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• W2124244167 abstract "ObjectiveTo evaluate patient, stimulation and embryology parameters that could be used to predict multiple and high-order multiple gestations following in vitro fertilization − embryo transfer (IVF-ET).DesignRetrospective analysis.Materials and methodsWe included all IVF/ ICSI cycles where pregnancy outcome was known from years 2002–2003. Patient (age, baseline follicle stimulating hormone[FSH], etiology of infertility), stimulation (protocol, number of follicles, oocytes, mature oocytes, fertilization rate, endometrial thickness) and embryology (number of embryos transferred, quality of best embryo transferred, embryo score[ESC]) parameters were collected. Pathologic pregnancies (miscarriage, ectopic pregnancy) were excluded form the final analysis. T-test, Mann-Whitney-U test and logistic regression analysis were used.ResultsPregnancy outcome was known for 3528 fresh IVF/ICSI cycles. 898 cycles resulted in viable pregnancy (25.4%; 641 singleton, 199 twins, 54 triplet, 4 quadruplet). The number of oocytes retrieved (p=0.006), number of mature MII oocytes (p=0.001), number of fertilized oocytes (p=0.001), number of embryos transferred (p<0.0001) and the mean ESC (0.001) were significantly associated with multiple gestations. In addition, in cycles where surplus embryos were available for cryopreservation the risk of multiple gestations was higher. Using logistic regression analysis ESC (OR: 1.008[95%CI: 1.000–1.015] p=0.044), and the number of embryos transferred (OR: 1.292[95%CI: 0.99–1.686] p=0.06), were positively, while baseline FSH (OR: 0.934[95% CI: 0.971–0.994) p=0.032) was negatively associated with multiple gestations. The same parameters were significantly associated with high-order multiple gestations as well. High-order multiple gestations were more frequent among younger (< 35 years) women (p=0.053)ConclusionMultiple gestations especially high-order multiple gestations are undesired outcome of ART. Young patients and those with several high quality embryos should not have more than 2 embryos transferred to reduce the incidence of multiple gestations. ObjectiveTo evaluate patient, stimulation and embryology parameters that could be used to predict multiple and high-order multiple gestations following in vitro fertilization − embryo transfer (IVF-ET). To evaluate patient, stimulation and embryology parameters that could be used to predict multiple and high-order multiple gestations following in vitro fertilization − embryo transfer (IVF-ET). DesignRetrospective analysis. Retrospective analysis. Materials and methodsWe included all IVF/ ICSI cycles where pregnancy outcome was known from years 2002–2003. Patient (age, baseline follicle stimulating hormone[FSH], etiology of infertility), stimulation (protocol, number of follicles, oocytes, mature oocytes, fertilization rate, endometrial thickness) and embryology (number of embryos transferred, quality of best embryo transferred, embryo score[ESC]) parameters were collected. Pathologic pregnancies (miscarriage, ectopic pregnancy) were excluded form the final analysis. T-test, Mann-Whitney-U test and logistic regression analysis were used. We included all IVF/ ICSI cycles where pregnancy outcome was known from years 2002–2003. Patient (age, baseline follicle stimulating hormone[FSH], etiology of infertility), stimulation (protocol, number of follicles, oocytes, mature oocytes, fertilization rate, endometrial thickness) and embryology (number of embryos transferred, quality of best embryo transferred, embryo score[ESC]) parameters were collected. Pathologic pregnancies (miscarriage, ectopic pregnancy) were excluded form the final analysis. T-test, Mann-Whitney-U test and logistic regression analysis were used. ResultsPregnancy outcome was known for 3528 fresh IVF/ICSI cycles. 898 cycles resulted in viable pregnancy (25.4%; 641 singleton, 199 twins, 54 triplet, 4 quadruplet). The number of oocytes retrieved (p=0.006), number of mature MII oocytes (p=0.001), number of fertilized oocytes (p=0.001), number of embryos transferred (p<0.0001) and the mean ESC (0.001) were significantly associated with multiple gestations. In addition, in cycles where surplus embryos were available for cryopreservation the risk of multiple gestations was higher. Using logistic regression analysis ESC (OR: 1.008[95%CI: 1.000–1.015] p=0.044), and the number of embryos transferred (OR: 1.292[95%CI: 0.99–1.686] p=0.06), were positively, while baseline FSH (OR: 0.934[95% CI: 0.971–0.994) p=0.032) was negatively associated with multiple gestations. The same parameters were significantly associated with high-order multiple gestations as well. High-order multiple gestations were more frequent among younger (< 35 years) women (p=0.053) Pregnancy outcome was known for 3528 fresh IVF/ICSI cycles. 898 cycles resulted in viable pregnancy (25.4%; 641 singleton, 199 twins, 54 triplet, 4 quadruplet). The number of oocytes retrieved (p=0.006), number of mature MII oocytes (p=0.001), number of fertilized oocytes (p=0.001), number of embryos transferred (p<0.0001) and the mean ESC (0.001) were significantly associated with multiple gestations. In addition, in cycles where surplus embryos were available for cryopreservation the risk of multiple gestations was higher. Using logistic regression analysis ESC (OR: 1.008[95%CI: 1.000–1.015] p=0.044), and the number of embryos transferred (OR: 1.292[95%CI: 0.99–1.686] p=0.06), were positively, while baseline FSH (OR: 0.934[95% CI: 0.971–0.994) p=0.032) was negatively associated with multiple gestations. The same parameters were significantly associated with high-order multiple gestations as well. High-order multiple gestations were more frequent among younger (< 35 years) women (p=0.053) ConclusionMultiple gestations especially high-order multiple gestations are undesired outcome of ART. Young patients and those with several high quality embryos should not have more than 2 embryos transferred to reduce the incidence of multiple gestations. Multiple gestations especially high-order multiple gestations are undesired outcome of ART. Young patients and those with several high quality embryos should not have more than 2 embryos transferred to reduce the incidence of multiple gestations." @default.
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• W2124244167 date "2004-09-01" @default.
• W2124244167 modified "2023-10-18" @default.
• W2124244167 title "Predictors of multiple and high-order multiple gestations following IVF-ICSI/ ET cycles" @default.
• W2124244167 doi "https://doi.org/10.1016/j.fertnstert.2004.07.555" @default.
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