default.
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