FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124242016> ?p ?o ?g. }

• W2124242016 endingPage "3373" @default.
• W2124242016 startingPage "3368" @default.
• W2124242016 abstract "ABSTRACT An amoxicillin-resistant (Amox r ) strain of Helicobacter pylori was selected for by culturing an amoxicillin-sensitive (Amox s ) strain in increasingly higher concentrations of amoxicillin, resulting in a 133-fold increase in MIC, from 0.03 to 0.06 μg/ml to 4 to 8 μg/ml. This resistance was stable upon freezing for at least 6 months and conferred cross-resistance to seven other β-lactam antibiotics. β-Lactamase activity was not detected in this Amox r strain; however, analysis of the penicillin-binding protein (PBP) profiles generated from isolated bacterial membranes of the Amox s parental strain and the Amox r strain revealed a significant decrease in labeling of PBP 1 by biotinylated amoxicillin (bio-Amox) in the Amox r strain. Comparative binding studies of PBP 1 for several β-lactams demonstrated that PBP 1 in the Amox r strain had decreased affinity for mezlocillin but not significantly decreased affinity for penicillin G. In addition, PBP profiles prepared from whole bacterial cells showed decreased labeling of PBP 1 and PBP 2 in the Amox r strain at all bio-Amox concentrations tested, suggesting a diffusional barrier to bio-Amox or a possible antibiotic efflux mechanism. Uptake analysis of 14 C-labeled penicillin G showed a significant decrease in uptake of the labeled antibiotic by the Amox r strain compared to the Amox s strain, which was not affected by pretreatment with carbonyl cyanide m -chlorophenylhydrazone, eliminating the possibility of an efflux mechanism in the resistant strain. These results demonstrate that alterations in PBP 1 and in the uptake of β-lactam antibiotics in H. pylori can be selected for by prolonged exposure to amoxicillin, resulting in increased resistance to this antibiotic." @default.
• W2124242016 created "2016-06-24" @default.
• W2124242016 creator A5037052017 @default.
• W2124242016 creator A5091129386 @default.
• W2124242016 date "2000-12-01" @default.
• W2124242016 modified "2023-10-16" @default.
• W2124242016 title "Characterization of an In Vitro-Selected Amoxicillin-Resistant Strain of <i>Helicobacter pylori</i>" @default.
• W2124242016 cites W1544001516 @default.
• W2124242016 cites W1573080626 @default.
• W2124242016 cites W1912943847 @default.
• W2124242016 cites W1986091227 @default.
• W2124242016 cites W2016299826 @default.
• W2124242016 cites W2022600741 @default.
• W2124242016 cites W2024692727 @default.
• W2124242016 cites W2036229454 @default.
• W2124242016 cites W2050040839 @default.
• W2124242016 cites W2055182865 @default.
• W2124242016 cites W2059956455 @default.
• W2124242016 cites W2064958532 @default.
• W2124242016 cites W2072409841 @default.
• W2124242016 cites W2075005087 @default.
• W2124242016 cites W2082329713 @default.
• W2124242016 cites W2106298592 @default.
• W2124242016 cites W2107399540 @default.
• W2124242016 cites W2110132014 @default.
• W2124242016 cites W2111832211 @default.
• W2124242016 cites W2113957516 @default.
• W2124242016 cites W2114364509 @default.
• W2124242016 cites W2121867408 @default.
• W2124242016 cites W2123370383 @default.
• W2124242016 cites W2132830149 @default.
• W2124242016 cites W2135349234 @default.
• W2124242016 cites W2138014596 @default.
• W2124242016 cites W2140124461 @default.
• W2124242016 cites W2142263680 @default.
• W2124242016 cites W2145287701 @default.
• W2124242016 cites W2147985631 @default.
• W2124242016 cites W2152000612 @default.
• W2124242016 cites W2153323022 @default.
• W2124242016 cites W2157681443 @default.
• W2124242016 cites W2165505839 @default.
• W2124242016 cites W2166670508 @default.
• W2124242016 cites W2335653734 @default.
• W2124242016 cites W2355265432 @default.
• W2124242016 cites W4211017205 @default.
• W2124242016 doi "https://doi.org/10.1128/aac.44.12.3368-3373.2000" @default.
• W2124242016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/90207" @default.
• W2124242016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11083642" @default.
• W2124242016 hasPublicationYear "2000" @default.
• W2124242016 type Work @default.
• W2124242016 sameAs 2124242016 @default.
• W2124242016 citedByCount "71" @default.
• W2124242016 countsByYear W21242420162012 @default.
• W2124242016 countsByYear W21242420162013 @default.
• W2124242016 countsByYear W21242420162014 @default.
• W2124242016 countsByYear W21242420162015 @default.
• W2124242016 countsByYear W21242420162016 @default.
• W2124242016 countsByYear W21242420162017 @default.
• W2124242016 countsByYear W21242420162018 @default.
• W2124242016 countsByYear W21242420162021 @default.
• W2124242016 crossrefType "journal-article" @default.
• W2124242016 hasAuthorship W2124242016A5037052017 @default.
• W2124242016 hasAuthorship W2124242016A5091129386 @default.
• W2124242016 hasBestOaLocation W21242420161 @default.
• W2124242016 hasConcept C105702510 @default.
• W2124242016 hasConcept C174802600 @default.
• W2124242016 hasConcept C200082930 @default.
• W2124242016 hasConcept C2776653525 @default.
• W2124242016 hasConcept C2778022156 @default.
• W2124242016 hasConcept C2779708577 @default.
• W2124242016 hasConcept C3019249092 @default.
• W2124242016 hasConcept C501593827 @default.
• W2124242016 hasConcept C55493867 @default.
• W2124242016 hasConcept C86803240 @default.
• W2124242016 hasConcept C89423630 @default.
• W2124242016 hasConceptScore W2124242016C105702510 @default.
• W2124242016 hasConceptScore W2124242016C174802600 @default.
• W2124242016 hasConceptScore W2124242016C200082930 @default.
• W2124242016 hasConceptScore W2124242016C2776653525 @default.
• W2124242016 hasConceptScore W2124242016C2778022156 @default.
• W2124242016 hasConceptScore W2124242016C2779708577 @default.
• W2124242016 hasConceptScore W2124242016C3019249092 @default.
• W2124242016 hasConceptScore W2124242016C501593827 @default.
• W2124242016 hasConceptScore W2124242016C55493867 @default.
• W2124242016 hasConceptScore W2124242016C86803240 @default.
• W2124242016 hasConceptScore W2124242016C89423630 @default.
• W2124242016 hasIssue "12" @default.
• W2124242016 hasLocation W21242420161 @default.
• W2124242016 hasLocation W21242420162 @default.
• W2124242016 hasLocation W21242420163 @default.
• W2124242016 hasOpenAccess W2124242016 @default.
• W2124242016 hasPrimaryLocation W21242420161 @default.
• W2124242016 hasRelatedWork W1932616695 @default.
• W2124242016 hasRelatedWork W1958176239 @default.
• W2124242016 hasRelatedWork W2068407850 @default.
• W2124242016 hasRelatedWork W2071988704 @default.
• W2124242016 hasRelatedWork W2104240326 @default.
• W2124242016 hasRelatedWork W2113491104 @default.

• next