FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124219489> ?p ?o ?g. }

• W2124219489 endingPage "561" @default.
• W2124219489 startingPage "556" @default.
• W2124219489 abstract "Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely, 2-oxoglutarate, a precursor of hydroxyproline, the most abundant amino acid in bone collagen, counteracts the bone loss. The aim of the present study was to elucidate the influence of omeprazole on bone and investigate whether dietary 2-oxoglutarate supplementation could prevent the effects of omeprazole.Eighteen male Sprague-Dawley rats were used. Rats received omeprazole in the diet and 2-oxoglutarate in the drinking water. Body and organ weights and serum concentrations of cholecystokinin and gastrin were measured. The femurs, tibias, and calvarias were collected. Histomorphometric analysis of bone and cartilage tissues was conducted. Bone densitometric and peripheral quantitative computed tomographic analyses of the femur and tibia were performed.Omeprazole decreased the femur and tibia weights, the mechanical properties of the femur, the volumetric bone density and content, the trabecular and cortical bone mineral content, the total, trabecular, and cortical bone areas, the mean cortical thickness, and the periosteal circumference of the femur. Omeprazole had a minor effect on the examined bone morphology and exerted negligible effects on the cartilage. 2-Oxoglutarate lowered the gastrin concentration.Omeprazole treatment exerts its effects mostly on bone mineralization and cancellous bone, adversely affecting bone properties. This adverse effect of omeprazole was not markedly abolished by 2-oxoglutaric acid, which acted as an anti-hypergastrinemic agent." @default.
• W2124219489 created "2016-06-24" @default.
• W2124219489 creator A5002417503 @default.
• W2124219489 creator A5002560985 @default.
• W2124219489 creator A5005612180 @default.
• W2124219489 creator A5025723939 @default.
• W2124219489 creator A5064225609 @default.
• W2124219489 creator A5075893726 @default.
• W2124219489 creator A5083137721 @default.
• W2124219489 date "2013-03-01" @default.
• W2124219489 modified "2023-09-27" @default.
• W2124219489 title "Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?" @default.
• W2124219489 cites W1922703745 @default.
• W2124219489 cites W1976698733 @default.
• W2124219489 cites W1977163452 @default.
• W2124219489 cites W1982503478 @default.
• W2124219489 cites W1982728222 @default.
• W2124219489 cites W1985994440 @default.
• W2124219489 cites W1991413218 @default.
• W2124219489 cites W2026798270 @default.
• W2124219489 cites W2032199741 @default.
• W2124219489 cites W2038324340 @default.
• W2124219489 cites W2040645722 @default.
• W2124219489 cites W2048452039 @default.
• W2124219489 cites W2052901016 @default.
• W2124219489 cites W2060015321 @default.
• W2124219489 cites W2075833301 @default.
• W2124219489 cites W2082010609 @default.
• W2124219489 cites W2082485240 @default.
• W2124219489 cites W2085481222 @default.
• W2124219489 cites W2087750333 @default.
• W2124219489 cites W2089554013 @default.
• W2124219489 cites W2090127728 @default.
• W2124219489 cites W2102727685 @default.
• W2124219489 cites W2113351446 @default.
• W2124219489 cites W2115932877 @default.
• W2124219489 cites W2116460209 @default.
• W2124219489 cites W2120390531 @default.
• W2124219489 cites W2123564870 @default.
• W2124219489 cites W2137902301 @default.
• W2124219489 cites W2138735946 @default.
• W2124219489 cites W2139871454 @default.
• W2124219489 cites W2143121646 @default.
• W2124219489 cites W2148792541 @default.
• W2124219489 cites W2162110873 @default.
• W2124219489 cites W2167359851 @default.
• W2124219489 cites W2169843138 @default.
• W2124219489 cites W4253113439 @default.
• W2124219489 doi "https://doi.org/10.1016/j.nut.2012.07.014" @default.
• W2124219489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23218481" @default.
• W2124219489 hasPublicationYear "2013" @default.
• W2124219489 type Work @default.
• W2124219489 sameAs 2124219489 @default.
• W2124219489 citedByCount "20" @default.
• W2124219489 countsByYear W21242194892015 @default.
• W2124219489 countsByYear W21242194892016 @default.
• W2124219489 countsByYear W21242194892017 @default.
• W2124219489 countsByYear W21242194892019 @default.
• W2124219489 countsByYear W21242194892020 @default.
• W2124219489 countsByYear W21242194892021 @default.
• W2124219489 countsByYear W21242194892022 @default.
• W2124219489 crossrefType "journal-article" @default.
• W2124219489 hasAuthorship W2124219489A5002417503 @default.
• W2124219489 hasAuthorship W2124219489A5002560985 @default.
• W2124219489 hasAuthorship W2124219489A5005612180 @default.
• W2124219489 hasAuthorship W2124219489A5025723939 @default.
• W2124219489 hasAuthorship W2124219489A5064225609 @default.
• W2124219489 hasAuthorship W2124219489A5075893726 @default.
• W2124219489 hasAuthorship W2124219489A5083137721 @default.
• W2124219489 hasConcept C105702510 @default.
• W2124219489 hasConcept C126322002 @default.
• W2124219489 hasConcept C134018914 @default.
• W2124219489 hasConcept C141071460 @default.
• W2124219489 hasConcept C185592680 @default.
• W2124219489 hasConcept C2776541429 @default.
• W2124219489 hasConcept C2776886416 @default.
• W2124219489 hasConcept C2777236700 @default.
• W2124219489 hasConcept C2777498785 @default.
• W2124219489 hasConcept C2779797417 @default.
• W2124219489 hasConcept C2780550940 @default.
• W2124219489 hasConcept C2780554211 @default.
• W2124219489 hasConcept C2781025758 @default.
• W2124219489 hasConcept C2781451080 @default.
• W2124219489 hasConcept C673006 @default.
• W2124219489 hasConcept C71924100 @default.
• W2124219489 hasConceptScore W2124219489C105702510 @default.
• W2124219489 hasConceptScore W2124219489C126322002 @default.
• W2124219489 hasConceptScore W2124219489C134018914 @default.
• W2124219489 hasConceptScore W2124219489C141071460 @default.
• W2124219489 hasConceptScore W2124219489C185592680 @default.
• W2124219489 hasConceptScore W2124219489C2776541429 @default.
• W2124219489 hasConceptScore W2124219489C2776886416 @default.
• W2124219489 hasConceptScore W2124219489C2777236700 @default.
• W2124219489 hasConceptScore W2124219489C2777498785 @default.
• W2124219489 hasConceptScore W2124219489C2779797417 @default.
• W2124219489 hasConceptScore W2124219489C2780550940 @default.
• W2124219489 hasConceptScore W2124219489C2780554211 @default.
• W2124219489 hasConceptScore W2124219489C2781025758 @default.

• next