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- W2124231617 startingPage "6" @default.
- W2124231617 abstract "Autism spectrum disorders (ASDs) are increasing in incidence but have an incompletely understood etiology. Tools for uncovering clues to the cause of ASDs and means for diagnoses are valuable to the field. Mass Spectrometry (MS) has been a useful method for evaluating differences between individuals with ASDs versus matched controls. Different biological substances can be evaluated using MS, including urine, blood, saliva, and hair. This technique has been used to evaluate relatively unsupported hypotheses based on introduction of exogenous factors, such as opiate and heavy metal excretion theories of ASDs. MS has also been used to support disturbances in serotonin-related molecules, which have been more consistently observed in ASDs. Serotonergic system markers, markers for oxidative stress, cholesterol system disturbances, peptide hypo-phosphorylation and methylation have been measured using MS in ASDs, although further analyses with larger numbers of subjects are needed (as well as consideration of behavioral data). Refinements in MS and data analysis are ongoing, allowing for the possibility that future studies examining body fluids and specimens from ASD subjects could continue to yield novel insights. This review summarizes MS investigations that have been conducted to study ASD to date and provides insight into future promising applications for this technique, with focus on proteomic studies." @default.
- W2124231617 created "2016-06-24" @default.
- W2124231617 creator A5016000610 @default.
- W2124231617 creator A5017609986 @default.
- W2124231617 creator A5034942014 @default.
- W2124231617 creator A5036122174 @default.
- W2124231617 creator A5046022773 @default.
- W2124231617 creator A5053137671 @default.
- W2124231617 creator A5059055717 @default.
- W2124231617 creator A5061551511 @default.
- W2124231617 date "2013-01-01" @default.
- W2124231617 modified "2023-09-23" @default.
- W2124231617 title "Mass spectrometry as a tool for studying autism spectrum disorder" @default.
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