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• W2124223800 endingPage "46" @default.
• W2124223800 startingPage "33" @default.
• W2124223800 abstract "Abstract The decapping of eukaryotic mRNAs is a key step in their degradation. The heteroheptameric Lsm1p–7p complex is a general activator of decapping and also functions in protecting the 3′ ends of deadenylated mRNAs from a 3′-trimming reaction. Lsm1p is the unique member of the Lsm1p–7p complex, distinguishing that complex from the functionally different Lsm2p–8p complex. To understand the function of Lsm1p, we constructed a series of deletion and point mutations of the LSM1 gene and examined their effects on phenotype. These studies revealed the following: (i) Mutations affecting the predicted RNA-binding and inter-subunit interaction residues of Lsm1p led to impairment of mRNA decay, suggesting that the integrity of the Lsm1p–7p complex and the ability of the Lsm1p–7p complex to interact with mRNA are important for mRNA decay function; (ii) mutations affecting the predicted RNA contact residues did not affect the localization of the Lsm1p–7p complex to the P-bodies; (iii) mRNA 3′-end protection could be indicative of the binding of the Lsm1p–7p complex to the mRNA prior to activation of decapping, since all the mutants defective in mRNA 3′ end protection were also blocked in mRNA decay; and (iv) in addition to the Sm domain, the C-terminal domain of Lsm1p is also important for mRNA decay function." @default.
• W2124223800 created "2016-06-24" @default.
• W2124223800 creator A5014796446 @default.
• W2124223800 creator A5038498972 @default.
• W2124223800 creator A5061861167 @default.
• W2124223800 creator A5072928109 @default.
• W2124223800 date "2005-05-01" @default.
• W2124223800 modified "2023-10-17" @default.
• W2124223800 title "Mutations in the Saccharomyces cerevisiae LSM1 Gene That Affect mRNA Decapping and 3′ End Protection" @default.
• W2124223800 cites W1833943928 @default.
• W2124223800 cites W1845702142 @default.
• W2124223800 cites W1881929849 @default.
• W2124223800 cites W1884783152 @default.
• W2124223800 cites W1903251151 @default.
• W2124223800 cites W1905489680 @default.
• W2124223800 cites W1914793851 @default.
• W2124223800 cites W1966595354 @default.
• W2124223800 cites W1970626969 @default.
• W2124223800 cites W1975338705 @default.
• W2124223800 cites W1976147540 @default.
• W2124223800 cites W1976527580 @default.
• W2124223800 cites W1978809302 @default.
• W2124223800 cites W1988498926 @default.
• W2124223800 cites W1990214042 @default.
• W2124223800 cites W1992468478 @default.
• W2124223800 cites W1997279341 @default.
• W2124223800 cites W2005642753 @default.
• W2124223800 cites W2005767434 @default.
• W2124223800 cites W2007085897 @default.
• W2124223800 cites W2016548334 @default.
• W2124223800 cites W2031345354 @default.
• W2124223800 cites W2031980657 @default.
• W2124223800 cites W2035398832 @default.
• W2124223800 cites W2035792284 @default.
• W2124223800 cites W2041703851 @default.
• W2124223800 cites W2043746705 @default.
• W2124223800 cites W2046461486 @default.
• W2124223800 cites W2049830784 @default.
• W2124223800 cites W2050406900 @default.
• W2124223800 cites W2066666252 @default.
• W2124223800 cites W2067370432 @default.
• W2124223800 cites W2068778722 @default.
• W2124223800 cites W2071541710 @default.
• W2124223800 cites W2073688200 @default.
• W2124223800 cites W2075181140 @default.
• W2124223800 cites W2076510291 @default.
• W2124223800 cites W2082258084 @default.
• W2124223800 cites W2082514511 @default.
• W2124223800 cites W2082658854 @default.
• W2124223800 cites W2091698280 @default.
• W2124223800 cites W2095676095 @default.
• W2124223800 cites W2096688350 @default.
• W2124223800 cites W2102813335 @default.
• W2124223800 cites W2104496647 @default.
• W2124223800 cites W2106543077 @default.
• W2124223800 cites W2108708613 @default.
• W2124223800 cites W2110348677 @default.
• W2124223800 cites W2114689146 @default.
• W2124223800 cites W2114717251 @default.
• W2124223800 cites W2115102378 @default.
• W2124223800 cites W2117403504 @default.
• W2124223800 cites W2117764830 @default.
• W2124223800 cites W2118880717 @default.
• W2124223800 cites W2121770428 @default.
• W2124223800 cites W2124145714 @default.
• W2124223800 cites W2126783966 @default.
• W2124223800 cites W2127297551 @default.
• W2124223800 cites W2130349346 @default.
• W2124223800 cites W2130386199 @default.
• W2124223800 cites W2130942741 @default.
• W2124223800 cites W2132398035 @default.
• W2124223800 cites W2134530067 @default.
• W2124223800 cites W2134910640 @default.
• W2124223800 cites W2135804883 @default.
• W2124223800 cites W2136175548 @default.
• W2124223800 cites W2136615690 @default.
• W2124223800 cites W2138148973 @default.
• W2124223800 cites W2140006817 @default.
• W2124223800 cites W2140514445 @default.
• W2124223800 cites W2142571092 @default.
• W2124223800 cites W2143138678 @default.
• W2124223800 cites W2146393576 @default.
• W2124223800 cites W2149480059 @default.
• W2124223800 cites W2152656750 @default.
• W2124223800 cites W2152758802 @default.
• W2124223800 cites W2152831256 @default.
• W2124223800 cites W2155640540 @default.
• W2124223800 cites W2157177142 @default.
• W2124223800 cites W2161448011 @default.
• W2124223800 cites W2161714250 @default.
• W2124223800 cites W2169333620 @default.
• W2124223800 cites W2170186108 @default.
• W2124223800 cites W2307518763 @default.
• W2124223800 cites W2340157291 @default.
• W2124223800 cites W4251440314 @default.
• W2124223800 cites W4252934881 @default.
• W2124223800 doi "https://doi.org/10.1534/genetics.104.034322" @default.
• W2124223800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1449704" @default.

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