FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124234417> ?p ?o ?g. }

• W2124234417 endingPage "1139" @default.
• W2124234417 startingPage "1135" @default.
• W2124234417 abstract "Receptor tyrosine kinases (RTKs) regulate critical cell signaling pathways, yet the properties of their cognate ligands that influence receptor activation are not fully understood. There is great interest in parsing these complex ligand-receptor relationships using engineered proteins with altered binding properties. Here we focus on the interaction between two engineered epidermal growth factor (EGF) mutants and the EGF receptor (EGFR), a model member of the RTK superfamily. We found that EGF mutants with faster kinetic on-rates stimulate increased EGFR activation compared to wild-type EGF. These findings support previous predictions that faster association rates correlate with enhanced receptor activity." @default.
• W2124234417 created "2016-06-24" @default.
• W2124234417 creator A5002992439 @default.
• W2124234417 creator A5005728573 @default.
• W2124234417 creator A5029326728 @default.
• W2124234417 creator A5055875576 @default.
• W2124234417 creator A5058204963 @default.
• W2124234417 creator A5063404563 @default.
• W2124234417 creator A5075819969 @default.
• W2124234417 creator A5079088180 @default.
• W2124234417 date "2011-03-23" @default.
• W2124234417 modified "2023-10-03" @default.
• W2124234417 title "Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation" @default.
• W2124234417 cites W1511802745 @default.
• W2124234417 cites W1592646667 @default.
• W2124234417 cites W1988810593 @default.
• W2124234417 cites W2004677335 @default.
• W2124234417 cites W2028839182 @default.
• W2124234417 cites W2053669512 @default.
• W2124234417 cites W2059596821 @default.
• W2124234417 cites W2063917536 @default.
• W2124234417 cites W2075161553 @default.
• W2124234417 cites W2085155509 @default.
• W2124234417 cites W2094540897 @default.
• W2124234417 cites W2121134990 @default.
• W2124234417 cites W2125589729 @default.
• W2124234417 cites W2128678194 @default.
• W2124234417 cites W2138321569 @default.
• W2124234417 cites W2140864856 @default.
• W2124234417 cites W2153331113 @default.
• W2124234417 cites W2160925845 @default.
• W2124234417 cites W4244120980 @default.
• W2124234417 doi "https://doi.org/10.1016/j.febslet.2011.03.044" @default.
• W2124234417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118396" @default.
• W2124234417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21439278" @default.
• W2124234417 hasPublicationYear "2011" @default.
• W2124234417 type Work @default.
• W2124234417 sameAs 2124234417 @default.
• W2124234417 citedByCount "21" @default.
• W2124234417 countsByYear W21242344172012 @default.
• W2124234417 countsByYear W21242344172014 @default.
• W2124234417 countsByYear W21242344172015 @default.
• W2124234417 countsByYear W21242344172016 @default.
• W2124234417 countsByYear W21242344172017 @default.
• W2124234417 countsByYear W21242344172019 @default.
• W2124234417 countsByYear W21242344172020 @default.
• W2124234417 countsByYear W21242344172021 @default.
• W2124234417 crossrefType "journal-article" @default.
• W2124234417 hasAuthorship W2124234417A5002992439 @default.
• W2124234417 hasAuthorship W2124234417A5005728573 @default.
• W2124234417 hasAuthorship W2124234417A5029326728 @default.
• W2124234417 hasAuthorship W2124234417A5055875576 @default.
• W2124234417 hasAuthorship W2124234417A5058204963 @default.
• W2124234417 hasAuthorship W2124234417A5063404563 @default.
• W2124234417 hasAuthorship W2124234417A5075819969 @default.
• W2124234417 hasAuthorship W2124234417A5079088180 @default.
• W2124234417 hasBestOaLocation W21242344172 @default.
• W2124234417 hasConcept C101544691 @default.
• W2124234417 hasConcept C104317684 @default.
• W2124234417 hasConcept C143065580 @default.
• W2124234417 hasConcept C170493617 @default.
• W2124234417 hasConcept C185592680 @default.
• W2124234417 hasConcept C2776362946 @default.
• W2124234417 hasConcept C2779438470 @default.
• W2124234417 hasConcept C42362537 @default.
• W2124234417 hasConcept C55493867 @default.
• W2124234417 hasConcept C62478195 @default.
• W2124234417 hasConcept C86803240 @default.
• W2124234417 hasConcept C95444343 @default.
• W2124234417 hasConceptScore W2124234417C101544691 @default.
• W2124234417 hasConceptScore W2124234417C104317684 @default.
• W2124234417 hasConceptScore W2124234417C143065580 @default.
• W2124234417 hasConceptScore W2124234417C170493617 @default.
• W2124234417 hasConceptScore W2124234417C185592680 @default.
• W2124234417 hasConceptScore W2124234417C2776362946 @default.
• W2124234417 hasConceptScore W2124234417C2779438470 @default.
• W2124234417 hasConceptScore W2124234417C42362537 @default.
• W2124234417 hasConceptScore W2124234417C55493867 @default.
• W2124234417 hasConceptScore W2124234417C62478195 @default.
• W2124234417 hasConceptScore W2124234417C86803240 @default.
• W2124234417 hasConceptScore W2124234417C95444343 @default.
• W2124234417 hasIssue "8" @default.
• W2124234417 hasLocation W21242344171 @default.
• W2124234417 hasLocation W21242344172 @default.
• W2124234417 hasLocation W21242344173 @default.
• W2124234417 hasLocation W21242344174 @default.
• W2124234417 hasOpenAccess W2124234417 @default.
• W2124234417 hasPrimaryLocation W21242344171 @default.
• W2124234417 hasRelatedWork W153749366 @default.
• W2124234417 hasRelatedWork W1997172072 @default.
• W2124234417 hasRelatedWork W2009437679 @default.
• W2124234417 hasRelatedWork W2037040048 @default.
• W2124234417 hasRelatedWork W2134108931 @default.
• W2124234417 hasRelatedWork W2323546341 @default.
• W2124234417 hasRelatedWork W2348662540 @default.
• W2124234417 hasRelatedWork W2560520812 @default.
• W2124234417 hasRelatedWork W4230129753 @default.
• W2124234417 hasRelatedWork W1486376587 @default.

• next